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An fMRI Investigation of the Neural Pathways Behind Emotional Acceptance

情绪接受背后神经通路的功能磁共振成像研究

基本信息

批准号：
8063895
负责人：
Kristen K Ellard
金额：
$ 0.39万
依托单位：
BOSTON UNIVERSITY (CHARLES RIVER CAMPUS)
依托单位国家：
美国
项目类别：
财政年份：
2009
资助国家：
美国
起止时间：
2009-05-08 至 2012-06-30
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/8063895
关键词：
Affect Aftercare American Amygdaloid structure Anterior Anxiety Disorders Clinical Cognitive Therapy Communication Country Development Disease Educational Intervention Emotional Emotional disorder Emotions Etiology Fellowship Foundations Functional Magnetic Resonance Imaging Future Generalized Anxiety Disorder Goals Health Hippocampus (Brain)Hour Image Individual Insula of Reil Intervention Investigation Menin Mood Disorders Neural Pathways Neurosciences Participant Patient Self-Report Patients Pattern Population Prefrontal Cortex Procedures Process Regulation Relative (related person)Research Route Sampling Structure Techniques Training Treatment Protocols Work affective neuroscience attenuation base career cingulate cortex cost disorder later incidence prevention emotion regulation emotional experience emotional stimulus experience improved interest neuromechanism psychosocial relating to nervous system research study response skills skills training successful intervention tool

项目摘要

DESCRIPTION (provided by applicant): The specific goals of the research study proposed for this fellowship are to use functional magnetic resonance imaging (fMRI) to gain a better understanding of the neural mechanisms underlying emotional acceptance as an emotion regulation technique, while simultaneously providing invaluable training in the use of fMRI as a research tool. Through the use of fMRI, the proposed study will examine patterns of activation and de-activation in neural structures while engaging in emotional acceptance as an emotion regulation strategy in a clinical sample. Specifically, this study will examine the following: 1) activation of specific regions of interest (ROIs; amygdala, insula, hippocampus, anterior cingulate cortex, orbitofrontal cortex, prefrontal cortex) of an "Accept" condition relative to "Attend" and "Suppress" conditions during a negative emotion induction; 2) differences in patterns of activation in these two conditions between those who have and have not undergone skills training in emotional acceptance as an emotion regulation strategy; and 3) the relationship between changes in patterns of activation and self-reported changes in the subjective experience of negative emotion. Skills training in emotional acceptance skills will be based upon procedures currently used in the Unified Protocol for the Treatment of Emotional Disorders (Barlow, Allen, Ellard & Fairholme, 2008), and will be carried out over five, 1-hour sessions prior to a post-treatment imaging session. The broader aim of this study is to bridge affective neuroscience and emotion regulation research to investigate the neural mechanisms associated with emotional acceptance to gain a better understanding of the ultimate utility of this approach as applied to the treatment of anxiety and mood disorders. PUBLIC HEALTH RELEVANCE: Anxiety and mood disorders disrupt the lives of millions of Americans, with lifetime prevelance rates for anxiety disorders estimated at 29% of the population, and mood disorders at 21% (Kessler et al., 2005). Further, anxiety disorders alone represent a cost to this country of over $42 billion annually (Greenberg et al., 1999). It is hoped that by understanding how emotion regulation strategies such as emotional acceptance affect communication between cortical and limbic structures during emotional processing, we might gain a better understanding not only of the etiology of anxiety and mood disorders at a neural level, but also of how to effectively ameliorate or correct maladaptive emotional processing in these disorders using a unified, transdiagnostic approach. The experience of conducting this study will provide a strong foundation from which to pursue long-term career goals - to bridge affective neuroscience and emotion regulation research to improve psychosocial treatments for anxiety and mood disorders.

描述（由申请人提供）：本研究的具体目标是使用功能性磁共振成像（fMRI）来更好地了解情绪接受作为情绪调节技术的神经机制，同时提供使用fMRI作为研究工具的宝贵培训。通过使用功能磁共振成像，拟议的研究将检查模式的激活和去激活的神经结构，而从事情绪接受作为一种情绪调节策略在临床样本。具体而言，本研究将检查以下内容：1）特定感兴趣区域的激活（ROI;杏仁核、杏仁核、海马、前扣带皮层、眶额皮层、前额叶皮层）;（2）在这两种情况下，接受和未接受作为情绪调节策略的情绪接受技能训练的受试者的激活模式存在差异; 3）激活模式的变化与自我报告的消极情绪主观体验变化之间的关系。情绪接受技能的技能培训将基于情绪障碍治疗统一方案（Barlow、艾伦、Ellard和Fairholme，2008）中目前使用的程序，并将在治疗后成像会议之前进行5次1小时的会议。本研究的更广泛的目的是弥合情感神经科学和情绪调节研究，以调查与情绪接受相关的神经机制，以更好地了解这种方法应用于治疗焦虑和情绪障碍的最终效用。公共卫生关系：焦虑和情绪障碍扰乱了数百万美国人的生活，焦虑症的终生患病率估计为29%，情绪障碍为21%（Kessler等人，2005年）。此外，仅焦虑症就代表了这个国家每年超过420亿美元的成本（Greenberg等人，1999年）。希望通过了解情绪调节策略（如情绪接受）如何影响情绪处理过程中皮层和边缘结构之间的沟通，我们不仅可以更好地了解焦虑和情绪障碍在神经水平上的病因，而且可以更好地了解如何使用统一的transdiagnosis方法有效地改善或纠正这些障碍中的适应不良情绪处理。进行这项研究的经验将为追求长期职业目标提供坚实的基础--架起情感神经科学和情绪调节研究的桥梁，以改善焦虑和情绪障碍的心理社会治疗。