Affinity-based profiling of bacterial Fe(III)-siderophore receptors: design strategies for antibiotics and iron overload

基于亲和力的细菌 Fe(III)-铁载体受体分析：抗生素和铁过载的设计策略

• 批准号: nhmrc : 570844
• 负责人: Prof Rachel Codd
• 金额: $ 18.34万
• 依托单位: The University of Sydney
• 依托单位国家: 澳大利亚
• 项目类别: NHMRC Project Grants
• 财政年份: 2009
• 资助国家: 澳大利亚
• 起止时间: 2009-01-01 至 2012-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/affinity-based-profiling-iron-overload/95192
• 关键词: Affinity; based; profiling; bacterial; Fe

In order to establish an infection, bacteria compete with the host for iron, which is in scarce supply. To access iron, bacteria produce compounds called siderophores which bind iron strongly. The iron-siderophore complex, which is unique to each bacterium, is recognised by specific receptors at the bacterial cell-surface and imported for use. In this project, we are using modified siderophores as platforms for bacteria-specific drug design with the aim of producing new antibiotics.

为了建立感染，细菌与宿主竞争铁，而铁是稀缺的。为了获得铁，细菌产生一种叫做铁载体的化合物，这种化合物强烈地结合铁。铁-铁载体复合物是每种细菌所特有的，被细菌细胞表面的特异性受体识别并输入使用。在这个项目中，我们使用修饰的铁载体作为细菌特异性药物设计的平台，目的是生产新的抗生素。