MODULATION OF SENSORY TRANSMISSION IN THE THALAMUS

丘脑网状核(TRN)被认为起着重要作用 通过调节指定给大脑的感觉信息在认知中 大脑皮层。这种感官信息的门控似乎是 保持注意力和产生波形活动的正常过程 以睡眠为特征的。TRN的异常，或 投射到TRN的大脑与许多 神经病理情况。这种情况包括注意力缺陷。 精神障碍、失神(小)癫痫和阿尔茨海默病。至关重要 关于TRN的数据有限，许多基本问题仍然存在 悬而未决。我们建议使用互补的神经解剖学和 电生理学方法彻底分析视区 粗尾加拉戈的TRN。从建议中获得的数据 研究将极大地促进我们对 正常和病理状态下的TRN。

The thalamic reticular nucleus (TRN) is believed to play an important role in cognition by modulating the sensory information destined for cerebral cortex. This gating of sensory information appears fundamental to the normal processes of maintaining attention and generating waveform activity characteristic of sleep. Abnormalities of the TRN, or regions of the brain that project to the TRN, are implicated in a number of neuropathological conditions. Such conditions include attention deficit disorders, absence (petit mal) epilepsy, and Alzheimer's disease. Crucial data regarding the TRN are limited and many fundamental questions remain unresolved. We propose to use complementary neuroanatomical and electrophysiological methods to thoroughly analyze the visual sector of the TRN in Galago crassicaudatus. The data obtained from the proposed studies will significantly advance our understanding of the role of the TRN in normal and pathological conditions.