Siyakhula: Growing HIV/TB Research Knowledge for Growing Healthy Kids in Eswatini

Siyakhula：为斯威士兰的健康儿童增长艾滋病毒/结核病研究知识

• 批准号: 10871957
• 负责人: ANNA M MANDALAKAS
• 金额: $ 10万
• 依托单位: BAYLOR COLLEGE OF MEDICINE
• 依托单位国家: 美国
• 财政年份: 2021
• 资助国家: 美国
• 起止时间: 2021-07-12 至 2026-03-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10871957
• 关键词: Aging; Antitubercular Antibiotics; Applied Research; Carotenoids; Child; Collaborations; Cutaneous; DNA Methylation; Development; Diabetes Mellitus; Dimensions; Disease; Epigenetic Process; Foundations; Funding; HIV; HIV antiretroviral; HIV/AIDS; HIV/TB; Health; Inflammaging; Knowledge; Longevity; Malnutrition; Mass Spectrum Analysis; Measures; Medicine; Mentors; Mentorship; Methods; Morbidity - disease rate; Nutritional; Pilot Projects; Premature aging syndrome; Research; Research Personnel; Research Training; Series; Tanzania; Technology Transfer; Training; Training Programs; Tuberculosis; Universities; college; experience; lectures; mortality; novel; nutrition; premature; programs; social factors; symposium; telomere

Program Summary/Abstract The Eswatini-Baylor Children’s Foundation, University of of Eswatini (UNESWA) and Baylor College of Medicine will conduct health research training in HIV and Tuberculosis (TB) induced premature aging in conjunction with the existing D43 “Siyakhula” training program. Supplemental funds will support integration of premature aging research training within all aspects of Siyakhula including mentorship, pilot project development and implementation, and implementation of novel methods to measure and document post- infectious premature aging. The additional training will be seamlessly integrated into the existing conference series and applied research training program and introduce additional complementary capacity building activities. Despite successful antiretrovirals for HIV/AIDS and despite successful antibiotics for TB, there remains increased morbidity and mortality and 5-12 years of premature aging. This one year supplemental funding proposal will collaborate with researchers in Tanzania (Drs. Mkunde Chachage and Lucy Mrema) to share their experiences and mentor Eswatini researchers in inflammaging and the detrimental bidirectional effects on diabetes and HIV on premature aging. Dr. Fred Moonga (UNESWA) will provide lectures and mentorship on social factors leading to premature aging. From BCM, Drs. Moran and DiNardo will provide lectures and mentorship in nutrition across the lifespan and epigenetic mechanisms of premature aging, respectively. The supplement will fund five to eight of the top pilot projects to help train Eswatini researchers in HIV induced premature aging-related projects. Key projects will be chosen to focus on integrating HIV/AIDS with non- communicable diseases, to document the ill effects of premature aging. Similarly, key projects that help transfer technology to measure premature epigenetic aging (telomere qPCR, DNA methylation) or document the ill effects between malnutrition and premature aging (cutaneous carotenoid or mass-spectroscopy based nutritional methods). The projects will address the multidimensional means by which HIV/AIDS and TB induce premature aging, and train Eswatini researchers how to measure and begin to mitigate premature aging.

项目概要/摘要 斯威士兰-贝勒儿童基金会、斯威士兰大学和贝勒大学 医学将在艾滋病毒和结核病（TB）引起的过早衰老方面进行健康研究培训， 与现有的D43“Siyakhula”培训计划结合使用。补充资金将支持 在Siyakhula的各个方面进行过早衰老研究培训，包括指导，试点项目 开发和实施，并实施新的方法来衡量和记录后， 传染性过早衰老额外的培训将与现有的会议无缝整合 系列和应用研究培训计划，并引入额外的补充能力建设 活动 尽管成功的抗逆转录病毒治疗艾滋病毒/艾滋病，尽管成功的抗生素治疗结核病， 发病率和死亡率增加，过早衰老5-12年。这一年的补充资金 该提案将与坦桑尼亚的研究人员（Mkunde Chachage博士和Lucy Mrema博士）合作，分享他们的 在炎症和有害的双向影响方面拥有丰富的经验并指导斯威士兰的研究人员 糖尿病和艾滋病对过早衰老的影响Fred Moonga博士（UNESWA）将提供以下方面的讲座和指导 导致过早衰老的社会因素。从2013年开始，莫兰博士和迪纳多博士将提供讲座， 在营养的整个生命周期和过早衰老的表观遗传机制，分别导师。 该补充资金将资助五到八个顶级试点项目，以帮助培训斯威士兰的艾滋病毒诱导研究人员。 过早老化相关项目。将选择重点项目，将艾滋病毒/艾滋病与非艾滋病毒/艾滋病相结合， 传染性疾病，记录过早衰老的不良影响。同样，帮助 转移技术来测量过早的表观遗传衰老（端粒qPCR，DNA甲基化）或记录 营养不良和过早衰老之间的不良影响（皮肤类胡萝卜素或基于质谱的 营养方法）。这些项目将解决艾滋病毒/艾滋病和结核病引起的多方面问题 过早衰老，并培训斯威士兰研究人员如何测量和开始减轻过早衰老。