PASOS: Peripheral Artery Disease Study of SOL. An ancillary study of the Hispanic Community Health Study/Study of Latinos

下肢外周动脉疾病（PAD）影响美国1000万成年人， 增加了死亡和截肢的风险。由于它对质量有广泛的影响， 生活和维持独立生活，PAD对身体活动和功能的影响 很有意思描述PAD对自由生活日常体力活动的影响， 检查日常体力活动的客观评估对PAD管理的价值， 诊断和危险分层，我们建议评估西班牙裔社区的登记者 拉丁裔研究（HCHS/SOL）。参与者最初是在 2008-2011年将在2019-2021年期间完成一次回访。通过全面 下肢血管的临床评估，多日加速度计和物理 功能测试，我们解决了这一假设，即PAD将可识别的次优通常 活动模式包括久坐时间较长，活动碎片化程度较高， 活动模式。这项研究还将确定7天体力活动的预后价值， 除了自我报告的腿部症状和基于临床的身体功能之外， PAD相关的主要健康结局。最后，腿部动脉的多普勒超声检查， 与其他研究评估相结合，将用于更好地解决人群 外周动脉疾病临床试验结果不确定。结果将有助于指导 应用临床筛查方案和移动的技术， 干预与PAD相关的重大健康后遗症。

Lower extremity peripheral artery disease (PAD) affects 10 million adults in the US and increases the risk of mortality and leg amputation. Since it has broad implications for quality of life and maintenance of independent living, the impact of PAD on physical activity and function is of great interest. To characterize the impact of PAD on free-living daily physical activity and examine the value of objective assessment of daily physical activity for PAD management, diagnosis and risk stratification, we propose to evaluate enrollees of the Hispanic Community Cohort Study/Study of Latinos (HCHS/SOL). Participants who were originally studied during 2008-2011 will complete a return in person visit during 2019-2021. Through comprehensive clinical assessment of lower extremity blood vessels, multi-day accelerometry and physical function testing, we address the hypothesis that PAD will be identifiable by suboptimal usual activity patterns including longer sedentary time, higher activity fragmentation and diurnal patterns of activity. The study will also determine the prognostic value of 7-day physical activity, above and beyond self-reported leg symptoms and clinic-based physical function, to predict PAD-associated major health outcomes. Finally, duplex ultrasound of leg arteries in combination with other study assessments will be used to better resolve the population with indeterminant results on peripheral arterial disease clinical test. Results will help to guide the application of both clinical screening protocols and mobile technologies to identify, predict and intervene upon major health sequalae associated with PAD.