Medical Scientist National Research Service Award

医学科学家国家研究服务奖

• 批准号: 10869820
• 负责人: Marcus Ramsay Clark
• 金额: $ 17.42万
• 依托单位: UNIVERSITY OF CHICAGO
• 依托单位国家: 美国
• 财政年份: 2023
• 资助国家: 美国
• 起止时间: 2023-07-01 至 2028-06-30
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10869820
• 关键词: Medical; National Research Service Awards; Scientist

PROJECT SUMMARY The mission of The University of Chicago (UChicago) Medical Scientist Training Program (MSTP) is to train the next generation of clinician-scientists for impactful careers in the biomedical sciences. Impact is broadly defined as: providing fundamental insights into disease and relevant biological mechanisms, leading or making substantial contributions to translational efforts to identify better therapies and/or filling leadership roles that will determine how limited resources can best be used to improve human health. Our overall objective is to train outstanding and self-directed clinician scientists who can formulate and answer biologically and medically- important questions. To ensure the greatest impact, our program must reflect the diversity of the U.S. population in both who it trains and who it serves. To accomplish our mission and overall objective, we defined 15 specific and measurable objectives that stress the technical, operational and professional skills that support science identity and self-efficacy and are critical for a successful career as an independent biomedical investigator. Two unique features of the program enable our mission and provide an optimal training environment for the development of clinician-scientists. First, we are our own graduate program, the Interdisciplinary Scientist Training Program (ISTP). The ISTP allows integration of graduate and medical school classes in MS1, development of tailored curricula for each trainee, coordination across training transitions and uniform oversight and expectations during the graduate phase. Second, most trainees pursue a 1-4-3 progression of study rather than the traditional 2-4-2 progression. While trainees may pursue a 2-4-2, the 1-4-3 provides a continuous and in-depth graduate experience where trainees become well-trained scientists who can propose and rigorously test hypotheses. The 1-4-3 also provides a seamless transition between the preclinical and clinical phases which facilitates overall success in medical school. Multiple programmatic features ensure that fundamental scientific and clinical knowledge are interwoven to foster the development of impactful clinician-scientists. The UChicago MSTP enjoys sustained and substantial University financial backing including generous direct investment and support of facilities that cultivate innovative science. We are requesting 25 training slots to supplement University investments to support trainees for six of the typical eight years they spend in the MSTP. This requested investment by the NIH would constitute only 13% of total anticipated cost for our MSTP. We anticipate a program size of approximately 80 trainees and expect, based on our track record, that our trainees will contribute significantly to the U.S. biomedical enterprise.

项目总结 芝加哥大学医学科学家培训计划(MSTP)的使命是培训 下一代临床医生-科学家在生物医学科学中具有影响力的职业生涯。影响是广泛的 定义为：提供对疾病和相关生物机制的基本见解，领导或使 为翻译工作做出重大贡献，以确定更好的治疗方法和/或填补领导角色 确定如何最好地利用有限的资源来改善人类健康。我们的总体目标是培训 杰出的、自我指导的临床科学家，他们能够从生物和医学上阐述和回答- 重要的问题。为了确保最大的影响，我们的节目必须反映美国的多样性。 它培训的对象和服务的对象的人口。为了完成我们的使命和总目标，我们明确了 15具体和可衡量的目标，强调技术、操作和专业技能，以支持 科学认同感和自我效能感是独立生物医学成功职业生涯的关键 调查员。该计划的两个独特功能使我们的使命得以实现，并提供最佳培训 为临床医生-科学家提供发展的环境。首先，我们是我们自己的研究生课程， 跨学科科学家培训计划(ISTP)。ISTP允许研究生和医学的整合 MS1中的学校课程，为每个学员制定量身定做的课程，跨培训协调 毕业生阶段的过渡和统一的监督和期望。其次，大多数受训人员追求的是 1-4-3的学习进度，而不是传统的2-4-2进度。虽然学员可以选择2-4-2，但 1-4-3提供持续和深入的研究生经历，学员将成为训练有素的科学家 谁能提出并严格检验假说。1-4-3还提供了 临床前和临床阶段，有助于在医学院取得全面成功。多个方案 特色确保基础科学和临床知识交织在一起，促进 有影响力的临床医生-科学家。芝加哥大学MSTP享有持续和可观的大学资金 支持包括慷慨的直接投资和对培育创新科学的设施的支持。我们是 要求提供25个培训名额，以补充大学的投资，以支持典型的8个培训名额中的6个 他们在MSTP度过了数年。美国国立卫生研究院要求的这笔投资只占总投资的13% 我们MSTP的预期成本。我们预计计划规模约为80名实习生，并预计 根据我们的记录，我们的学员将为美国的生物医学事业做出重大贡献。

项目成果

Cardiac tissue engineering for the treatment of hypoplastic left heart syndrome (HLHS).

• DOI: 10.21037/tp-23-127
• 发表时间: 2023-08-30
• 期刊: Translational pediatrics
• 影响因子: 2

Statistically learning the functional landscape of microbial communities

统计了解微生物群落的功能景观

• DOI: 10.1038/s41559-023-02197-4
• 发表时间: 2023
• 期刊: Nature Ecology & Evolution
• 影响因子: 16.8
• 作者: Skwara, Abigail;Gowda, Karna;Yousef, Mahmoud;Diaz-Colunga, Juan;Raman, Arjun S.;Sanchez, Alvaro;Tikhonov, Mikhail;Kuehn, Seppe
• 通讯作者: Kuehn, Seppe