Airway epithelial IAPs and their interaction with Zn ions

气道上皮 IAP 及其与锌离子的相互作用

• 批准号: nhmrc : 519206
• 负责人: Dr Chiara Murgia
• 金额: $ 17.39万
• 依托单位: The University of Adelaide
• 依托单位国家: 澳大利亚
• 项目类别: NHMRC Project Grants
• 财政年份: 2008
• 资助国家: 澳大利亚
• 起止时间: 2008-01-01 至 2011-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/airway-epithelial-iaps-zn-ions/94694
• 关键词: Airway; epithelial; IAPs; their; interaction

The air we breathe contains a variety of harmful substances. Damage to the lining involves death of the ciliated cells that line the airways. We have shown that zinc protects these cells from premature death. This application focuses on a family of proteins called IAPs which bind zinc and regulate cell death in other tissues. This project focusses on how the IAPs and Zn may act together to mainitain healthy airways and how abnormalities of these may occur in people with asthma.

我们呼吸的空气中含有多种有害物质。对衬里的损害涉及到排列在气道上的纤毛细胞的死亡。我们已经证明，锌可以保护这些细胞免于过早死亡。该应用程序集中在一个名为IAP的蛋白质家族上，该蛋白质家族结合锌并调节其他组织中的细胞死亡。该项目的重点是IAP和锌如何共同作用，以维持健康的气道，以及这些异常如何发生在哮喘患者中。