An Interdisciplinary Training Program to Transform Graduate Education In Genetics and Genomics

改变遗传学和基因组学研究生教育的跨学科培训计划

• 批准号: 10626138
• 负责人: Frank Wolfgang Albert
• 金额: $ 17.27万
• 依托单位: UNIVERSITY OF MINNESOTA
• 依托单位国家: 美国
• 财政年份: 2021
• 资助国家: 美国
• 起止时间: 2021-07-01 至 2026-06-30
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10626138
• 关键词: Genetic; Genomics; Graduate Education; Training Programs

PROJECT SUMMARY Genetics is a foundational discipline central to biomedical research and clinical practice. Our mission is to train geneticists for the 21st century. To achieve this goal, we have designed and implemented an interdisciplinary training program to transform graduate education in genetics and genomics at the University of Minnesota. Our Specific Aims are: (i) to provide students with rigorous and quantitative training in the fundamentals and state- of-the-art advances in genetics, genomics, and computational biology; (ii) to leverage the many collaborative research and educational strengths of our institution to provide new interdisciplinary student-centered graduate training opportunities that transcend departmental and collegiate boundaries; and (iii) to generate a diverse cohort of well-trained scientists able to integrate their broad skillset and their hunger for lifelong learning into their work across a multitude of careers in the biomedical workforce. This program will enable trainees to pursue many impactful career opportunities in academia, biotechnology, government, health care, or education created by recent advancements in genetics and genomics, including careers in fields that are undergoing rapid change, as well as careers in areas that do not presently exist or that are nascent. In recognition of the fact that the geneticists of tomorrow must possess quantitative acumen, we have not only developed new courses emphasizing bioinformatics and computational approaches, but we have also integrated these into our training program through a major redesign of the graduate curriculum pursuant to evaluation by internal and external review panels. In a sense, genetics and genomics are foundational fields that transcend and unify multiple disciplines within the biological sciences because what sets living things apart from inanimate objects is that all living things possess within them molecular blueprints for their construction, genomes. An impactful aspect of this academic and research training program is that it seeks to transcend traditional departmental boundaries by bringing together researchers from multiple disciplines within the biomedical sciences who utilize genetic and genomic analyses in their research. In so doing, this training program seeks to promote interdisciplinary research, foster collaborative team science, and implement individualized student-centered educational and career development programs. Our training program includes 50 highly productive and collaborative faculty from ten departments across five colleges at the University of Minnesota. We are seeking support for six PhD trainees for two years each beginning in year two of their academic program, with funding for year one provided by institutional funds. In addition to their thesis research, trainees will participate in professional development programs aimed at promoting their transition into and long-term success in biomedical science-related careers.

项目摘要 遗传学是生物医学研究和临床实践的基础学科。我们的使命是训练 21世纪的遗传学家为了实现这一目标，我们设计并实施了一个跨学科的 培训计划，以改变遗传学和基因组学的研究生教育在明尼苏达大学。我们 具体目标是：（一）为学生提供严格和定量的基础和国家培训- 在遗传学，基因组学和计算生物学的最先进的进展;（ii）利用许多合作 我们机构的研究和教育优势，以提供新的跨学科的以学生为中心的研究生 超越部门和学院界限的培训机会;以及（iii）产生多元化的 一群训练有素的科学家能够将他们广泛的技能和对终身学习的渴望融入到 他们在生物医学劳动力的众多职业中的工作。该计划将使学员能够 在学术界，生物技术，政府，医疗保健或教育领域寻求许多有影响力的职业机会 由遗传学和基因组学的最新进展创造，包括正在经历的领域的职业生涯 快速变化，以及目前不存在或新生领域的职业生涯。认识到 事实上，明天的遗传学家必须拥有定量的敏锐性，我们不仅开发了新的 课程强调生物信息学和计算方法，但我们也将这些整合到我们的 培训计划，通过根据内部和外部评估对研究生课程进行重大重新设计， 外部审查小组。从某种意义上说，遗传学和基因组学是超越和统一的基础领域 生物科学中的多个学科，因为生物与无生命物体的区别在于 所有生物体内都有构建它们的分子蓝图，即基因组。一个有影响力 这个学术和研究培训计划的一个方面是，它寻求超越传统的部门， 通过汇集来自生物医学科学多个学科的研究人员， 在他们的研究中利用遗传和基因组分析。在这样做的过程中，该培训计划旨在促进 跨学科研究，促进协作团队科学，并实施个性化的以学生为中心 教育和职业发展计划。我们的培训计划包括50名高生产力和 来自明尼苏达大学五个学院十个系的合作教师。我们正在寻求 为六名博士生提供为期两年的支持，每个人从学术课程的第二年开始， 第一年由机构资金提供。除了论文研究外，学员还将参加 专业发展计划，旨在促进他们的过渡和长期的成功， 生物医学相关的职业。

