PASOS: Peripheral Artery Disease Study of SOL. An ancillary study of the Hispanic Community Health Study/Study of Latinos

PASOS：SOL 的外周动脉疾病研究。

• 批准号: 10220120
• 负责人: Robert C Kaplan
• 金额: $ 215.68万
• 依托单位: ALBERT EINSTEIN COLLEGE OF MEDICINE
• 依托单位国家: 美国
• 财政年份: 2019
• 资助国家: 美国
• 起止时间: 2019-08-01 至 2023-07-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10220120
• 关键词: Accelerometer; Address; Adult; Adverse effects; Affect; Amputation; Ancillary Study; Ankle; Arteries; Blood Vessels; Cardiovascular system; Classification; Clinic; Clinical; Clinical assessments; Cohort Studies; Communities; Data; Detection; Diabetes Mellitus; Diagnosis; Diagnostic; Diagnostic tests; Disease; Disease Management; Eligibility Determination; Environment; Etiology; Event; Exercise; Exercise Therapy; Fatigue; General Population; Goals; Gold; Health; High Prevalence; Hispanic Community Health Study/Study of Latinos; Hispanics; Hospitalization; Independent Living; Individual; Intermittent Claudication; Ischemia; Leg; Link; Longitudinal cohort study; Lower Extremity; Maintenance; Measurement; Measures; Medial; Medicare; Monitor; Outcome; Pain-Free; Participant; Patient Self-Report; Patients; Pattern; Peripheral arterial disease; Persons; Physical Function; Physical activity; Population; Population Study; Prediabetes syndrome; Process; Quality of life; Questionnaires; Reporting; Rest; Risk; Risk Factors; Study of Latinos; Supervision; Symptoms; Testing; Time; Toes; Ultrasonography; United States National Institutes of Health; Visit; Walking; Wrist; aged; artery stenosis; base; calcification; clinical application; clinical risk; cohort; diabetic; disease diagnosis; high risk; indexing; insight; interest; meetings; mobile computing; mortality risk; prognostic value; prospective; research clinical testing; risk stratification; sedentary; sedentary lifestyle; wearable device

Lower extremity peripheral artery disease (PAD) affects 10 million adults in the US and increases the risk of mortality and leg amputation. Since it has broad implications for quality of life and maintenance of independent living, the impact of PAD on physical activity and function is of great interest. To characterize the impact of PAD on free-living daily physical activity and examine the value of objective assessment of daily physical activity for PAD management, diagnosis and risk stratification, we propose to evaluate enrollees of the Hispanic Community Cohort Study/Study of Latinos (HCHS/SOL). Participants who were originally studied during 2008-2011 will complete a return in person visit during 2019-2021. Through comprehensive clinical assessment of lower extremity blood vessels, multi-day accelerometry and physical function testing, we address the hypothesis that PAD will be identifiable by suboptimal usual activity patterns including longer sedentary time, higher activity fragmentation and diurnal patterns of activity. The study will also determine the prognostic value of 7-day physical activity, above and beyond self-reported leg symptoms and clinic-based physical function, to predict PAD-associated major health outcomes. Finally, duplex ultrasound of leg arteries in combination with other study assessments will be used to better resolve the population with indeterminant results on peripheral arterial disease clinical test. Results will help to guide the application of both clinical screening protocols and mobile technologies to identify, predict and intervene upon major health sequalae associated with PAD.

在美国，有1000万成年人患有下肢外周动脉疾病 增加死亡和截肢的风险。因为它对质量有广泛的影响 生活和独立生活的维持，PAD对身体活动和功能的影响 引起了极大的兴趣。为了表征PAD对自由生活日常身体活动的影响，以及 检查日常体力活动的客观评估对PAD管理的价值， 诊断和风险分层，我们建议评估西班牙裔社区的注册者 拉丁裔队列研究/研究(HCHS/SOL)。最初研究过的参与者 2008-2011年将在2019-2021年期间完成亲自访问。通过全面的 下肢血管的临床评估、多日加速度法和体格检查 功能测试，我们解决了PAD将通过次优通常可识别的假设 活动模式包括较长的久坐时间，较高的活动碎片化和日间 活动模式。这项研究还将确定7天体力活动的预后价值， 除了自我报告的腿部症状和基于临床的身体功能之外，还可以预测 与PAD相关的主要健康后果。最后，小腿动脉的双功能超声检查 与其他研究评估相结合将用于更好地解决 外周动脉疾病临床试验结果不确定。结果将有助于指导 应用临床筛查方案和移动技术来识别、预测和 干预与PAD相关的重大健康后遗症。