DRUG RESISTANCE TO INHIBITORS OF DNA TOPOISOMERASE II

对 DNA 拓扑异构酶 II 抑制剂的耐药性

• 批准号: 2429778
• 负责人: DANIEL M SULLIVAN
• 金额: $ 18.22万
• 依托单位: UNIVERSITY OF SOUTH FLORIDA
• 依托单位国家: 美国
• 财政年份: 1994
• 资助国家: 美国
• 起止时间: 1994-09-01 至 1999-05-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/2429778
• 关键词: CHO cells; DNA topoisomerases; antineoplastics; cell cycle; cytotoxicity; enzyme activity; enzyme inhibitors; gel electrophoresis; lung neoplasms; mitoxantrone; multidrug resistance; phosphorylation; protein purification; southern blotting; tissue /cell culture; western blottings

项目成果

Cell density-dependent VP-16 sensitivity of leukaemic cells is accompanied by the translocation of topoisomerase IIalpha from the nucleus to the cytoplasm.

白血病细胞的细胞密度依赖性 VP-16 敏感性伴随着拓扑异构酶 IIα 从细胞核易位到细胞质。

• DOI: 10.1046/j.1365-2141.2000.01832.x
• 发表时间: 2000
• 期刊: British journal of haematology
• 影响因子: 6.5
• 作者: Valkov,NI;Gump,JL;Engel,R;Sullivan,DM
• 通讯作者: Sullivan,DM

Drug resistance to DNA topoisomerase I and II inhibitors in human leukemia, lymphoma, and multiple myeloma.

人类白血病、淋巴瘤和多发性骨髓瘤对 DNA 拓扑异构酶 I 和 II 抑制剂的耐药性。

• 发表时间: 1997
• 期刊: Seminars in hematology.
• 作者: Valkov,NI;Sullivan,DM
• 通讯作者: Sullivan,DM