Harvard University Center for AIDS Research

哈佛大学艾滋病研究中心

• 批准号: 10912098
• 负责人: RAJESH T GANDHI
• 金额: $ 54.55万
• 依托单位: HARVARD UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2004
• 资助国家: 美国
• 起止时间: 2004-07-01 至 2024-07-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10912098
• 关键词: Acquired Immunodeficiency Syndrome; Address; Adolescent; Africa; Aging; Animal Model; Basic Science; Behavioral; Bioinformatics; Biometry; Boston; Clinical; Clinical Research; Collaborations; Communities; Consultations; Core Facility; Country; Dana-Farber Cancer Institute; Development; Epidemic; Epidemiology; Funding; Funding Mechanisms; General Hospitals; Generations; Goals; HIV; HIV Infections; HIV vaccine; HIV/AIDS; Health; Hospitals; Human; Immune response; Immune system; Immunity; Infection; Infrastructure; Institution; Interdisciplinary Study; International; Israel; Leadership; Link; Massachusetts; Medical center; Mentors; Mentorship; Methodology; Mission; Modeling; Molecular Virology; Mus; Pathogenesis; Patients; Pediatric Hospitals; Persons; Pilot Projects; Play; Population; Population Research; Prevention; Privatization; Process; Public Health; Public Health Schools; Reporting; Reproductive Health; Research; Research Personnel; Research Priority; Research Project Grants; Research Support; Resources; Role; Schools; Services; Site; Strategic Planning; Sum; Technology; Training and Education; Translational Research; United States National Institutes of Health; Universities; Vaccine Research; Vaccines; Woman; base; biobehavior; career; catalyst; cohort; community engagement; community science; efficacy trial; flexibility; health economics; human model; implementation science; innovation; inter-institutional; laboratory equipment; medical schools; meetings; member; multidisciplinary; next generation; programs; reproductive health of adolescents; success; synergism; vaccine candidate; working group

PROJECT SUMMARY/ABSTRACT Overall This application proposes continued funding of the Harvard University Center for AIDS Research (HU CFAR). HU CFAR is the umbrella organization for all AIDS research at Harvard, operating out of the Provost's Office. It represents each of the Harvard affiliated schools as well as the affiliated hospitals, including Dana-Farber Cancer Institute, Beth Israel Deaconess Medical Center, Boston Children's Hospital, Massachusetts General Hospital, Brigham & Women's Hospital. In addition, it includes Fenway Health, extending its reach to additional clinical populations and translational research sites outside Harvard. HU CFAR builds collaborations and provides infrastructure support to coordinate and promote emerging opportunities in basic, clinical, behavioral, translational and implementation HIV research. Research emphasis among investigators includes studies of molecular virology, pathogenesis, host immune responses, epidemiology, treatment, vaccines prevention and delivery. CFAR also oversees 4 Scientific Programs (Health Economics and Modeling; HIV Vaccines; HIV Eradication) as well as 3 Scientific Working Groups (Adolescents and HIV, HIV and Aging; Reproductive Health for HIV-Infected Populations). Five core facilities have also been identified for HU CFAR support: Clinical Core, Biostatistics and Bioinformatics Core, Human Immune System Mouse, Core Advanced Laboratory Technologies Core, Bio-Behavioral and Community Science Core. In addition, an Administrative Core will provide strategic planning and fiscal oversight, and a Developmental and Mentoring Core will support innovative pilot projects related to the goals of the scientific programs and scientific working groups, and provide mentorship to develop the next generation of HIV researchers. Undertaking the following specific aims, the HU CFAR will continue to evolve, to meet the needs of its members and the NIH AIDS research priorities by promoting and facilitating collaborative, cross-disciplinary activities in AIDS research among CFAR members, serving as a model for collaborative inter-institutional interactions at Harvard. Briefly, we propose to: 1. Facilitate and expand synergistic multidisciplinary collaborations among the diverse and highly successful HU-affiliated HIV/AIDS researchers and their trainees 2. Promote new interactions and support innovative research initiatives capable of more effectively addressing key HIV/AIDS related research questions aimed at bringing an end to the epidemic 3. Attract, engage, support and mentor the next generation of Early Career Investigators in HIV/AIDS research

