Excitation and Inhibition in Neural Circuits of the Visual Cortex

视觉皮层神经回路的兴奋和抑制

• 批准号: 10617766
• 负责人: Hillel Adesnik
• 金额: $ 49.03万
• 依托单位: UNIVERSITY OF CALIFORNIA BERKELEY
• 依托单位国家: 美国
• 财政年份: 2013
• 资助国家: 美国
• 起止时间: 2013-09-01 至 2024-05-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10617766
• 关键词: Area; Behavior; Brain; Cells; Cerebral cortex; Data; Dependence; Detection; Disinhibition; Electrophysiology (science); Equilibrium; Exhibits; Head; Image; Interneurons; Knowledge; Measures; Mediating; Modeling; Mus; Neurons; Parvalbumins; Pattern; Perception; Play; Process; Pyramidal Cells; Research Personnel; Role; Sensory; Somatostatin; Stimulus; Synapses; Testing; Texture; V1 neuron; Vasoactive Intestinal Peptide; Vision; Visual; Visual Cortex; Visual Fields; Whole-Cell Recordings; area striata; awake; cell type; cellular imaging; experimental study; extracellular; flexibility; insight; nervous system disorder; neural; neural circuit; optogenetics; receptive field; response; segregation; two-photon; visual stimulus

PROJECT SUMMARY Neural circuits of the primary visual cortex (V1) are critical for generating perceptions of our external world. In V1, most neurons exhibit potent modulation by stimuli that are outside their receptive fields, a process termed ‘surround modulation’. Importantly, the magnitude and sign of surround modulation depend on the orientation and contrast of the center and surround – leading to the notion that flexible surround modulation contributes to scene segmentation, salience detection, contour integration, and figure/ground segregation. The specific neural circuits in V1 that explain the feature dependence of surround modulation are largely unknown. By combining intracellular and extracellular electrophysiology, two photon imaging, and optogenetics in awake mice, we aim to reveal the inhibitory circuits in V1 that can account for these fundamental features of V1 computation. Specifically, we will test the hypothesis that a competitive inhibitory interaction between two types of V1 GABAergic interneurons (‘SST’ and ‘VIP’) cells, provides a circuit and synaptic basis for the feature dependence of surround modulation. We will image the visual responses of these two subtypes, then manipulate them optogenetically while recording neural activity extracellularly, or synaptic currents intracellularly, to test whether their visual responses and network impact are consistent with key roles in the orientation and contrast dependence of surround modulation. These experiments will provide critical new insight into how cortical inhibitory circuits mediate key aspects of sensory perception.

项目总结

项目成果

Synaptic Mechanisms of Feature Coding in the Visual Cortex of Awake Mice.

• DOI: 10.1016/j.neuron.2017.08.014
• 发表时间: 2017-08-30
• 期刊: Neuron
• 影响因子: 16.2
• 作者: Adesnik H

Precision multidimensional neural population code recovered from single intracellular recordings.

• DOI: 10.1038/s41598-020-72936-1
• 发表时间: 2020-09-29
• 期刊: Scientific reports
• 影响因子: 4.6
• 作者: Johnson JK;Geng S;Hoffman MW;Adesnik H;Wessel R
• 通讯作者: Wessel R

Probing neural codes with two-photon holographic optogenetics.

• DOI: 10.1038/s41593-021-00902-9
• 发表时间: 2021-10
• 期刊: NATURE NEUROSCIENCE
• 影响因子: 25
• 作者: Adesnik, Hillel;Abdeladim, Lamiae
• 通讯作者: Abdeladim, Lamiae

A neural circuit for gamma-band coherence across the retinotopic map in mouse visual cortex.

• DOI: 10.7554/elife.28569
• 发表时间: 2018-02-26
• 期刊: eLife
• 影响因子: 7.7
• 作者: Hakim R;Shamardani K;Adesnik H
• 通讯作者: Adesnik H

Synthesis of a comprehensive population code for contextual features in the awake sensory cortex.

• DOI: 10.7554/elife.62687
• 发表时间: 2021-11-01
• 期刊: eLife
• 影响因子: 7.7
• 作者: Lyall EH;Mossing DP;Pluta SR;Chu YW;Dudai A;Adesnik H
• 通讯作者: Adesnik H