SITE SPECIFIC ORAL AIDS MANIFESTATIONS

口腔中的病变是最早记录的艾滋病毒特征之一 感染 很少有精心设计的研究， 艾滋病毒在妇女中的表现。 在位于旧金山的加州大学， 弗朗西斯科口腔艾滋病中心（OAC），我们已经检查了数百名艾滋病毒 患者和研究参与者，主要是同性恋或双性恋男性。监督咨询委员 在过去的六年里， 哪些口腔病变与HIV感染有关， 男性艾滋病发展的预后意义。 我们将 现在更精确地确定口腔病变在整体中的位置， 女性疾病进展的模式。 具体而言，我们将：1） 确定口腔病变与HIV感染之间的关系， 口腔病变与免疫功能低下程度的关系 抑制; 2）确定口腔病变的预后意义 艾滋病的发展和生存; 3）确定是否某些 行为和治疗增加或减少 发展中的具体病变;和4）确定的差异， 女性口腔病变的发生率和预后意义， 男性历史案例 这项研究将建立在我们的广泛经验， 口腔病变的特征，口腔结果的评估， 疾病进展的背景，以及这些数据的统计分析 调查结果。

Lesions in the mouth were among the first documented features of HIV infection. There have been few well-designed studies of the oral manifestations of HIV among women. At the University of California, San Francisco Oral AIDS Center (OAC), we have examined hundreds of HIV patients and study participants, mostly gay or bisexual men. The OAC has, during the last six years, developed a good understanding as to which oral lesions are associated with HIV infection and their prognostic significance for the development of AIDS among men. We will now more precisely determine where oral lesions fit in the overall pattern of disease progression in women. More specifically we will: 1) Determine the relationship between oral lesions and HIV infection, and the association between oral lesions and the degree of immune suppression; 2) Determine the prognostic significance of oral lesions for the development of AIDS and survival; 3) Determine whether certain behaviors and treatments increase or decrease the likelihood of developing specific lesions; and 4) Determine the differences in the occurrence and prognostic significance of oral lesions among women and male historical cases. This research will build upon our extensive experience in the characterization of oral lesions, the assessment of oral findings in the context of disease progression, and the statistical analyses of these findings.