Ukraine HIV Research Training Program/Aging Supplement

项目概要/摘要 东欧和中欧艾滋病毒感染者（PLWH）对老龄化的了解有限。 亚洲（EECA）地区，包括正在经历武装冲突的乌克兰。艾滋病毒老龄化与 与老龄化有关的非传染性疾病（NCD）和身体表现，功能和活动从未 在乌克兰和东欧和中亚地区进行了估计，而没有在寿命更长的艾滋病毒携带者中进行评估。这 必须以艾滋病毒感染者为特征，并在整个艾滋病毒护理过程中反复评估，以确保 而在老年人中，老年人的生活比以往任何时候都要长寿。此应用程序是对 正在进行的Fogarty HIV研究培训赠款。我们将通过以下方式培训一名早期研究员（ESI） 实现两个目标。目标1包括艾滋病毒老龄化和老年学方面的高级教学培训， 在美国建立了（一个NIH资助的）项目以及其他活动。目标2包括收集试点数据 除了社会人口统计学和艾滋病毒变量（包括艾滋病毒载量和CD 4+计数）外，还对关键的老龄化指标进行了评估。 ESI将使用1）世界卫生组织国际分类， 功能、残疾和健康; 2）短期体能成套测验的组成部分，包括手 握力、4米步行和椅子站立; 3）WHO全球体力活动问卷。的ESI 还将评估非传染性疾病，包括肥胖;高血压;血脂、血糖和HbA 1c水平;糖尿病， 心血管疾病;精神健康非传染性疾病，包括抑郁症、创伤后应激障碍， 酒精和物质使用障碍。我们的ESI培训计划支持我们的试点研究的实施， 假设是，在以下人群中观察到较低的身体表现、功能和活动的患病率： 感染艾滋病毒/艾滋病的人患非传染性疾病的比例更高。这将在控制不力的艾滋病毒携带者中加剧， 注射毒品使用者、老年人和男性，并经历与战争有关的创伤。这种创新的组合， 乌克兰ESI的艾滋病毒老龄化高级教学加实践研究培训是乌克兰的第一个， EECA。在年龄较大的艾滋病毒感染者中，我们将使用标准化和有效的临床方法来评估艾滋病毒老化 再加上非传染性疾病和艾滋病毒相关因素。这种训练可以在一年内完成。试点研究结果将 为干预措施的制定提供信息，以1）解决实足老龄化问题以及艾滋病毒/非传染性疾病护理的连续性 在乌克兰的PLWH中，2）为衰老过程的前瞻性观察研究提供基础 在乌克兰的PLWH。这将建立在母D43的基础上，并与解决 战争引发的人道主义危机。

PROJECT SUMMARY/ABSTRACT Limited knowledge exists about aging among people living with HIV (PLWH) in the Eastern European and Central Asia (EECA) region including Ukraine which is experiencing armed conflict. The intersection of HIV-aging with aging-related noncommunicable diseases (NCDs) and physical performance, function and activity has never been estimated in Ukraine and the EECA, and not evaluated among PLWH who are living to older ages. This must be characterized in PLWH and repeatedly assessed across the HIV care continuum to ensure quality of life among PLWH who are reaching ages older than ever observed. This application is a supplement to the ongoing Fogarty HIV Research Training Grant. We will train one Early Stage Investigator (ESI) by accomplishing two Aims. Aim 1 includes advanced didactic training in HIV-aging and Gerontology via two well- established (one NIH-funded) programs in the US plus additional activities. Aim 2 includes collecting pilot data on key aging metrics in addition to sociodemographic and HIV variables including HIV viral load and CD4+ count. The ESI will assess physical performance, function and activity using 1) the WHO International Classification of Functioning, Disability and Health; 2) components of the Short Physical Performance Battery, including hand grip strength, 4-meter walk, and chair stands; and 3) the WHO Global Physical Activity Questionnaire. The ESI will also assess NCDs, including obesity; hypertension; blood lipid, glucose and HbA1c levels; diabetes, cardiovascular disease; and mental health NCDs including depression, post-traumatic stress disorder, and alcohol and substance use disorders. Our ESI training plan supports implementation of our pilot study, with the hypothesis is that the prevalence of lower physical performance, function and activity, will be observed among PLWH who have higher levels of NCDs. This will be exacerbated among PLWH who are poorly controlled, injection drug users, older, and men, and experience war related trauma. This innovative combination of advanced didactic plus hands-on research training in HIV-aging of one Ukrainian ESI is the first in Ukraine and the EECA. Among older PLWH we will use standardized and validated clinical approaches to assess HIV-aging in combination with NCDs and HIV-related factors. This training is achievable in one year. Pilot study results will inform development of interventions to 1) address chronological aging together with the HIV/NCD care continuum among PLWH in Ukraine, and 2) provide a foundation for prospective observational studies of aging processes in PLWH in Ukraine. This will build on the parent D43 and is in alignment with the theme of addressing the humanitarian crisis sparked by the war.