Mixing the jigsaw pieces of natural products: new molecules-new properties

混合天然产物的拼图：新分子-新特性

• 批准号: DP180100785
• 负责人: Prof Rachel Codd
• 金额: $ 29.15万
• 依托单位: The University of Sydney
• 依托单位国家: 澳大利亚
• 项目类别: Discovery Projects
• 财政年份: 2018
• 资助国家: 澳大利亚
• 起止时间: 2018-01-01 至 2022-12-31
• 项目状态: 已结题
• 来源: https://dataportal.arc.gov.au/RGS/Web/Grants/DP180100785
• 关键词: Mixing; jigsaw; pieces; natural; products

This project aims to examine the capacity of exploiting the bacterial biosynthetic machinery to fast-track access to analogues of natural products. Due to increased drug resistance, new reservoirs of natural products are needed for evaluation as future drugs. Desferrioxamine B will be used as a model natural product to establish the biosynthesis of new analogues in bacterial culture supplemented with unsaturated, fluorinated or deuterated building blocks. The intended outcomes are to deliver advances in methods for generating structurally diverse pools of natural products, new label-free probes, knowledge of natural product biosynthesis, and excellence in training research students in frontier methods in chemical biology and drug discovery.

该项目旨在研究利用细菌生物合成机制快速获取天然产物类似物的能力。由于耐药性增加，需要新的天然产物储库来评估未来的药物。去铁敏 B 将用作天然产物模型，在补充有不饱和、氟化或氘代结构单元的细菌培养物中建立新类似物的生物合成。预期成果是在生成结构多样的天然产物库、新的无标记探针、天然产物生物合成知识以及在化学生物学和药物发现前沿方法方面对研究生进行卓越培训方面取得进展。