Administrative Core (Core A)

心力衰竭进展是一个复杂的生物过程，是由适应不良引起的 心肌对损伤的反应，再加上成人心脏不能取代丢失或受损的心脏 心肌细胞。可想而知，确定调节这两个看似 不相关的过程将深刻影响预防甚至逆转心脏的治疗策略 故障进展。提议的财团成员和其他人的许多意见都支持 新生哺乳动物心脏的内源性增殖能力在 出生后早期的生命作为心肌细胞从肥大到肥大生长的转换发生。 拟议财团的成员和其他成员此前也证明了这种机制 与免疫反应的激活有关，可能在心肌细胞肥大、死亡、 治愈甚至刺激新的心肌细胞生成。目前的提案汇集了 几个在心肌重塑、再生和免疫学方面具有显著专长的小组 确定免疫反应信号在心脏生长调节中的作用的总体目标是， 治愈和再生。事实上，在过去的几年里，免疫反应一直占据着中心舞台 作为心脏健康老化和损伤后愈合的主要决定因素，以及 当慢性病受到不适当的监管时，其决定因素就会出现。因此，该计划将 调查科学研究的前沿和新兴领域，涉及科学研究的交叉领域 免疫系统和心肌。拟议方案的行政核心(核心A) 项目将为4个项目以及另外两个项目提供关键的行政和后勤服务 核心、核心B和核心C通过我们四个项目中提出的高度相关的一系列实验 项目，并得到行政核心(核心A)、免疫学和 生理学核心(核心B和C)，我们的目标是回答对理解 免疫在心脏动态平衡和病理调节中的作用。总而言之，这些研究将 检验一种改变范式的假设，即免疫系统是心脏生长的关键调节因素 并进行修复。行政核心将设在德克萨斯大学西南医学中心， 心脏病科。核心A将由Hesham Sadek博士领导，并将负责提供PI 以及拥有实现项目目标所需的行政和后勤支助的关键人员。 核心A将提供研究行政支持、财政和知识产权支持、促进 沟通，并为整个项目提供统计咨询。因此，核心A将 作为计划项目的运营经理发挥至关重要的作用。

Heart failure progression is a complex biological process that is precipitated by the maladaptive myocardial response to injury, compounded by failure of the adult heart to replace lost or damaged cardiomyocytes. Conceivably, identifying common pathways that regulate these two seemingly unrelated processes would profoundly impact therapeutic strategies to prevent, and even reverse heart failure progression. Numerous observations by members of the proposed consortium and others support the notion that the endogenous capacity of the neonatal mammalian heart to proliferate fades in the early postnatal life as a switch from hyperplastic to hypertrophic growth of cardiomyocytes takes place. Members of the proposed consortium and others have also previously demonstrated that mechanisms linked to activation of the immune response may play a role in cardiomyocyte hypertrophy, death, healing and even stimulation of new cardiomyocyte generation. The current proposal brings together several groups with significant expertise in myocardial remodeling, regeneration and immunology with the overall goal of determining the role of immune response signaling in regulation of cardiac growth, healing and regeneration. Indeed, the immune response has taken center stage in the past several years as a primary determinant of both healthy cardiac aging and healing after injury, as well as a determinant of chronic disease states when it is inappropriately regulated. Thus, this Program will investigate a frontier and emerging area of scientific investigation involving the intersection between the immune system and the myocardium. The Administrative Core (Core A) of the proposed Program Project will provide critical administrative and logistical services of the 4 Projects as well as the two other cores, Core B and Core C. Through the highly interrelated series of experiments proposed in our four Projects, and supported by the activities of an Administrative Core (Core A), Immunology and Physiology Cores (Cores B, and C), we aim to answer questions that are crucial for understanding the role of immunity in the regulation of cardiac homeostasis and pathology. Together, these studies will test a paradigm changing hypothesis that the immune system is a critical regulator of cardiac growth and repair. The Administrative Core will be housed at University of Texas Southwestern Medical Center, Division of Cardiology. Core A will be led by Dr. Hesham Sadek and will be tasked with providing PIs and key personnel with the administrative and logistic support needed to achieve the goals of the project. Core A will provide research administrative support, fiscal and intellectual property support, facilitate communications, and provide statistical consultation for the entire Program Project. As such Core A will play a vital role as the operational manager of the Program Project.