Self-collimating Single Photon Emission Breast Tomography System with Three-Dimensional Sparse Position-Sensitive Detectors
具有三维稀疏位置敏感探测器的自准直单光子发射乳腺断层扫描系统
基本信息
- 批准号:10625452
- 负责人:
- 金额:$ 20.04万
- 依托单位:
- 依托单位国家:美国
- 项目类别:
- 财政年份:2022
- 资助国家:美国
- 起止时间:2022-06-01 至 2025-02-28
- 项目状态:未结题
- 来源:
- 关键词:3-DimensionalAbbreviationsAmericanAnatomyArchitectureBackBreastClinicalClinical TrialsCollimatorComputer SimulationDedicationsDetectionDevelopmentDiagnostic testsDiseaseElectroplatingEvaluationEventGamma RaysImageImaging PhantomsImaging technologyIndividualLesionLiftingLocationMalignant NeoplasmsMammographyMeasuresMechanicsMethodsMolecularMorbidity - disease rateMorphologyPathologicPathway interactionsPatientsPerformancePhotonsPlayPositioning AttributePropertyRadiation Dose UnitRadioactivityRadioisotopesRadiopharmaceuticalsReportingResolutionRodRoleSchemeScreening for cancerScreening procedureSideSignal TransductionStructureSystemTechnologyTestingTracerWomanWorkbreast cancer diagnosisbreast imagingcancer diagnosiscontrast imagingcostdesigndetection platformdetectoreffective therapyimage reconstructionimaging detectorimaging systemimprovedmalignant breast neoplasmmortalitynovelpreventprototyperesponsescreeningstemtomographytumor
项目摘要
Project Summary
Breast cancer is the most diagnosed cancer among American women and is projected to
become the most common cancer globally in 2021. To minimize the morbidity and mortality of
this disease, it is imperative to develop improved testing methods to enable more effective
treatment.
The proposed work is to develop a new Single Photon Emission Breast Tomography (SPEBT)
scanner to carry out radionuclide tracer based molecular breast imaging which has demonstrated
clear advantages in the early detection of cancer malignancy in clinical trials, because of its 1)
capability to detect pathological functional changes which take place before morphological
anatomical developments and 2) up-to pico-mole sensitivity, which stems from collecting signals
directly at the molecular level.
The SPEBT system will have a system detection efficiency of 3.5×10-2 and spatial resolution
of 2-mm, which are 50 and 2 times better than that of state-of-the-art dedicated single photon
emission molecular breast imaging cameras, respectively. The significant imaging performance
improvement will ease existing concerns on radiation dose and the inability to detect tumors of
less than 5-mm in size — issues that have prevented molecular breast imaging from playing a
much more prominent role in clinical breast cancer diagnosis and screening.
The enabling concept behind the high-performance of the SPEBT is a novel detector
architecture, a three-dimensional sparse position-sensitive detector, that achieves collimation
largely by and for itself, which is termed self-collimation. This architecture allows the SPEBT to
achieve both high-resolution and high detection efficiency. This is a critical conceptual breakaway
from the mechanical-collimator-based detector structure that single-photon emission imaging
technology relies on for years — mechanical collimator mandates an inverse interdependency
between the resolution and detection efficiency, therefore, sets a hard ceiling for overall imaging
performance. The proposed approach opens up a broad path to better imaging performance for
breast and other imaging applications.
The proposed project is to design and evaluate a SPEBT system with optimized configurations
and develop and test a proof-of-concept SPEBT prototype.
项目摘要
乳腺癌是美国女性中诊断最多的癌症,预计
成为2021年全球最常见的癌症。最大限度地减少
这种疾病,当务之急是开发改进的测试方法,使更有效的
治疗
本研究旨在开发一种新的单光子发射乳腺断层扫描仪(SPEBT)
扫描仪进行放射性核素示踪剂为基础的分子乳腺成像,这已经证明
在临床试验中早期发现癌症恶性肿瘤的明显优势,因为它的1)
检测在形态学改变之前发生的病理性功能变化的能力
解剖学的发展和2)高达皮摩尔的灵敏度,这源于收集信号
直接在分子水平上。
SPEBT系统将具有3.5×10-2的系统探测效率和空间分辨率
的2毫米,这是50和2倍优于国家的最先进的专用单光子
发射分子乳腺成像相机分别。显着的成像性能
这一改进将缓解目前对辐射剂量和无法检测肿瘤的担忧。
小于5毫米的尺寸--这些问题阻碍了分子乳腺成像在乳腺癌中发挥作用,
在临床乳腺癌诊断和筛查中的作用更加突出。
SPEBT高性能背后的启用概念是一种新型探测器
架构,一个三维稀疏的位置敏感探测器,实现准直
这被称为自准直。该架构允许SPEBT
实现高分辨率和高检测效率。这是一个关键的概念突破
从基于机械准直器的探测器结构中
技术依赖多年-机械准直器要求反向相互依赖
因此,在分辨率和探测效率之间,为整体成像设置了一个硬上限
性能所提出的方法为更好的成像性能开辟了广阔的道路,
乳房和其他成像应用。
本计画旨在设计与评估一个具有最佳组态的SPEBT系统
并开发和测试概念验证SPEBT原型。
项目成果
期刊论文数量(0)
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会议论文数量(0)
专利数量(0)
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{{ truncateString('RUTAO YAO', 18)}}的其他基金
Self-collimating Single Photon Emission Breast Tomography System with Three-Dimensional Sparse Position-Sensitive Detectors
具有三维稀疏位置敏感探测器的自准直单光子发射乳腺断层扫描系统
- 批准号:
10432218 - 财政年份:2022
- 资助金额:
$ 20.04万 - 项目类别:
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