Ukraine HIV Research Training Program/Aging Supplement

项目摘要/摘要 东欧和中欧艾滋病毒携带者(PLWH)对老龄化的了解有限 正在经历武装冲突的包括乌克兰在内的亚洲(东非经委会)区域。艾滋病毒-老龄化与 与衰老相关的非传染性疾病(NCDs)和身体表现、功能和活动从未 在乌克兰和欧洲经委会进行了估计，但没有在活到高龄的PLWH中进行评估。这 必须以公共卫生医院为特征，并在整个艾滋病毒护理连续过程中反复评估，以确保质量 PLWH中的生命正在达到比观察到的年龄更大的年龄。此应用程序是对 正在进行的Fogarty艾滋病毒研究培训补助金。我们将通过以下方式培训一名早期调查员(ESI) 实现两个目标。目标1包括艾滋病毒-老龄化和老年学方面的高级教学培训，通过两个良好的- 在美国建立(一个由美国国立卫生研究院资助的)项目，外加额外的活动。目标2包括收集飞行员数据 除了社会人口和艾滋病毒变量外，关键的老龄化指标还包括艾滋病毒病毒载量和CD4计数。 ESI将评估身体表现、功能和活动，使用1)世卫组织国际分类 功能、残疾和健康；2)短物理性能电池的组件，包括手 握力、4米步行和椅子站立；以及3)世界卫生组织全球体力活动问卷。ESI 还将评估非传染性疾病，包括肥胖；高血压；血脂、血糖和糖化血红蛋白水平；糖尿病， 心血管疾病；以及精神健康非传染性疾病，包括抑郁症、创伤后应激障碍和 酒精和药物使用障碍。我们的ESI培训计划支持我们的试点研究的实施， 假设身体表现、机能和活动量较低的人将在 非传染性疾病水平较高的PLWH。这种情况将在控制不佳的PLWH中加剧， 注射吸毒者，老年人和男性，并经历与战争有关的创伤。这一创新的组合 一名乌克兰人的艾滋病毒老化高级教学加实践研究培训在乌克兰是第一次， 欧洲经济共同体。在老年PLWH中，我们将使用标准化和有效的临床方法来评估艾滋病毒的老化 与非传染性疾病和艾滋病毒相关因素相结合。这项培训可以在一年内完成。试点研究结果将 告知制定干预措施，以1)与艾滋病毒/非传染性疾病护理连续体一起解决按时间顺序老龄化问题 在乌克兰的PLWH中，以及2)为老龄化过程的前瞻性观察研究提供了基础 在乌克兰的PLWH。这将建立在父D43的基础上，并与解决 战争引发的人道主义危机。

PROJECT SUMMARY/ABSTRACT Limited knowledge exists about aging among people living with HIV (PLWH) in the Eastern European and Central Asia (EECA) region including Ukraine which is experiencing armed conflict. The intersection of HIV-aging with aging-related noncommunicable diseases (NCDs) and physical performance, function and activity has never been estimated in Ukraine and the EECA, and not evaluated among PLWH who are living to older ages. This must be characterized in PLWH and repeatedly assessed across the HIV care continuum to ensure quality of life among PLWH who are reaching ages older than ever observed. This application is a supplement to the ongoing Fogarty HIV Research Training Grant. We will train one Early Stage Investigator (ESI) by accomplishing two Aims. Aim 1 includes advanced didactic training in HIV-aging and Gerontology via two well- established (one NIH-funded) programs in the US plus additional activities. Aim 2 includes collecting pilot data on key aging metrics in addition to sociodemographic and HIV variables including HIV viral load and CD4+ count. The ESI will assess physical performance, function and activity using 1) the WHO International Classification of Functioning, Disability and Health; 2) components of the Short Physical Performance Battery, including hand grip strength, 4-meter walk, and chair stands; and 3) the WHO Global Physical Activity Questionnaire. The ESI will also assess NCDs, including obesity; hypertension; blood lipid, glucose and HbA1c levels; diabetes, cardiovascular disease; and mental health NCDs including depression, post-traumatic stress disorder, and alcohol and substance use disorders. Our ESI training plan supports implementation of our pilot study, with the hypothesis is that the prevalence of lower physical performance, function and activity, will be observed among PLWH who have higher levels of NCDs. This will be exacerbated among PLWH who are poorly controlled, injection drug users, older, and men, and experience war related trauma. This innovative combination of advanced didactic plus hands-on research training in HIV-aging of one Ukrainian ESI is the first in Ukraine and the EECA. Among older PLWH we will use standardized and validated clinical approaches to assess HIV-aging in combination with NCDs and HIV-related factors. This training is achievable in one year. Pilot study results will inform development of interventions to 1) address chronological aging together with the HIV/NCD care continuum among PLWH in Ukraine, and 2) provide a foundation for prospective observational studies of aging processes in PLWH in Ukraine. This will build on the parent D43 and is in alignment with the theme of addressing the humanitarian crisis sparked by the war.