Neuromodulation for Enhancement of Emotion Regulation in Bipolar Mood Disorders

神经调节增强双相情感障碍的情绪调节

• 批准号: 10617725
• 负责人: Kristen K Ellard
• 金额: $ 19.93万
• 依托单位: MASSACHUSETTS GENERAL HOSPITAL
• 依托单位国家: 美国
• 财政年份: 2020
• 资助国家: 美国
• 起止时间: 2020-05-01 至 2025-04-30
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10617725
• 关键词: Address; Anatomy; Anterior; Aversive Stimulus; Behavioral; Bipolar Disorder; Brain; Chronic; Clinical; Cognitive Therapy; Computer Assisted; Computer Systems; Data; Development; Distress; Dorsal; Dose; Electromagnetics; Emotional; Emotions; Ensure; Feeling suicidal; Functional Magnetic Resonance Imaging; Functional disorder; Future; Goals; Health Care Costs; Individual; Inferior; Insula of Reil; Intervention; Investigation; Literature; Magnetic Resonance; Maintenance; Mentors; Mood Disorders; Network-based; Neuronavigation; Neurosciences; Outcome; Parietal Lobe; Participant; Pathology; Pathway Analysis; Patients; Pattern; Performance; Physiologic pulse; Prefrontal Cortex; Productivity; Psychopathology; Public Health; Randomized; Reaction Time; Research; Research Proposals; Site; Statistical Methods; Synapses; Techniques; Technology; Testing; Training; Transcranial magnetic stimulation; Work; behavioral response; bipolar patients; clinical translation; cognitive reappraisal; cohort; efficacy testing; emotion dysregulation; emotion regulation; executive function; experience; functional MRI scan; improved; individual patient; innovation; neural; neural circuit; neuroimaging; neuroregulation; pharmacologic; precision medicine; programs; psychopharmacologic; psychosocial; recruit; response; specific biomarkers; success; suicidal behavior; tool; treatment strategy

PROJECT SUMMARY/ABSTRACT Individuals with bipolar mood disorders (BD) experience severe and episodic emotion dysregulation. Our existing pharmacological and psychosocial treatments fail to normalize emotion dysregulation for many bipolar patients. We need new and innovative approaches to help improve emotion dysregulation for these patients. The long-term goal of this proposal is to understand the pathophysiology of emotion dysregulation in BD, and to develop strategies to directly target and improve emotion regulation capacity. To this end, the candidate proposes: (1) training objectives to acquire expertise in advanced network-based analysis of neuroimaging data and training in the use of transcranial magnetic stimulation (TMS) as a translational clinical and research tool; (2) a research objective to identify patient-specific biomarkers of emotion dysregulation in BD and to experimentally engage these targets using TMS; (3) a team of mentors and advisors to ensure the candidate’s success, with expertise in bipolar disorder pathology and treatment (Dr. Andrew Nierenberg), advanced network analysis of neuroimaging data (Dr. Randy Buckner), clinical and research applications of TMS (Dr. Mark George and Dr. Joan Camprodon), neuromodulation of mood disorders (Dr. Darin Dougherty), emotion regulation (Dr. James Gross), task-based neuroimaging in BD (Dr. Thilo Deckersbach), and advanced statistical methods (Dr. Mark Vangel). The central hypothesis of the research proposal is that neuromodulation of patient-specific targets of emotion regulation-related neurocircuitry using TMS will enhance the capacity for emotion regulation in BD. The rationale for this proposal is that existing treatments don’t adequately address severe emotion dysregulation in BD, thus new innovative approaches are needed. This project has the potential to provide preliminary evidence for the future development of TMS as an innovative treatment strategy that can be used adjunctive to existing treatments to improve emotion regulation in BD. Specific aims proposed are: 1) to identify patient-specific pathophysiological markers of implicit and explicit emotion dysregulation in BD; 2) to determine the effect of TMS on emotion regulation circuit dynamics in BD; and 3) to determine the effect of TMS on emotion regulation behavioral responses in BD. The approach is innovative in that it uses a patient- specific, precision medicine approach with combined TMS-fMRI to target and probe emotion dysregulation at the level of neurocircuitry. The proposed research is significant, because it is has the potential to advance our understanding of the pathophysiology of emotion dysregulation in BD and will provide crucial pilot data towards testing the efficacy of TMS for improving emotion dysregulation in BD patients. Overall, the candidate will use this project and its associated training to transition and expand this work into an independent program of research developing neuroscience-informed interventions for bipolar mood disorders.

项目总结/文摘