项目成果

Robust microtubule dynamics facilitate low-tension kinetochore detachment in metaphase.

• DOI: 10.1083/jcb.202202085
• 发表时间: 2023-08-07
• 期刊: The Journal of cell biology

PioABC-Dependent Fe(II) Oxidation during Photoheterotrophic Growth on an Oxidized Carbon Substrate Increases Growth Yield.

在氧化碳基质上光异养生长期间，PioABC 依赖性 Fe(II) 氧化可提高生长产量。

• DOI: 10.1128/aem.00974-22
• 发表时间: 2022
• 期刊: Applied and environmental microbiology
• 影响因子: 4.4
• 作者: Haas,NicholasW;Jain,Abhiney;Hying,Zachary;Arif,SabrinaJ;Niehaus,ThomasD;Gralnick,JeffreyA;Fixen,KathrynR
• 通讯作者: Fixen,KathrynR

An Immunogenic Model of KRAS-Mutant Lung Cancer Enables Evaluation of Targeted Therapy and Immunotherapy Combinations.

• DOI: 10.1158/0008-5472.can-22-0325
• 发表时间: 2022-10-04
• 期刊: Cancer research
• 影响因子: 11.2
• 作者: Boumelha J;de Carné Trécesson S;Law EK;Romero-Clavijo P;Coelho MA;Ng KW;Mugarza E;Moore C;Rana S;Caswell DR;Murillo M;Hancock DC;Argyris PP;Brown WL;Durfee C;Larson LK;Vogel RI;Suárez-Bonnet A;Priestnall SL;East P;Ross SJ;Kassiotis G;Molina-Arcas M;Swanton C;Harris R;Downward J
• 通讯作者: Downward J

Human APOBEC3B promotes tumor development in vivo including signature mutations and metastases.

• DOI: 10.1016/j.xcrm.2023.101211
• 发表时间: 2023-10-17
• 期刊: CELL REPORTS MEDICINE
• 影响因子: 14.3
• 作者: Durfee, Cameron;Temiz, Nuri Alpay;Levin-Klein, Rena;Argyris, Prokopios P.;Alsoe, Lene;Carracedo, Sergio;de la Vega, Alicia Alonso;Proehl, Joshua;Holzhauer, Anna M.;Seeman, Zachary J.;Liu, Xingyu;Lin, Yu-Hsiu T.;Vogel, Rachel I.;Sotillo, Rocio;Nilsen, Hilde;Harris, Reuben S.
• 通讯作者: Harris, Reuben S.

Reduction in O-GlcNAcylation Mitigates the Severity of Inflammatory Response in Cerulein-Induced Acute Pancreatitis in a Mouse Model.

• DOI: 10.3390/biology11030347
• 发表时间: 2022-02-22
• 期刊: Biology
• 影响因子: 4.2
• 作者: Moore M;Avula N;Wong A;Beetch M;Jo S;Alejandro EU
• 通讯作者: Alejandro EU