Conference: 2016 Gordon Research Seminar on DNA Topoisomerases to be held at Sunday River in Newry, ME on August 6-7, 2016

该奖项将支持研究生和博士后研究人员参加戈登DNA拓扑异构酶研究研讨会，该研讨会将于2016年8月6日至7日在缅因州纽里的Sunday River举行。会议由两位研究生组织并主持。会议的形式是演讲和海报的结合，这将促进正式和非正式环境中的科学交流。来自学术界、工业界和政府的研究人员将参加一个特别的结论性小组讨论，重点讨论该领域的未来职业。届时将有充分的机会分享最新的研究成果并探索合作的可能性。DNA拓扑异构酶在DNA复制和转录过程中对染色体动力学起着至关重要的作用。拓扑异构酶的研究领域尤其多样化，包括物理学、化学、结构生物学、纳米生物学、微生物学、生物化学、药物发现、癌症生物学和医学等方面。该领域的最新进展反映了这种多样性，并将在本次会议上得到强调。讨论的主题将包括允许解剖酶- dna相互作用的技术创新，应用结构生物学方法来理解酶动力学和机制，以及使用成像和其他技术来揭示这些酶的细胞作用，从而能够开发控制其活性的新工具。从摘要和海报中选择的简短谈话将强调前沿或最新的研究。特别注意鼓励来自代表性不足群体的科学家参与。会议将提供一个极好的论坛，促进具有共同专业兴趣的早期职业科学家之间的讨论，促进这个令人兴奋的领域的思想交流，并使科学合作朝着新的方向发展。

This award will support attendance by graduate students and postdoctoral researchers at the Gordon Research Seminar on DNA Topoisomerases to be held at Sunday River in Newry, ME on August 6-7, 2016. The meeting was organized and will be chaired by two graduate students. The format of the meeting is a combination of talks and posters, which will promote scientific exchange in both formal and informal settings. A special concluding panel discussion with researchers from academia, industry and government will focus on future careers in the field. There will be ample opportunity for sharing latest research results and for exploring collaborative possibilities. DNA topoisomerases play crucial roles in chromosome dynamics during the processes of DNA replication and transcription. The field of topoisomerase research is especially diverse, encompassing aspects of physics, chemistry, structural biology, nanobiology, microbiology, biochemistry, drug discovery, cancer biology, and medicine. Recent advances in the field reflect this diversity and will be highlighted in this conference. Topics for discussion will include technological innovations that allow dissection of enzyme-DNA interactions, application of structural biology approaches to understand enzyme dynamics and mechanisms, and use of imaging and other technologies to reveal cellular roles for these enzymes that could enable development of novel tools for controlling their activities. Cutting-edge or late-breaking research will be highlighted in short talks chosen from the abstracts and in posters. Special attention has been given to encourage participation by scientists from underrepresented groups. The conference will provide an excellent forum to promote discussion between early-career scientists with common professional interests, to foster exchange of ideas across this exciting field, and to enable scientific collaborations to evolve in new directions.