Elucidation of mechanisms by which fibre promotes or protects from colorectal tumorigenesis

阐明纤维促进或防止结直肠肿瘤发生的机制

• 批准号: nhmrc : 145784
• 负责人: Prof Peter Gibson
• 金额: $ 13.1万
• 依托单位: Monash University
• 依托单位国家: 澳大利亚
• 项目类别: NHMRC Project Grants
• 财政年份: 2001
• 资助国家: 澳大利亚
• 起止时间: 2001-01-01 至 2003-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/elucidation-mechanisms-fibre-colorectal-tumorigenesis/82472
• 关键词: Elucidation; mechanisms; fibre; promotes; protects

In a carefully controlled animal model of colon cancer development, dietary fibre can increase or decrease the likelihood of colon cancer development. It depends upon the type of fibre being fed to the animal. The mechanisms by which fibres can increase or decrease the likelihood of colon cancer developing are, however, poorly understood. In this proposal, we will attempt to elucidate at least some of the mechanisms. We plan to define whether animals consuming fibres that increase cancer development have factors in their faeces that affect the health of the cells that line the colon (the ones that form the cancers). This will be examined in both the test tube and in healthy rats. Whether fibres influence the access of these factors to the lining cells by sequestering or hiding the factors in the jelly-like consistency some fibres produce in the colon will also be examined. The results will help identify conditions in the faeces that alter the susceptibility of colons to developing cancer. By identifying these conditions, we can then apply our knowledge to human subjects, so that we might be able to identify those at a higher or lower risk of developing colon cancer and we can advise and (subsequently prove) ways of modifying diet to reduce the risk of colon cancer.

在仔细控制的结肠癌发展动物模型中，膳食纤维可以增加或减少结肠癌发展的可能性。这取决于喂给动物的纤维类型。然而，纤维可以增加或减少结肠癌发生的可能性的机制却知之甚少。在本提案中，我们将试图阐明至少部分机制。我们计划确定食用增加癌症发展的纤维的动物的粪便中是否有影响结肠细胞（形成癌症的细胞）健康的因素。这将在试管和健康大鼠中进行检查。纤维是否影响这些因素的访问衬里细胞通过隔离或隐藏的因素，在类似的一致性，一些纤维在结肠中产生的也将被检查。这些结果将有助于确定粪便中改变结肠对癌症易感性的条件。通过识别这些条件，我们可以将我们的知识应用于人类受试者，这样我们就可以识别出那些患结肠癌的风险较高或较低的人，我们可以建议并（随后证明）改变饮食以降低结肠癌风险的方法。