PASOS: Peripheral Artery Disease Study of SOL. An ancillary study of the Hispanic Community Health Study/Study of Latinos

PASOS：SOL 的外周动脉疾病研究。

• 批准号: 10447624
• 负责人: Robert C Kaplan
• 金额: $ 190.57万
• 依托单位: ALBERT EINSTEIN COLLEGE OF MEDICINE
• 依托单位国家: 美国
• 财政年份: 2019
• 资助国家: 美国
• 起止时间: 2019-08-01 至 2024-07-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10447624
• 关键词: Accelerometer; Address; Adult; Adverse effects; Affect; Amputation; Ancillary Study; Ankle; Arteries; Blood Vessels; Cardiovascular system; Classification; Clinic; Clinical; Clinical assessments; Cohort Studies; Communities; Data; Detection; Diabetes Mellitus; Diagnosis; Diagnostic tests; Disease; Disease Management; Eligibility Determination; Environment; Etiology; Event; Exercise; Exercise Therapy; Fatigue; General Population; Goals; Gold; Health; High Prevalence; Hispanic Community Health Study/Study of Latinos; Hispanic Populations; Hospitalization; Independent Living; Individual; Intermittent Claudication; Ischemia; Leg; Link; Longitudinal cohort study; Lower Extremity; Maintenance; Measurement; Measures; Medial; Medicare; Monitor; Outcome; Pain-Free; Participant; Patient Self-Report; Patients; Pattern; Peripheral arterial disease; Persons; Physical Function; Physical activity; Population; Population Study; Prediabetes syndrome; Process; Quality of life; Questionnaires; Reporting; Rest; Risk; Risk Factors; Study of Latinos; Supervision; Symptoms; Testing; Time; Toes; United States National Institutes of Health; Visit; Walking; Wrist; aged; artery stenosis; base; calcification; clinical application; clinical risk; cohort; diabetic; diagnostic strategy; disease diagnosis; high risk; hispanic community; indexing; insight; interest; meetings; mobile computing; mortality risk; prognostic value; prospective; research clinical testing; risk stratification; sedentary; sedentary lifestyle; ultrasound; wearable device

Lower extremity peripheral artery disease (PAD) affects 10 million adults in the US and increases the risk of mortality and leg amputation. Since it has broad implications for quality of life and maintenance of independent living, the impact of PAD on physical activity and function is of great interest. To characterize the impact of PAD on free-living daily physical activity and examine the value of objective assessment of daily physical activity for PAD management, diagnosis and risk stratification, we propose to evaluate enrollees of the Hispanic Community Cohort Study/Study of Latinos (HCHS/SOL). Participants who were originally studied during 2008-2011 will complete a return in person visit during 2019-2021. Through comprehensive clinical assessment of lower extremity blood vessels, multi-day accelerometry and physical function testing, we address the hypothesis that PAD will be identifiable by suboptimal usual activity patterns including longer sedentary time, higher activity fragmentation and diurnal patterns of activity. The study will also determine the prognostic value of 7-day physical activity, above and beyond self-reported leg symptoms and clinic-based physical function, to predict PAD-associated major health outcomes. Finally, duplex ultrasound of leg arteries in combination with other study assessments will be used to better resolve the population with indeterminant results on peripheral arterial disease clinical test. Results will help to guide the application of both clinical screening protocols and mobile technologies to identify, predict and intervene upon major health sequalae associated with PAD.

下肢外围动脉疾病（PAD）在美国影响1000万成年人， 增加死亡率和腿部截肢的风险。由于它对质量具有广泛的影响 独立生活的生活和维护，PAD对体育锻炼和功能的影响 非常有兴趣。表征垫子对自由生活日常体育锻炼的影响和 检查每日体育活动的客观评估用于垫垫管理的价值， 诊断和风险分层，我们建议评估西班牙裔社区的参与者 拉丁美洲人的队列研究/研究（HCHS/SOL）。最初研究的参与者 2008-2011将在2019 - 2021年期间亲自访问。通过全面 下肢血管，多天加速度计和物理的临床评估 功能测试，我们解决了以下假设，即通过次优的常规可以识别PAD 活动模式，包括更长的久坐时间，较高的活动碎片和昼夜 活动模式。该研究还将确定7天体育活动的预后价值， 超越自我报告的腿症状和基于诊所的身体机能，以预测 垫相关的主要健康结果。最后，腿部动脉的双工超声 结合其他研究评估将用于更好地解决人口 周围动脉疾病临床测试的不确定结果。结果将有助于指导 应用临床筛查方案和移动技术来识别，预测和 干预与PAD相关的主要健康序列。