BIOINFORMATICS SUPPORT FOR DNTP & DIR

DNTP 的生物信息学支持

• 批准号: 10972790
• 负责人: RUCHIR SHAH
• 金额: $ 71.11万
• 依托单位: SCIOME, LLC
• 依托单位国家: 美国
• 财政年份: 2022
• 资助国家: 美国
• 起止时间: 2022-09-24 至 2023-12-23
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10972790
• 关键词: BIOINFORMATICS; SUPPORT; DNTP; DIR

The Bioinformatics support contract provides bioinformatics support for Omics technologies. Examples of projects needing support for bioinformatic analysis include toxicogenomic analysis for 1) support for circulating cell free DNA (ccfDNA); 2) support for Mouse Aging study by providing dendogram and SNP analysis for 10 strains of mice; 3) support epigenomic analysis of DNA methylation changes in an in vitro model of cellular transformation; 4) analysis of 3D spheroids of HepaRG. Differential gene expression from TempO-Seq data performed with fold changes and pvalues; 5) support provided for analysis of microarray toxicogenomic data for placenta and liver; 6) support for analysis of AFFF (aqueous film-forming foams) for comparative analysis of toxicity after in vitro exposures in HTT assays.

生物信息学支持合同为组学技术提供生物信息学支持。需要支持生物信息学分析的项目的例子包括毒理基因组学分析，1）支持循环无细胞DNA（ccfDNA）; 2）通过提供10种小鼠的树状图和SNP分析支持小鼠衰老研究; 3）支持体外细胞转化模型中DNA甲基化变化的表观基因组分析; 4）分析HepaRG的3D球状体。 使用倍数变化和p值进行的来自TempO-Seq数据的差异基因表达; 5）为胎盘和肝脏的微阵列毒理基因组学数据的分析提供支持; 6）为AFFF（水性成膜泡沫）的分析提供支持，用于HTT测定中体外暴露后毒性的比较分析。