Siyakhula: Growing HIV/TB Research Knowledge for Growing Healthy Kids in Eswatini

Siyakhula：为斯威士兰的健康儿童增长艾滋病毒/结核病研究知识

• 批准号: 10871957
• 负责人: ANNA M MANDALAKAS
• 金额: $ 10万
• 依托单位: BAYLOR COLLEGE OF MEDICINE
• 依托单位国家: 美国
• 财政年份: 2021
• 资助国家: 美国
• 起止时间: 2021-07-12 至 2026-03-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10871957
• 关键词: Aging; Antitubercular Antibiotics; Applied Research; Carotenoids; Child; Collaborations; Cutaneous; DNA Methylation; Development; Diabetes Mellitus; Dimensions; Disease; Epigenetic Process; Foundations; Funding; HIV; HIV antiretroviral; HIV/AIDS; HIV/TB; Health; Inflammaging; Knowledge; Longevity; Malnutrition; Mass Spectrum Analysis; Measures; Medicine; Mentors; Mentorship; Methods; Morbidity - disease rate; Nutritional; Pilot Projects; Premature aging syndrome; Research; Research Personnel; Research Training; Series; Tanzania; Technology Transfer; Training; Training Programs; Tuberculosis; Universities; college; experience; lectures; mortality; novel; nutrition; premature; programs; social factors; symposium; telomere

Program Summary/Abstract The Eswatini-Baylor Children’s Foundation, University of of Eswatini (UNESWA) and Baylor College of Medicine will conduct health research training in HIV and Tuberculosis (TB) induced premature aging in conjunction with the existing D43 “Siyakhula” training program. Supplemental funds will support integration of premature aging research training within all aspects of Siyakhula including mentorship, pilot project development and implementation, and implementation of novel methods to measure and document post- infectious premature aging. The additional training will be seamlessly integrated into the existing conference series and applied research training program and introduce additional complementary capacity building activities. Despite successful antiretrovirals for HIV/AIDS and despite successful antibiotics for TB, there remains increased morbidity and mortality and 5-12 years of premature aging. This one year supplemental funding proposal will collaborate with researchers in Tanzania (Drs. Mkunde Chachage and Lucy Mrema) to share their experiences and mentor Eswatini researchers in inflammaging and the detrimental bidirectional effects on diabetes and HIV on premature aging. Dr. Fred Moonga (UNESWA) will provide lectures and mentorship on social factors leading to premature aging. From BCM, Drs. Moran and DiNardo will provide lectures and mentorship in nutrition across the lifespan and epigenetic mechanisms of premature aging, respectively. The supplement will fund five to eight of the top pilot projects to help train Eswatini researchers in HIV induced premature aging-related projects. Key projects will be chosen to focus on integrating HIV/AIDS with non- communicable diseases, to document the ill effects of premature aging. Similarly, key projects that help transfer technology to measure premature epigenetic aging (telomere qPCR, DNA methylation) or document the ill effects between malnutrition and premature aging (cutaneous carotenoid or mass-spectroscopy based nutritional methods). The projects will address the multidimensional means by which HIV/AIDS and TB induce premature aging, and train Eswatini researchers how to measure and begin to mitigate premature aging.

计划摘要/摘要 埃斯瓦蒂尼-贝勒儿童基金会、埃斯瓦蒂尼大学和贝勒学院 医学界将在#年就艾滋病毒和结核病(TB)引起的过早衰老进行健康研究培训 与现有的D43“Siyakhula”培训方案相结合。补充资金将支持整合 Siyakhula方方面面的早衰研究培训，包括指导、试点项目 制定和实施新的方法来衡量和记录后继工作 感染性早衰。额外的培训将无缝地并入现有的会议 系列和应用研究培训计划，并引入额外的补充能力建设 活动。 尽管艾滋病毒/艾滋病的抗逆转录病毒药物取得了成功，结核病的抗生素也取得了成功，但仍有 发病率和死亡率的增加以及5-12年的过早衰老。这一年的补充资金 提案将与坦桑尼亚的研究人员(Mkunde Chachage博士和Lucy Mrema博士)合作，分享他们的 埃斯瓦蒂尼研究人员在炎症及其有害的双向影响方面的经验和指导 糖尿病和艾滋病毒对早衰的影响。弗雷德·莫昂加博士将在以下方面提供讲座和指导 导致过早衰老的社会因素。来自BCM的莫兰博士和迪纳多博士将提供讲座和 生命周期中的营养指导和过早衰老的表观遗传机制。 该补充资金将资助五到八个顶级试点项目，以帮助培训埃斯瓦蒂尼的研究人员在艾滋病毒诱导下 与过早老龄化相关的项目。将选择重点项目，重点将艾滋病毒/艾滋病与非 传染病，以证明过早衰老的不良影响。同样，帮助 用于测量表观遗传过早老化的转移技术(端粒qPCR、DNA甲基化)或文献 营养不良和过早衰老之间的不良影响(基于皮肤类胡萝卜素或质谱学) 营养方法)。这些项目将解决艾滋病毒/艾滋病和结核病引发的多方面问题 并培训Eswatini研究人员如何测量和开始缓解过早衰老。