University of Florida Health Cancer Center Support Grant

总体：摘要 表彰在促进跨学科研究、包容性劳动力发展、 社区参与，并有能力提高其对集水区（CA）的影响，佛罗里达大学 健康癌症中心（UFHCC）寻求NCI指定。UFHCC是支持癌症的基质中心 在所有6 UF健康科学学院（牙科，医学，护理， 药学，公共卫生与健康教育，兽医）和其他5个UF学院（农业， 工程、健康与人类绩效、新闻与传播以及文科与理科）。 合作研究由147名成员在3个UFHCC科学计划中进行： 肿瘤发生，癌症治疗和宿主反应，癌症控制和人口科学。的 UFHCC通过以下方式为其成员提供最先进的技术和研究专业知识： 共享资源：生物统计学和定量科学，流式细胞术和共聚焦显微镜，以及下一步 世代排序。UFHCC CA包括佛罗里达中北部的23个相邻县， ~17,500平方米，大约是新英格兰南部的大小。大多数县（16个）是农村，每个县都是 被列为医疗服务不足的地区。加州人口为220万，其中包括黑人 (16%），西班牙裔（10%），在佛罗里达≥65岁的居民中所占比例最高（23%）。通过社区 UFHCC支持努力提高健康素养，预防，筛查和研究参与。 UFHCC临床研究办公室协调UF的所有癌症相关临床研究，其中包括 全国临床试验网络。IIT通过疾病现场小组与IIT智囊团促进， 临床医生与基础和人口科学家的合作。UFHCC转化为临床的创新包括 靶向治疗、新型免疫治疗、微生物组的治疗性调节以及 与患者沟通。UFHCC发展基金种子早期研究，支持招募 新的教师，并建立跨学科的团队。UFHCC提供包容性的研究职业提升计划 across横过the learner学习者spectrum光谱.自2016年以来，UFHCC招募了58名新成员（45名外部成员，39名早期成员） (45妇女占17%，城市登记处占17%）。同行评审资金从2016年的2100万美元增加到2021年的3260万美元/年（增长55%）; NCI 960万美元至1320万美元（增长37%）。所有干预性试验的应计费用从2016年的515项增加到2021年的1，748项（增加 3.4倍）。未来5年每年3200万美元的预算和44，000平方英尺的新研究空间的机构支持 将使UFHCC得以扩张。新的UFHCC战略计划，Momentum 2027，有4个支柱：1）行为 跨学科研究（RNA生物学，微生物组）; 2）将UFHCC发现转化为试验（免疫疗法， 小分子，癌症通讯）; 3）解决癌症负担（癌症和衰老，癌症健康 差异）;和，4）培训准备和多样化的癌症研究队伍，包括领导力的发展。 UFHCC准备对集水区、佛罗里达及其他地区的癌症负担产生重大影响。

OVERALL: ABSTRACT In recognition of achievements in fostering transdisciplinary research, inclusive workforce development, community engagement, and ability to enhance its impact on the catchment area (CA), the University of Florida Health Cancer Center (UFHCC) seeks NCI-Designation. UFHCC is a matrix center that supports cancer research and career enhancement across all 6 UF health sciences colleges (Dentistry, Medicine, Nursing, Pharmacy, Public Health & Health Professions, and Veterinary Med) and 5 other UF colleges (Agriculture, Engineering, Health & Human Performance, Journalism & Communications, and Liberal Arts & Sciences). Collaborative research is conducted by 147 members across 3 UFHCC scientific programs: Mechanisms of Oncogenesis, Cancer Therapeutics and Host Response, and Cancer Control and Population Sciences. The UFHCC provides access to state-of-the-art technologies and research expertise for its members through 3 shared resources: Biostatistics and Quantitative Sciences, Flow Cytometry and Confocal Microscopy, and Next Generation Sequencing. The UFHCC CA includes 23 contiguous counties in North Central Florida spanning ~17,500 mi2, about the size of Southern New England. Most of the counties (16) are rural and every county is classified as a Medically Underserved Area. The CA population is 2.2M and includes people who are Black (16%), Hispanic (10%), and has the highest fraction (23%) of residents ≥65 years in Florida. Through community outreach, UFHCC supports efforts to increase health literacy, prevention, screening, and research engagement. The UFHCC Clinical Research Office coordinates all cancer-relevant clinical research at UF, which includes a state-wide clinical trial network. IITs are facilitated through disease site groups with an IIT Think Tank that fosters clinician collaboration with basic and population scientists. UFHCC innovations translated to the clinic include targeted therapies, novel immunotherapies, therapeutic modulation of the microbiome, and new strategies to communicate with patients. UFHCC Developmental Funds seed early-stage research, support recruitment of new faculty, and build transdisciplinary teams. UFHCC offers inclusive research career enhancement programs across the learner spectrum. Since 2016, the UFHCC recruited 58 new members (45 external, 39 early-stage) (45% women, 17% URM). Peer-reviewed funding increased from $21M in 2016 to $32.6M/yr in 2021 (up 55%); NCI $9.6M to $13.2M (up 37%). Accruals to all interventional trials rose from 515 in 2016 to 1,748 in 2021 (up 3.4-fold). Institutional support of a $32M/year budget over the next 5 years and 44,000ft2 of new research space will allow UFHCC to expand. The new UFHCC strategic plan, Momentum 2027, has 4 pillars: 1) conduct transdisciplinary research (RNA biology, microbiome); 2) translate UFHCC discoveries to trials (immunotherapy, small molecules, cancer communication); 3) address cancer burden (cancer and aging, cancer health disparities); and, 4) train a prepared and diverse cancer research workforce, including leadership development. UFHCC is poised to make a major impact on the cancer burden of the catchment area, Florida, and beyond.