HISPANIC COMMUNITY HEALTH STUDY-STUDY OF LATINOS (HCHS-SOL)

西班牙裔社区健康研究 - 拉丁裔研究 (HCHS-SOL)

• 批准号: 10972939
• 负责人: Robert C Kaplan
• 金额: $ 100万
• 依托单位: ALBERT EINSTEIN COLLEGE OF MEDICINE
• 依托单位国家: 美国
• 财政年份: 2018
• 资助国家: 美国
• 起止时间: 2018-11-30 至 2023-11-29
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10972939
• 关键词: HISPANIC; COMMUNITY; HEALTH; STUDY; LATINOS

The Hispanic Community Health Study-Study of Latinos (HCHS/SOL), an observational and longitudinal study of Hispanic/Latino heath was initiated in 2006. The study primary aims are (a) to describe the prevalence of selected diseases and conditions (especially cardiovascular and pulmonary diseases), (b) to describe the prevalence of risk or protective factors associated to those selected diseases, and (c) to study the relationship between baseline health profile and all-cause mortality and fatal and non-fatal cardiovascular and pulmonary events in a cohort of Hispanic/Latino adults of diverse heritage groups. From 2008 to 2011 over 16,000 Hispanic/Latino adults (aged 18-74 years) were recruited and examined in four U.S. cities (San Diego, CA; Chicago, IL; Miami, FL; and the Bronx, NY) following a probabilistic sampling of the participating communities. At baseline, the cohort included Hispanics/Latinos who self-identified their origin or heritage as Mexican (41%), Puerto Rican (17%), Cuban (15%), Dominican (9%), Central American (11%), and South American (7%). The aims of the baseline examination (Visit 1) were to estimate the prevalence of major cardiovascular and pulmonary diseases (CVPD) and their risk (or protective) factors, and the prevalence of other chronic conditions including hypertension, diabetes, obesity, hearing impairment, neurocognitive disorders, dental and periodontal disease, and sleep disorders, among others. In addition, a battery of interviews was administered by trained and certified personnel. Since 2009, the cohort has been prospectively followed to assess changes in health status (new diagnoses and CVPD risk factors), and visits to the emergency room, hospitalizations and deaths due to CVPD events (i.e., acute myocardial infarction, heart failure, stroke, and exacerbation of asthma and COPD) and all-cause mortality. Baseline cross-sectional analyses have been presented in many scientific meetings and published in scientific journals. A second examination (Visit 2) was initiated in October 2014 and completed in December 2017. The second examination (shorter than Visit 1) included an update in medical history (including CV risk factors and utilization of healthcare services), an echocardiogram for participants aged 45 years and older, and in-depth reproductive and pregnancy history from all women. Approximately 82% of participants participated in Visit 2 and throughout the annual follow-up interviews. Analyses involving changes in risk/protective factors over time (i.e., from Visit 1 to Visit 2) are currently being generated. The renewal of the funding to continue the annual follow-up, CVPD endpoint ascertainment (and potentially a third examination) is in progress. The performance of a third examination (Visit 3) is contingent upon the successful funding of an ancillary study that requires bringing participants (or a subsample) back to all Field Centers. The new contract is projected to start on December 1, 2018 and end on November 30, 2024.

拉丁美洲裔（HCHS/SOL）的西班牙裔社区健康研究是对西班牙裔/拉丁裔健康的观察和纵向研究。研究的主要目的是（a）描述所选疾病和状况的普遍性（尤其是心血管疾病和肺部疾病）的普遍性（尤其是针对这些疾病的风险），（B）（B）（B）（B）（B）（B）（B）（B）（B）（B）（B）（B）（B）（B）（B）（B）（B）（b）（b）（B）（B）（b）（B）（B）（B）（B）（b）（b）（B）（B）（b）（B）综合的因素（C）基线健康状况与全因死亡率以及致命的和非致命的心血管和肺部事件之间的关系，其中包括各种传统群体的西班牙裔/拉丁裔成年人。 从2008年到2011年，在美国四个城市（加利福尼亚州圣地亚哥；芝加哥，伊利诺伊州芝加哥；迈阿密，佛罗里达州和纽约州的纽约州）招募并检查了16,000多名西班牙裔/拉丁裔成年人（18-74岁），并在参与社区进行了概率抽样后进行了检查。在基准时，该队列包括西班牙裔/拉丁美洲人，他们自称是墨西哥人（41％），波多黎各人（17％），古巴人（15％），多米尼加（9％），中美洲（11％）和南美（7％）。基线检查的目的（访问1）是为了估计主要心血管和肺部疾病（CVPD）及其风险（或保护性）因素的患病率，以及其他慢性病的患病率，包括高血压，糖尿病，肥胖症，肥胖，助听器障碍，神经认知疾病，牙科疾病，牙科疾病，牙科和周期性疾病以及其他疾病，以及其他疾病，以及其他疾病。此外，由训练有素和经过认证的人员进行了一系列访谈。自2009年以来，该队列已被前瞻性地遵循，以评估健康状况的变化（新的诊断和CVPD风险因素），并访问急诊室，由于CVPD事件而导致的住院和死亡（即急性心肌梗塞，心脏失败，心力衰竭，中风，哮喘和COPD的恶化）和所有因素和所有因素和所有因素。基线横断面分析已在许多科学会议上进行了介绍，并在科学期刊上发表。 第二次检查（访问2）于2014年10月开始，并于2017年12月完成。第二次检查（较短的访问1）包括病史的更新（包括简历危险因素和医疗服务的利用），对45岁及45岁以上的参与者的超声心动图，以及所有女性的培养和怀孕历史。大约82％的参与者参加了访问2和整个年度后续访谈。随着时间的流逝，涉及风险/保护因素变化的分析（即，从访问1到访问2）正在生成。 续签了继续年度随访的资金，CVPD端点确定（可能是第三次检查）正在进行中。第三次检查的表现（访问3）取决于一项辅助研究的成功资金，该研究要求将参与者（或子样本）带回所有现场中心。新合同预计将于12月1日开始 2018年和2024年11月30日结束。