CONTROL OF CENTRAL VISUAL PATHWAYS BY THE BRAINSTEMS

脑干对中央视觉通路的控制

• 批准号: 3263033
• 负责人: DANIEL J UHLRICH
• 金额: $ 9.52万
• 依托单位: UNIVERSITY OF WISCONSIN-MADISON
• 依托单位国家: 美国
• 财政年份: 1990
• 资助国家: 美国
• 起止时间: 1990-07-01 至 1995-03-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/3263033
• 关键词: biophysics; brain stem; cats; dorsal raphe nucleus; electron microscopy; electrophysiology; histology; lateral geniculate body; locus coeruleus; microscopy; neural information processing; neuroanatomy; neurophysiology; optic tract; synapses; visual feedback; visual pathways; visual perception; visual stimulus

The thalamic lateral geniculate nucleus (LGN) is found in the primary neural pathway between the eye and visual cortex, and it controls the flow of visual information to the brain in large measure through the influence of specific nuclei in the brainstem. Pathways from the brainstem can powerfully effect the LGN and are believed to reflect behavioral states, such as arousal or attention and the occurrence of eye movements. HOwever, the anatomy and physiology of these brainstem circuits are not well understood. This research will provide a comprehensive, multi-disciplinary description of the structural and functional influences of the brainstem on the LGN. In doing so, these studies will elucidate, more generally, the role of the thalamus in relaying sensory information to the e cortex, and they will aid in understanding the role of a key neural element underlying vision. Aims 1 and 3 are to demonstrate the effects of electrical and chemical activation of individual brainstem nuclei on the extra- and intracellular responses of LGN cells to visual stimuli. Aims 2 and 4 are to describe, at the light and electron microscopic level by means of retrograde and anterograde tracers, the morphology and ultrastructure of brainstem neurons that project to the LGN and other thalamic nuclei. Aim 5 is to confirm and describe key thalamic pathways through which the brainstem indirectly controls the LGN.

丘脑外侧膝状核（LGN）位于初级

项目成果

The histaminergic innervation of the lateral geniculate complex in the cat.

猫外侧膝状体复合体的组胺能神经支配。

• DOI: 10.1017/s0952523800003631
• 发表时间: 1993
• 期刊: Visual neuroscience
• 影响因子: 1.9
• 作者: Uhlrich,DJ;Manning,KA;Pienkowski,TP
• 通讯作者: Pienkowski,TP

Phaseolus vulgaris leucoagglutinin (PHA-L): a neuroanatomical tracer for electron microscopic analysis of synaptic circuitry in the cat's dorsal lateral geniculate nucleus.

菜豆白细胞凝集素 (PHA-L)：一种神经解剖学示踪剂，用于电子显微镜分析猫背外侧膝状体突触回路。

• DOI: 10.1002/jemt.1060150405
• 发表时间: 1990
• 期刊: Journal of electron microscopy technique
• 作者: Cucchiaro,JB;Uhlrich,DJ
• 通讯作者: Uhlrich,DJ

Nicotinic receptor-mediated responses in relay cells and interneurons in the rat lateral geniculate nucleus.

烟碱受体介导的大鼠外侧膝状核中继细胞和中间神经元的反应。

• DOI: 10.1016/s0306-4522(97)00095-x
• 发表时间: 1997
• 期刊: Neuroscience
• 影响因子: 3.3
• 作者: Zhu,JJ;Uhlrich,DJ
• 通讯作者: Uhlrich,DJ

Cellular mechanisms underlying two muscarinic receptor-mediated depolarizing responses in relay cells of the rat lateral geniculate nucleus.

大鼠外侧膝状核中继细胞中两种毒蕈碱受体介导的去极化反应的细胞机制。

• DOI: 10.1016/s0306-4522(98)00209-7
• 发表时间: 1998
• 期刊: Neuroscience
• 影响因子: 3.3
• 作者: Zhu,JJ;Uhlrich,DJ
• 通讯作者: Uhlrich,DJ

The distribution of histaminergic axons in the superior colliculus of the cat.

猫上丘组胺能轴突的分布。

• DOI: 10.1016/0306-4522(93)90321-6
• 发表时间: 1993
• 期刊: Neuroscience
• 影响因子: 3.3
• 作者: Manning,KA;Uhlrich,DJ
• 通讯作者: Uhlrich,DJ