IMMUNE MECHANISMS OF PROTECTION AGAINST MYCOBACTERIUM TUBERCULOSIS CENTER (IMPAC-TB)
IMMUNE MECHANISMS OF PROTECTION AGAINST MYCOBACTERIUM TUBERCULOSIS CENTER (IMPAC-TB)
批准号:
10925119
负责人:
SARAH FORTUNE
金额:
$874.28万
依托单位国家:
美国
项目类别:
财政年份:
2019
资助国家:
美国
项目状态:
未结题
起止时间:
2019-09-30 至 2025-09-29
关键词:
Animal ModelAnimalsComputer ModelsGoalsHIVHumanImmuneImmune EvasionImmune TargetingImmune responseImmunityImmunologicsMusMycobacterium InfectionsMycobacterium tuberculosisResearch ActivityResearch PersonnelSIVSamplingTechnologyTestingTissuesTranslatingTuberculosisTuberculosis Vaccinescohortimprovedmultidisciplinarynon-tuberculosis mycobacterianonhuman primateprogramsresponsevaccine strategy
中文摘要
该计划的目标是建立一个由高度协作的研究人员组成的综合多学科团队,该团队将对小动物、非人灵长类动物(NHPs)和人类的组织特异性和系统性反应进行迭代和深入的免疫分析,以确定预防结核分枝杆菌所需的关键免疫反应;确定可用于改进结核病疫苗策略的免疫靶点。该计划下的其他研究活动可能包括确定艾滋病毒/SIV和非结核分枝杆菌(NTM)感染对结核分枝杆菌感染或结核疫苗的相关免疫反应的影响,并确定细菌免疫逃避机制如何破坏对结核分枝杆菌的免疫反应。
英文摘要
The goal of this program is to establish an integrated multi-disciplinary team of highly collaborative investigators that will plan and conduct iterative, in-depth immunologic analyses of tissue-specific and systemic responses in small animals, non-human primates (NHPs), and humans to identify the key immune responses needed for protection against Mtb; identify immunologic targets that can be used to improve TB vaccine strategies. Other research activities under the program may include determining the impact of HIV/SIV and Nontuberculous Mycobacteria (NTM) infection(s) on relevant immune responses to Mtb infection or TB vaccines and identifying how bacterial immune evasion mechanisms subvert immune responses to Mtb.
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会议论文
Establishing the Genetic Basis of Altered Drug Responses in Mycobacterium tuberculosis
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批准号:10595538
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资助金额:$164.79万
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财政年份:2019
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负责人:SARAH FORTUNE
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Establishing the Genetic Basis of Altered Drug Responses in Mycobacterium tuberculosis
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财政年份:2019
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依托单位:
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批准号:10027082
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批准号:10691842
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资助金额:$20.0万
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财政年份:2007
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负责人:SARAH FORTUNE
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依托单位:
Variation in M. tuberculosis in response to host selection
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财政年份:2007
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负责人:SARAH FORTUNE
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依托单位:
Variation in M. tuberculosis in response to host selection
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项目类别:
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资助金额:$10.0万
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依托单位:
M tuberculosis evasion of the innate immune response
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财政年份:2002
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负责人:SARAH FORTUNE
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依托单位:
M tuberculosis evasion of the innate immune response
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项目类别:
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资助金额:$12.23万
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财政年份:2002
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依托单位:
M tuberculosis evasion of the innate immune response
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资助金额:$12.23万
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Bacterial Determinants of Tuberculosis Susceptibiliy
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Develomental Core
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资助金额:$63.17万
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财政年份:--
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依托单位:
Establishing the Genetic Basis of Altered Drug Responses in Mycobacterium tuberculosis
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财政年份:--
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负责人:SARAH FORTUNE
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依托单位:
海外基金