项目总结/摘要 整体 本申请建议继续资助哈佛大学艾滋病研究中心（HU CFAR）。 HU CFAR是哈佛所有艾滋病研究的伞式组织，在教务长办公室外运作。 它代表了哈佛的每一所附属学校以及附属医院，包括达纳法伯 癌症研究所，贝斯以色列女执事医疗中心，波士顿儿童医院，马萨诸塞州总医院 布里格姆妇女医院Brigham & Women's Hospital此外，它还包括芬威健康，将其范围扩大到其他 临床人群和哈佛以外的转化研究基地。HU CFAR建立合作， 提供基础设施支持，以协调和促进基础，临床，行为， 转化和实施艾滋病毒研究。研究者的研究重点包括以下研究： 分子病毒学、发病机理、宿主免疫应答、流行病学、治疗、疫苗预防和 交付. CFAR还监督4个科学项目（卫生经济学和建模;艾滋病毒疫苗;艾滋病毒 以及3个科学工作组（青少年与艾滋病毒、艾滋病毒与老龄化;生殖健康和生殖健康）。 艾滋病毒感染者的健康）。还为HU CFAR支持确定了五个核心设施： 临床核心，生物统计学和生物信息学核心，人类免疫系统小鼠，核心高级 实验室技术核心，生物行为和社区科学核心。此外，行政 核心将提供战略规划和财政监督，发展和指导核心将支持 与科学方案和科学工作组的目标有关的创新试点项目，以及 为培养下一代艾滋病毒研究人员提供指导。开展以下具体工作： 为了实现这一目标，HU CFAR将继续发展，以满足其成员和NIH艾滋病研究的需求 通过促进和便利艾滋病研究合作和跨学科活动， 成员，作为一个模式，合作机构间的互动在哈佛。简而言之，我们建议： 1.促进和扩大不同和高度发达国家之间的协同多学科合作 成功的大学附属艾滋病毒/艾滋病研究人员及其受训人员 2.促进新的互动，支持能够更有效地 解决与艾滋病毒/艾滋病有关的关键研究问题，旨在结束这一流行病 3.吸引、参与、支持和指导下一代艾滋病毒/艾滋病早期职业调查人员 研究

项目成果

"That was our afterparty": a qualitative study of mobile, venue-based PrEP for MSM.

“那是我们的派对”：一项针对MSM的基于移动的，基于MOB的PREP的定性研究。

• DOI: 10.1186/s12913-023-09475-8
• 发表时间: 2023-05-17
• 期刊: BMC HEALTH SERVICES RESEARCH
• 影响因子: 2.8
• 作者: Chamberlin, Grace;Lopes, Mairead Day;Iyer, Surabhi;Psaros, Christina;Bassett, Ingrid V.;Medeiros, Susana;O'Connor, Catherine;Ard, Kevin L.
• 通讯作者: Ard, Kevin L.

Magnitude and Kinetics of CD8+ T Cell Activation during Hyperacute HIV Infection Impact Viral Set Point.

• DOI: 10.1016/j.immuni.2015.08.012
• 发表时间: 2015-09-15
• 期刊: Immunity
• 影响因子: 32.4
• 作者: Ndhlovu ZM;Kamya P;Mewalal N;Kløverpris HN;Nkosi T;Pretorius K;Laher F;Ogunshola F;Chopera D;Shekhar K;Ghebremichael M;Ismail N;Moodley A;Malik A;Leslie A;Goulder PJ;Buus S;Chakraborty A;Dong K;Ndung'u T;Walker BD
• 通讯作者: Walker BD

Development and validation of the HIV adolescent readiness for transition scale (HARTS) in South Africa.

南非艾滋病毒青少年过渡准备量表 (HARTS) 的开发和验证。

• DOI: 10.1002/jia2.25767
• 发表时间: 2021-07
• 期刊: Journal of the International AIDS Society
• 影响因子: 6
• 作者: Zanoni BC;Archary M;Sibaya T;Musinguzi N;Kelley ME;McManus S;Haberer JE
• 通讯作者: Haberer JE

Designing a sexual network study of men who have sex with other men: exploring racial and ethnic preferences in study design and methods.

• DOI: 10.1080/09540121.2016.1198748
• 发表时间: 2017-01
• 期刊: AIDS care
• 影响因子: 1.7
• 作者: Biello KB;Malone J;Mayer KH;Bazzi AR;Mimiaga MJ
• 通讯作者: Mimiaga MJ

Hepatic immunopathology during occult hepacivirus re-infection.

• DOI: 10.1016/j.virol.2017.08.037
• 发表时间: 2017-12
• 期刊: Virology
• 影响因子: 3.7
• 作者: Manickam C;Martinot AJ;Jones RA;Varner V;Reeves RK
• 通讯作者: Reeves RK