Role for zinc and ZIP2 in the action of nitric oxide and in vascular protection against cigarette smoke and cardiovascular disease

锌和 ZIP2 在一氧化氮作用以及针对香烟烟雾和心血管疾病的血管保护中的作用

• 批准号: nhmrc : GNT1138917
• 负责人: Dr Chiara Murgia
• 金额: $ 68.59万
• 依托单位国家: 澳大利亚
• 项目类别: Project Grants
• 财政年份: 2018
• 资助国家: 澳大利亚
• 起止时间: 2018-01-01 至 无数据
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/role-zinc-zip2-cardiovascular-disease/1348193
• 关键词: Role; zinc; ZIP2; action; nitric

The NO/cGMP signalling pathway, which is central to cardiovascular physiology and protection against disease, is only fully effective when there are adequate levels of zinc in the vascular endothelium. This is especially important where zinc stores are depleted (elderly, smokers, diabetics and kidney disease). There is an urgent clinical need to implement strategies to monitor vascular Zn status. This application will explore the underlying science and translate these to the clinic.

NO/cGMP信号通路是心血管生理学和预防疾病的核心，只有当血管内皮中有足够的锌水平时才完全有效。这在锌储备耗尽的情况下（老年人，吸烟者，糖尿病患者和肾脏疾病）尤为重要。临床上迫切需要实施监测血管锌状态的策略。该应用程序将探索潜在的科学，并将其转化为临床。