Administrative Core (Core A)

行政核心（核心A）

• 批准号: 10625949
• 负责人: Hesham Sadek
• 金额: $ 10.66万
• 依托单位: UT SOUTHWESTERN MEDICAL CENTER
• 依托单位国家: 美国
• 财政年份: 2023
• 资助国家: 美国
• 起止时间: 2023-04-05 至 2028-03-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10625949
• 关键词: Adult; Aging; Agreement; Animal Experiments; Area; Bioinformatics; Biological Process; Budgets; Cardiac; Cardiac Myocytes; Cardiology; Cells; Cessation of life; Child; Chronic Disease; Communication; Communities; Complex; Consultations; Data Analyses; Experimental Designs; Failure; Generations; Goals; Growth; Heart; Heart failure; Homeostasis; Human Resources; Hyperplasia; Hypertrophy; Immune response; Immune system; Immunity; Immunology; Individual; Injury; Institution; Intellectual Property; Investigation; Knowledge; Laboratories; Life; Link; Logistics; Manuscripts; Mediating; Medical center; Myocardial; Myocardium; National Heart, Lung, and Blood Institute; Natural regeneration; Neonatal; Online Systems; Participant; Pathology; Pathway interactions; Physiology; Play; Postdoctoral Fellow; Preparation; Process; Progress Reports; Proliferating; Reagent; Regulation; Research; Research Personnel; Resources; Role; Schedule; Series; Services; Signal Transduction; Students; Testing; Texas; Therapeutic; Tissues; Training; Universities; Ventricular Remodeling; data communication; data sharing; experimental study; frontier; healing; immune activation; meetings; member; operation; postnatal; prevent; programs; recruit; repaired; response to injury; web site

Heart failure progression is a complex biological process that is precipitated by the maladaptive myocardial response to injury, compounded by failure of the adult heart to replace lost or damaged cardiomyocytes. Conceivably, identifying common pathways that regulate these two seemingly unrelated processes would profoundly impact therapeutic strategies to prevent, and even reverse heart failure progression. Numerous observations by members of the proposed consortium and others support the notion that the endogenous capacity of the neonatal mammalian heart to proliferate fades in the early postnatal life as a switch from hyperplastic to hypertrophic growth of cardiomyocytes takes place. Members of the proposed consortium and others have also previously demonstrated that mechanisms linked to activation of the immune response may play a role in cardiomyocyte hypertrophy, death, healing and even stimulation of new cardiomyocyte generation. The current proposal brings together several groups with significant expertise in myocardial remodeling, regeneration and immunology with the overall goal of determining the role of immune response signaling in regulation of cardiac growth, healing and regeneration. Indeed, the immune response has taken center stage in the past several years as a primary determinant of both healthy cardiac aging and healing after injury, as well as a determinant of chronic disease states when it is inappropriately regulated. Thus, this Program will investigate a frontier and emerging area of scientific investigation involving the intersection between the immune system and the myocardium. The Administrative Core (Core A) of the proposed Program Project will provide critical administrative and logistical services of the 4 Projects as well as the two other cores, Core B and Core C. Through the highly interrelated series of experiments proposed in our four Projects, and supported by the activities of an Administrative Core (Core A), Immunology and Physiology Cores (Cores B, and C), we aim to answer questions that are crucial for understanding the role of immunity in the regulation of cardiac homeostasis and pathology. Together, these studies will test a paradigm changing hypothesis that the immune system is a critical regulator of cardiac growth and repair. The Administrative Core will be housed at University of Texas Southwestern Medical Center, Division of Cardiology. Core A will be led by Dr. Hesham Sadek and will be tasked with providing PIs and key personnel with the administrative and logistic support needed to achieve the goals of the project. Core A will provide research administrative support, fiscal and intellectual property support, facilitate communications, and provide statistical consultation for the entire Program Project. As such Core A will play a vital role as the operational manager of the Program Project.

心力衰竭进展是一个复杂的生物学过程，由不良适应性引起 心肌对损伤的反应，成人心脏无法替换失去或损坏的情况加重 心肌细胞。可以想象，确定调节这两个看似调节的通用途径 无关的过程将对预防甚至逆转心脏的治疗策略产生深远影响 故障进展。拟议财团和其他支持的成员的大量观察 新生儿哺乳动物心脏的内源能力在 从增生到心肌细胞的肥厚性生长的转变。 拟议财团和其他人的成员以前也证明了机制 与免疫反应的激活有关的可能在心肌细胞肥大，死亡， 愈合甚至刺激新的心肌细胞产生。当前的提议汇集了 几个在心肌重塑，再生和免疫学方面具有重要专业知识的小组 确定免疫反应信号传导在心脏增长调节中的作用的总体目标， 康复和再生。实际上，过去几个人的免疫反应已成为中心舞台 多年是健康心脏衰老和受伤后健康的愈合的主要决定因素，也是 慢性疾病的决定因素不适当地调节慢性疾病。因此，这个程序将 调查涉及涉及交集的科学研究领域和新兴领域 免疫系统和心肌。拟议程序的行政核心（核心A） 项目将提供4个项目以及其他两个项目的关键行政和后勤服务 核，核B和核心C通过我们四个中提出的高度相互关联的一系列实验 项目，并得到行政核心（核心A），免疫学和 生理核心（核B和C），我们旨在回答对于理解理解至关重要的问题 免疫在心脏稳态和病理调节中的作用。这些研究将在一起 测试改变免疫系统是心脏增长的关键调节剂的范式的假设 和维修。行政核心将安置在德克萨斯大学西南医学中心 心脏病学系。核心A将由Hesham Sadek博士领导，并将任务提供PIS 以及具有实现项目目标所需的行政和后勤支持的关键人员。 核心A将提供研究行政支持，财政和知识产权支持，促进 通信，并为整个计划项目提供统计咨询。这样的核心意愿 作为计划项目的运营经理发挥至关重要的作用。