Dermatology Research Training Program

皮肤科研究培训计划

• 批准号: 10618235
• 负责人: Richard C Wang
• 金额: $ 25.16万
• 依托单位: UT SOUTHWESTERN MEDICAL CENTER
• 依托单位国家: 美国
• 财政年份: 2014
• 资助国家: 美国
• 起止时间: 2014-07-01 至 2025-05-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10618235
• 关键词: Dermatology; Research Training; Training Programs

ABSTRACT: An over-arching goal of the Department of Dermatology at The University of Texas Southwestern Medical Center is to produce scientific leaders in skin biology and skin disease. To sustain this goal, we seek to renew our T32 Dermatology Research Training Program, which primarily recruits MD/PhD or MD candidates from dermatology residency applicants as early as the residency match. The program’s success can be measured by our graduates’ achievements in acquiring federal grants as principal investigators (over 60% of graduates to date) and leadership positions in academia and industry. These accomplishments validate current policies: (1) selecting candidates with proven scientific achievements and strong potential for independent investigation; (2) continuing a physician-scientist track that trains 2 yrs. in clinical dermatology and then 2 yrs. in research (historically fundamental and/or translational, but with recent expansion into clinical); and (3) preceptorship under outstanding faculty from our Graduate School of Biosciences. The program will continue to be administered: by the same director and 2 co- directors (a senior one and a junior one who is a program alumnus) plus a new (internationally renowned) PhD scientist, by a coordinator, and by 3 advisors who hold Dean-ship positions at Southwestern. We gathered 38 potential preceptors (including a Nobel laureate and 9 members of the National Academy of Science), all of whom have received NIH R01 grants and are effective mentors and meaningful interactors with dermatology personnel. In the aggregate, our preceptors’ publications rate a high mean H-index of 64. For the next funding cycle, we have already recruited 6 outstanding post-doc trainees. The program was given exceptional reviews by Dennis Roop PhD in 2018 and by Alice Pentland MD in 2019, with Dr. Pentland judging the program in the context of comments from the Study Section.

摘要： 德克萨斯大学西南分校皮肤科的总体目标 医学中心是培养皮肤生物学和皮肤病的科学领先者。为了维持这一目标，我们 寻求续订我们的T32皮肤病研究培训计划，该计划主要招聘医学博士或博士或 MD考生最早从皮肤科住院医师申请者中匹配住院医师。该计划的 成功与否可以用我们的毕业生作为校长获得联邦助学金的成绩来衡量 研究人员(到目前为止超过60%的毕业生)以及学术界和工业界的领导职位。这些 成就验证了现行政策：(1)选择具有已证实的科学成就的候选人 和强大的独立调查潜力；(2)继续培养2名医生-科学家的轨道 几年前。在临床皮肤科，然后两年。在研究中(历史上的基础和/或翻译，但 最近扩展到临床)；和(3)在我们研究生优秀教员的指导下 生物科学学院。该计划将继续由同一主管和2名联合主管负责管理。 董事(一名高级和一名初级计划校友)外加一名新的(国际) 著名)博士科学家，由一名协调员和3名担任院长职位的顾问在 西南部。我们召集了38名潜在的倡导者(包括一名诺贝尔奖获得者和9名 美国国家科学院)，所有人都获得了NIH R01拨款，是有效的导师 并与皮肤科人员进行有意义的互动。总体而言，我们的训诫出版物 的平均H指数很高。对于下一个资金周期，我们已经招募了6名优秀员工 博士后实习生。2018年，丹尼斯·鲁普博士对该项目给予了特殊评价，并 艾丽斯·彭特兰博士在2019年获得医学博士学位，彭特兰博士根据 学习组。

项目成果

Ubiquitin-like conjugation by bacterial cGAS enhances anti-phage defence.

• DOI: 10.1038/s41586-023-05862-7
• 发表时间: 2023-04
• 期刊: Nature
• 影响因子: 64.8
• 作者: Jenson JM;Li T;Du F;Ea CK;Chen ZJ
• 通讯作者: Chen ZJ

Digoxin Plus Trametinib Therapy Achieves Disease Control in BRAF Wild-Type Metastatic Melanoma Patients.

• DOI: 10.1016/j.neo.2017.01.010
• 发表时间: 2017-04
• 期刊: Neoplasia (New York, N.Y.)
• 作者: Frankel AE;Eskiocak U;Gill JG;Yuan S;Ramesh V;Froehlich TW;Ahn C;Morrison SJ
• 通讯作者: Morrison SJ

cGAS goes viral: A conserved immune defense system from bacteria to humans.

• DOI: 10.1016/j.molcel.2023.12.005
• 发表时间: 2024-01
• 期刊: Molecular cell
• 影响因子: 16
• 作者: Justin Jenson;Zhijian J. Chen

9-O-acetyl sialic acid levels identify committed progenitors of plasmacytoid dendritic cells.

9-O-乙酰唾液酸水平可识别浆细胞样树突状细胞的定型祖细胞。

• DOI: 10.1093/glycob/cwz062
• 发表时间: 2019
• 期刊: Glycobiology
• 影响因子: 4.3
• 作者: Netravali,IlkaA;Cariappa,Annaiah;Yates,Kathleen;Haining,WNicholas;Bertocchi,Alice;Allard-Chamard,Hugues;Rosenberg,Ian;Pillai,Shiv
• 通讯作者: Pillai,Shiv

Loss of glucose 6-phosphate dehydrogenase function increases oxidative stress and glutaminolysis in metastasizing melanoma cells.

• DOI: 10.1073/pnas.2120617119
• 发表时间: 2022-02-08
• 期刊: Proceedings of the National Academy of Sciences of the United States of America
• 影响因子: 11.1
• 作者: Aurora AB;Khivansara V;Leach A;Gill JG;Martin-Sandoval M;Yang C;Kasitinon SY;Bezwada D;Tasdogan A;Gu W;Mathews TP;Zhao Z;DeBerardinis RJ;Morrison SJ
• 通讯作者: Morrison SJ