JACKSON HEART STUDY (JHS) GRADUATE TRAINING AND EDUCATION CENTER (GTEC) - TASK AREA B

杰克逊心脏研究 (JHS) 研究生培训和教育中心 (GTEC) - 任务区 B

• 批准号: 10972975
• 负责人: MARINELLE PAYTON
• 金额: $ 220万
• 依托单位: JACKSON STATE UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2023
• 资助国家: 美国
• 起止时间: 2023-08-13 至 2025-08-12
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10972975
• 关键词: JACKSON; HEART; STUDY; JHS; GRADUATE

The Jackson Heart Study (JHS) (https://www.jacksonheartstudy.org/) initiated in 1998 is a longitudinal investigation of genetic and environmental risk factors associated with the disproportionate burden of cardiovascular disease in African Americans. In addition, the JHS conducts community education and outreach activities to promote healthy lifestyles and reduce disease risk burden, undergraduate and graduate level research training programs, and high school science and math enrichment programs to prepare and encourage underrepresented minority students to pursue biomedical careers. The JHS is funded by the National Heart, Lung and Blood Institute (NHLBI) and the National Institute on Minority Health and Health Disparities (NIMHD). The JHS represents an expansion of the Jackson Field Center of the Atherosclerosis Risk in Communities (ARIC) study (http://www2.cscc.unc.edu/aric/) to broaden data collection in an African American population and to increase access to and participation of African American populations and scientists in biomedical research and professions. The JHS recruited 5306 African American residents living in the Jackson, Mississippi, metropolitan area of Hinds, Madison, and Rankin Counties. Participants were enrolled from 4 recruitment pools: random, 17%; volunteer, 30%; currently enrolled in the ARIC Study, 31% and secondary family members, 22%. Recruitment was limited to non-institutionalized adult African American men and women, 35-84 years old, except in a nested family cohort where those 21 to 34 years of age were also eligible. The final cohort of participants enrolled during the baseline exam included 6.6% of all African American men and women residents of the Jackson Mississippi Metropolitan Statistical Area aged 35-84 (N=76,426, US Census 2000). Among these participants, approximately 3400 gave consent that allows genetic research. JHS participants received three back-to-back clinical examinations (Exam 1, 2000-2004; Exam 2, 2005-2008; and Exam 3, 2009-2013) that have generated extensive longitudinal data on traditional and putative cardiovascular disease risk factors and measures of subclinical cardiovascular disease from echocardiography, cardiac magnetic resonance imaging and computed tomography scans. Biological samples (i.e., blood and urine) have been assayed for putative biochemical risk factors and stored for future research. DNA has been extracted and lymphocytes have been cryopreserved for studies of candidate genes, genome-wide scanning, expression, and other –omics investigations. In addition, JHS participants are contacted annually by telephone to update personal and health information including vital status, interim medical events, hospitalizations, functional status and sociocultural information. Ongoing cohort surveillance for cardiovascular events (i.e., coronary heart disease and related procedures, heart failure, and stroke) and deaths also involves data linkage with hospital discharge lists of JHS catchment area hospitals and the National Death Index (NDI). Medical records of cardiovascular disease related hospitalizations and death certificates are abstracted and used for adjudication of cardiovascular events and related deaths. The current JHS contracts (2018-2024) will include a clinical examination (Exam 4, 2/2020-11/2022) and investigation of the link between cardiovascular health and brain health.

杰克逊心脏研究（JHS）（https：//www.jacksonheartstudy.org/）于1998年启动，是一项与非裔美国人心血管疾病负担不成比例相关的遗传和环境风险因素的纵向研究。此外，JHS进行社区教育和推广活动，以促进健康的生活方式，减少疾病风险负担，本科和研究生水平的研究培训计划，以及高中科学和数学充实计划，以准备和鼓励代表性不足的少数民族学生追求生物医学事业。JHS由国家心脏，肺和血液研究所（NHLBI）和国家少数民族健康和健康差异研究所（NIMHD）资助。JHS是社区动脉粥样硬化风险研究（ARIC）杰克逊现场中心的扩展（http：//www2.cscc.unc.edu/aric/），旨在扩大非裔美国人群体的数据收集，并增加非裔美国人群体和科学家接触和参与生物医学研究和专业的机会。JHS招募了5306名居住在杰克逊、密西西比、Hinds、麦迪逊和兰金县的非裔美国居民。参与者从4个招募池中招募：随机，17%;志愿者，30%;目前参加ARIC研究，31%和二级家庭成员，22%。招募仅限于35-84岁的非制度化成年非洲裔美国男性和女性，除了嵌套家庭队列中的21 - 34岁也有资格。基线检查期间登记的最后一批参与者包括杰克逊密西西比大都会统计区年龄在35-84岁的所有非洲裔美国男性和女性居民的6.6%（N= 76，426，美国人口普查2000）。在这些参与者中，大约有3400人同意允许进行基因研究。JHS参与者接受了三次连续的临床检查（检查1，2000-2004;检查2，2005-2008;和检查3，2009-2013），这些检查产生了关于传统和推定心血管疾病风险因素的广泛纵向数据，以及超声心动图，心脏磁共振成像和计算机断层扫描的亚临床心血管疾病指标。生物样品（即，血液和尿液）进行了生化危险因子的测定，并储存起来用于将来的研究。提取DNA并冷冻保存淋巴细胞，用于候选基因的研究、全基因组扫描、表达和其他组学研究。此外，每年通过电话联系JHS参与者，以更新个人和健康信息，包括生命状况、临时医疗事件、住院情况、功能状况和社会文化信息。正在进行的心血管事件队列监测（即，冠状动脉心脏病和相关程序，心力衰竭和中风）和死亡还涉及与JHS集水区医院的出院名单和国家死亡指数（NDI）的数据链接。提取心血管疾病相关住院和死亡证明的病历，并用于裁定心血管事件和相关死亡。目前的JHS合同（2018-2024）将包括临床检查（考试4，2/2020-11/2022）和心血管健康与大脑健康之间联系的调查。