MODULATION OF SENSORY TRANSMISSION IN THE THALAMUS

丘脑网状核（TRN）被认为在神经元的活动中起着重要的作用 在认知中，通过调节预定用于大脑的感觉信息， 皮层 这种感觉信息的门控似乎是 维持注意力和产生波形活动的正常过程 睡眠的特点。 TRN的缺失，或TRN的区域 投射到TRN的大脑，与许多 神经病理状况 这些症状包括注意力缺陷 疾病、失神（癫痫小发作）和阿尔茨海默病。 关键 关于“技术中继网络”的数据是有限的，而且许多基本问题仍然存在 悬而未决 我们建议使用互补的神经解剖学和 电生理学的方法来彻底分析的视觉部门 粗尾Galago crassicaudatus的TRN。 从拟议的数据中获得的数据 这些研究将大大促进我们对 TRN在正常和病理条件下。

The thalamic reticular nucleus (TRN) is believed to play an important role in cognition by modulating the sensory information destined for cerebral cortex. This gating of sensory information appears fundamental to the normal processes of maintaining attention and generating waveform activity characteristic of sleep. Abnormalities of the TRN, or regions of the brain that project to the TRN, are implicated in a number of neuropathological conditions. Such conditions include attention deficit disorders, absence (petit mal) epilepsy, and Alzheimer's disease. Crucial data regarding the TRN are limited and many fundamental questions remain unresolved. We propose to use complementary neuroanatomical and electrophysiological methods to thoroughly analyze the visual sector of the TRN in Galago crassicaudatus. The data obtained from the proposed studies will significantly advance our understanding of the role of the TRN in normal and pathological conditions.