MODULATION OF SENSORY TRANSMISSION IN THE THALAMUS

丘脑感觉传递的调节

• 批准号: 2391753
• 负责人: DANIEL J UHLRICH
• 金额: $ 17.71万
• 依托单位: UNIVERSITY OF WISCONSIN-MADISON
• 依托单位国家: 美国
• 财政年份: 1995
• 资助国家: 美国
• 起止时间: 1995-04-01 至 1999-03-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/2391753
• 关键词: Prosimii; axon; brain electrical activity; brain mapping; gamma aminobutyrate; immunocytochemistry; intercellular connection; lateral geniculate body; neuronal transport; pulvinar thalami; synapses; thalamic nuclei; vision tests; visual fields; visual pathways

The thalamic reticular nucleus (TRN) is believed to play an important role in cognition by modulating the sensory information destined for cerebral cortex. This gating of sensory information appears fundamental to the normal processes of maintaining attention and generating waveform activity characteristic of sleep. Abnormalities of the TRN, or regions of the brain that project to the TRN, are implicated in a number of neuropathological conditions. Such conditions include attention deficit disorders, absence (petit mal) epilepsy, and Alzheimer's disease. Crucial data regarding the TRN are limited and many fundamental questions remain unresolved. We propose to use complementary neuroanatomical and electrophysiological methods to thoroughly analyze the visual sector of the TRN in Galago crassicaudatus. The data obtained from the proposed studies will significantly advance our understanding of the role of the TRN in normal and pathological conditions.

丘脑网状核（TRN）被认为发挥着重要作用 通过调节送往大脑的感觉信息来进行认知 皮质。 这种感觉信息的门控对于 维持注意力和产生波形活动的正常过程 睡眠的特点。 TRN 或区域的异常 投射到 TRN 的大脑与许多 神经病理学状况。 这些情况包括注意力缺陷 疾病、失神（小病）癫痫和阿尔茨海默病。 至关重要的 有关 TRN 的数据有限，仍然存在许多基本问题 未解决。 我们建议使用互补的神经解剖学和 电生理方法彻底分析视觉区域 Galago crassicaudatus 中的 TRN。 从建议中获得的数据 研究将极大地增进我们对它的作用的理解 正常和病理条件下的 TRN。