BIOINFORMATICS SUPPORT FOR DNTP & DIR

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The Bioinformatics support contract provides bioinformatics support for Omics technologies. Examples of projects needing support for bioinformatic analysis include toxicogenomic analysis for 1) support for circulating cell free DNA (ccfDNA); 2) support for Mouse Aging study by providing dendogram and SNP analysis for 10 strains of mice; 3) support epigenomic analysis of DNA methylation changes in an in vitro model of cellular transformation; 4) analysis of 3D spheroids of HepaRG. Differential gene expression from TempO-Seq data performed with fold changes and pvalues; 5) support provided for analysis of microarray toxicogenomic data for placenta and liver; 6) support for analysis of AFFF (aqueous film-forming foams) for comparative analysis of toxicity after in vitro exposures in HTT assays.