权益分类	功能权益	普通用户	{{item.name}}会员
{{category.name}}	{{benefitItem.name}}

PHYSIOCHEMICAL REGULATION OF RETINAL HEMODYNAMICS

视网膜血流动力学的物理化学调节

基本信息

批准号：
2545868
负责人：
ALON HARRIS
金额：
$ 10.65万
依托单位：
INDIANA UNIV-PURDUE UNIV AT INDIANAPOLIS
依托单位国家：
美国
项目类别：
财政年份：
1993
资助国家：
美国
起止时间：
1993-09-30 至 1998-09-29
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/2545868
关键词：
blood glucose carbon dioxide tension diabetic retinopathy exercise eye circulation eye pharmacology glaucoma hemodynamics human subject intraocular pressure oxygen tension retina visual perception

项目摘要

Physiochemical factors profoundly influence the metabolic status of the eye, yet most are poorly defined. This application involves investigation into several systemic factors that may alter retinal and cerebral hemodynamics, the objective being first to define the normal regulatory response, so that regulatory dysfunctions that exist in diabetic or glaucomatous eyes can be characterized. The first specific aim is to define the independent ocular effects of variations in systemic O2, CO2, and exercise level. Total retinal blood flow, mean retinal capillary flow velocity, the inhOmogeneity of retinal capillary flow rates, the perifoveal intercapillary distance, and the size of the foveal avascular zone will be measured with a scanning laser ophthalmoscope. Intraocular pressure, using Goldmann applanation tonometry, along with testing of contrast sensitivity and visual acuity, will further define the ocular response. Carotid and ophthalmic arterial blood flow, measured using color doppler imaging, will provide the second specific aim of defining the relationship of ocular hemodynamics to regional perfusion. The third goal of the proposed research is to determine the differences in retinal and regional circulatory regulatory response to O2, CO2, and exercise among diabetic patients without retinopathy, patients with diabetes and ophthalmoscopic evidence of retinopathy, and age-matched healthy persons. A fourth aim is to define how varying levels of blood glucose, in age-matched control as compared with diabetic patients, affect retinal and cerebral regulatory responses. Retinal and cerebral circulatory regulation in healthy as compared with glaucomatous eyes will comprise the fifth specific aim. A subgroup of persons with ocular hypertension but without glaucoma will be included. Both hypocapnia and moderate exercise acutely lower intraocular pressure: it is hypothesized that these stimuli may significantly enhance retinal flow in ocular hypertensives and glaucoma patients. The final specific aim is to define how drugs (a non-selective beta-adrenergic blocker, a selective beta1-adrenergic blocker, and a topical carbonic anhydrase inhibitor) that are known to lower intraocular pressure, affect retinal, ophthalmic, and cerebral flow regulation in healthy eyes, both young and old. These proposed studies will be the first to simultaneously investigate retinal, ophthalmic, and cerebral blood flow regulation. Placing the retinal circulation in its regional context will advance understanding of the pathophysiology of diabetic retinopathy and glaucoma, and of the mechanisms by which topical ocular hypotensive drugs exert their actions. This understanding may expedite development of new vasoactive compounds to treat eye diseases.

生理化学因素深刻地影响了代谢状态的眼睛，但大多数人都不清楚。这项申请涉及调查几个系统因素，可能会改变视网膜和大脑血流动力学，目的是首先确定正常的调节反应，使调节功能障碍，存在于糖尿病或可以描述青光眼的特征。第一个具体的目的是确定独立的眼睛的影响，全身O2、CO2和运动水平的变化。全视网膜血视网膜毛细血管平均血流速度、视网膜微血管内皮细胞的抑制毛细血管流速、中央凹周围毛细血管间距和大小将用扫描激光测量中心凹无血管区的面积检眼镜眼内压，使用Goldmann压平法眼压测量，沿着对比敏感度和视敏度的测试，将进一步定义眼部反应。颈动脉和眼动脉使用彩色多普勒成像测量的血流将提供第二个明确眼部血流动力学与局部灌注本研究的第三个目标是确定视网膜和局部循环对O2、CO2和运动对无视网膜病变的糖尿病患者，糖尿病和视网膜病变的检眼镜证据，并且年龄匹配健康的人。第四个目标是确定不同水平的血液与糖尿病患者相比，在年龄匹配的对照组中，视网膜和大脑的调节反应。正常人视网膜和脑循环调节功能的比较青光眼将构成第五个特定目标。的子组将包括患有高眼压但没有青光眼的人。低碳酸血症和适度运动都能显著降低眼内压：假设这些刺激可以显著地增强视网膜的高眼压和青光眼患者的血流。最终的具体目标是定义药物（一种非选择性β-肾上腺素能阻滞剂，选择性β 1-肾上腺素能阻滞剂和局部碳酸酐酶抑制剂），其已知降低眼内压，影响视网膜，眼和脑血流调节在健康的眼睛，无论是年轻的，老了这些拟议的研究将是第一个同时调查视网膜、眼和脑血流调节。放置视网膜循环在其区域范围内将促进了解，糖尿病视网膜病变和青光眼的病理生理学，以及局部眼部消肿药物发挥作用的机制。这种理解可能会加速新的血管活性化合物的开发，治疗眼疾。

项目成果

期刊论文数量（12）

专著数量（0）

科研奖励数量（0）

会议论文数量（0）

专利数量（0）

[Retinal hemodynamics in patients with normal pressure glaucoma. Quantification with digital laser scanning fluorescein angiography].

常压青光眼患者的视网膜血流动力学。

DOI：
10.1007/s003470050371
发表时间：
1999
期刊：
Der Ophthalmologe : Zeitschrift der Deutschen Ophthalmologischen Gesellschaft
影响因子：
0
作者：
Arend,O;Remky,A;Redbrake,C;Arend,S;Wenzel,M;Harris,A
通讯作者：
Harris,A

Retinal blood flow indices in patients infected with human immunodeficiency virus.

人类免疫缺陷病毒感染患者的视网膜血流指数。