Administrative Core (Core A)

行政核心（核心A）

• 批准号: 10625949
• 负责人: Hesham Sadek
• 金额: $ 10.66万
• 依托单位: UT SOUTHWESTERN MEDICAL CENTER
• 依托单位国家: 美国
• 财政年份: 2023
• 资助国家: 美国
• 起止时间: 2023-04-05 至 2028-03-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10625949
• 关键词: Adult; Aging; Agreement; Animal Experiments; Area; Bioinformatics; Biological Process; Budgets; Cardiac; Cardiac Myocytes; Cardiology; Cells; Cessation of life; Child; Chronic Disease; Communication; Communities; Complex; Consultations; Data Analyses; Experimental Designs; Failure; Generations; Goals; Growth; Heart; Heart failure; Homeostasis; Human Resources; Hyperplasia; Hypertrophy; Immune response; Immune system; Immunity; Immunology; Individual; Injury; Institution; Intellectual Property; Investigation; Knowledge; Laboratories; Life; Link; Logistics; Manuscripts; Mediating; Medical center; Myocardial; Myocardium; National Heart, Lung, and Blood Institute; Natural regeneration; Neonatal; Online Systems; Participant; Pathology; Pathway interactions; Physiology; Play; Postdoctoral Fellow; Preparation; Process; Progress Reports; Proliferating; Reagent; Regulation; Research; Research Personnel; Resources; Role; Schedule; Series; Services; Signal Transduction; Students; Testing; Texas; Therapeutic; Tissues; Training; Universities; Ventricular Remodeling; data communication; data sharing; experimental study; frontier; healing; immune activation; meetings; member; operation; postnatal; prevent; programs; recruit; repaired; response to injury; web site

Heart failure progression is a complex biological process that is precipitated by the maladaptive myocardial response to injury, compounded by failure of the adult heart to replace lost or damaged cardiomyocytes. Conceivably, identifying common pathways that regulate these two seemingly unrelated processes would profoundly impact therapeutic strategies to prevent, and even reverse heart failure progression. Numerous observations by members of the proposed consortium and others support the notion that the endogenous capacity of the neonatal mammalian heart to proliferate fades in the early postnatal life as a switch from hyperplastic to hypertrophic growth of cardiomyocytes takes place. Members of the proposed consortium and others have also previously demonstrated that mechanisms linked to activation of the immune response may play a role in cardiomyocyte hypertrophy, death, healing and even stimulation of new cardiomyocyte generation. The current proposal brings together several groups with significant expertise in myocardial remodeling, regeneration and immunology with the overall goal of determining the role of immune response signaling in regulation of cardiac growth, healing and regeneration. Indeed, the immune response has taken center stage in the past several years as a primary determinant of both healthy cardiac aging and healing after injury, as well as a determinant of chronic disease states when it is inappropriately regulated. Thus, this Program will investigate a frontier and emerging area of scientific investigation involving the intersection between the immune system and the myocardium. The Administrative Core (Core A) of the proposed Program Project will provide critical administrative and logistical services of the 4 Projects as well as the two other cores, Core B and Core C. Through the highly interrelated series of experiments proposed in our four Projects, and supported by the activities of an Administrative Core (Core A), Immunology and Physiology Cores (Cores B, and C), we aim to answer questions that are crucial for understanding the role of immunity in the regulation of cardiac homeostasis and pathology. Together, these studies will test a paradigm changing hypothesis that the immune system is a critical regulator of cardiac growth and repair. The Administrative Core will be housed at University of Texas Southwestern Medical Center, Division of Cardiology. Core A will be led by Dr. Hesham Sadek and will be tasked with providing PIs and key personnel with the administrative and logistic support needed to achieve the goals of the project. Core A will provide research administrative support, fiscal and intellectual property support, facilitate communications, and provide statistical consultation for the entire Program Project. As such Core A will play a vital role as the operational manager of the Program Project.

心力衰竭进展是一个复杂的生物学过程， 心肌对损伤的反应，再加上成年心脏无法替代丢失或受损的心脏， 心肌细胞可以想象，识别调节这两种似乎 不相关的过程将深刻影响治疗策略，以防止，甚至逆转心脏 故障进展拟议的联合体成员和其他人的许多意见支持 新生哺乳动物心脏的内源性增殖能力在新生儿期逐渐减弱， 出生后早期，心肌细胞从增生性生长转变为肥大性生长。 拟议的联合体的成员和其他人以前也证明， 与免疫应答的激活相关的可能在心肌细胞肥大，死亡， 愈合甚至刺激新心肌细胞的产生。目前的提案汇集了 几个在心肌重塑、再生和免疫学方面具有重要专业知识的小组， 总体目标是确定免疫应答信号传导在调节心脏生长中的作用， 愈合和再生。事实上，在过去的几年里，免疫反应已经成为中心舞台。 作为健康心脏老化和损伤后愈合的主要决定因素， 慢性疾病状态的决定因素，当它是不适当的调节。因此，该方案将 调查一个前沿和新兴的科学调查领域，涉及 免疫系统和心肌。核心计划（Core A） 项目将为4个项目以及另外两个项目提供关键的行政和后勤服务。 核心、核心B和核心C。通过我们在四个实验中提出的高度相关的一系列实验， 项目，并得到行政核心（核心A），免疫学和 生理学核心（核心B和C），我们的目标是回答对于理解 免疫在调节心脏稳态和病理中的作用。这些研究将 测试一个改变范式的假设，即免疫系统是心脏生长的关键调节器 和修复。行政核心将设在得克萨斯大学西南医学中心， 心脏科。核心A将由Hesham Sadek博士领导，负责提供PI 以及关键人员，提供实现项目目标所需的行政和后勤支持。 核心A将提供研究行政支持、财政和知识产权支持， 通信，并为整个计划项目提供统计咨询。核心A将 作为计划项目的运营经理，发挥重要作用。