Airway inflammation in allergic aspergillosis: characterisation, immunologic mechanisms and treatment.

过敏性曲霉病的气道炎症：特征、免疫机制和治疗。

• 批准号: nhmrc : 100932
• 负责人: Prof Peter Gibson
• 金额: $ 16.17万
• 依托单位国家: 澳大利亚
• 项目类别: NHMRC Project Grants
• 财政年份: 2000
• 资助国家: 澳大利亚
• 起止时间: 2000-01-01 至 2002-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/airway-inflammation-allergic-mechanisms-treatment/82507
• 关键词: Airway; inflammation; allergic; aspergillosis; characterisation

Aspergillus fumigatus is a fungus that commonly occurs in our community. In some people with asthma, this fungus causes the asthma to become severe and chronic. It may also be associated with a severe form of lung destruction called bronchiectasis. There is little known about the chemicals produced by the body which contribute to inflammation in this condition. Similarly, it is not known why only some people with asthma develop an allergic disease to this fungus. In this project we will examine 2 important inflammation chemicals (called cytokines) to examine what their role is in aspergillus associated allergy. We will also examine 2 genetic markers to establish whether these predispose to people developing allergy to aspergillus. The treatment of aspergillus lung disease is also problematic. In this project we will examine whether a new medication called itraconazole is effective in removing this fungus from the airway and improving asthma.

烟曲霉是一种常见于我们社区的真菌。在一些哮喘患者中，这种真菌会导致哮喘变得严重和慢性。它也可能与一种称为支气管扩张的严重肺破坏有关。人们对这种情况下身体产生的导致炎症的化学物质知之甚少。同样，目前还不知道为什么只有一些哮喘患者对这种真菌过敏。在这个项目中，我们将研究2种重要的炎症化学物质（称为细胞因子），以研究它们在曲霉相关过敏中的作用。我们还将检查2种遗传标记，以确定这些标记是否易使人对曲霉素过敏。肺曲霉病的治疗也是有问题的。在这个项目中，我们将研究一种名为伊曲康唑的新药是否能有效地从气道中清除这种真菌并改善哮喘。