Siyakhula: Growing HIV/TB Research Knowledge for Growing Healthy Kids in Eswatini

Siyakhula：为斯威士兰的健康儿童增长艾滋病毒/结核病研究知识

• 批准号: 10241841
• 负责人: ANNA M MANDALAKAS
• 金额: $ 30.28万
• 依托单位: BAYLOR COLLEGE OF MEDICINE
• 依托单位国家: 美国
• 财政年份: 2021
• 资助国家: 美国
• 起止时间: 2021-07-12 至 2026-03-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10241841
• 关键词: AIDS/HIV problem; Adolescent; Affect; Applied Research; Area; Back; Behavioral Sciences; Bioinformatics; Biometry; Child; Child Health; Childhood; Clinical Research; Collaborations; Communities; Country; Doctor of Philosophy; Educational process of instructing; Enrollment; Ensure; Epidemic; Epidemiology; Funding; Future; Goals; HIV; HIV/TB; Health; Health Professional; Health Promotion; Health Promotion Sciences; Health system; Infant; Institution; Investigation; Knowledge; Lead; Master of Public Health; Medicine; Mentors; Pediatrics; Policies; Population; Public Health; Public Health Schools; Research; Research Infrastructure; Research Methodology; Research Personnel; Research Priority; Scientist; Texas; Training; Training Programs; Translational Research; Tuberculosis; United States National Institutes of Health; Universities; base; behavioral health; cohort; college; comorbidity; environmental enrichment for laboratory animals; international center; mortality; multidisciplinary; next generation; novel; pediatric human immunodeficiency virus; programs; skills; success

Program Summary/Abstract In collaboration with the University of Eswatini and the Eswatini Ministry of Health (including national HIV and TB programs), Baylor College of Medicine (BCM) will conduct training in HIV/AIDS research methods with a focus on pediatrics and Tuberculosis (TB) co-morbidity. Other key partners include The University of Texas School of Public Health (UTHealth SPH) who will support and mentor long-term trainees during Public Health Masters and Doctoral level studies. Our collaborative HIV/TB training program will train i) three doctoral candidates to become Independent Investigators in clinical and translational research focusing on HIV/TB in pediatric (infants, children, and adolescents) populations, and ii) two in-country cohorts of public health trainees to become Associate Investigators in child health research. The training capitalizes on a novel Eswatini-US dual mentoring strategy to ensure retention, success, and relevance of research conducted by US-based long-term Siyakhula Scholars. Long-term Siyakhula Scholars will enroll in UTHealth SPH to earn a PhD or DrPH and conduct thesis activities in Eswatini engaging in-country Siyakhula Scholars and mentors. We will employ a "teach-back" approach in which the long-term trainees participate in Eswatini-based training forums to develop teaching skills and strengthen partnerships with in-country scholars. Our goal is to strengthen clinical research capacity in Eswatini while simultaneously producing high-quality researchers who will successfully transition to independence, obtain independent funding and lead national efforts to end the HIV/TB epidemic, now the leading infectious causes of mortality globally. We have developed a training plan that has adapted to today's HIV research priorities appropriately focused on TB specific comorbidity while being aligned with the Eswatini National Research Strategy and priorities of the US NIH and Fogarty International Center. Building on our past successes, we will train the next generation of HIV scientists in four essential programmatic areas including epidemiology, biostatistics and bio-informatics, behavioral science and health promotion, and health systems management and policy. We will develop capacity in these cornerstones of multidisciplinary clinical and translational research by accomplishing the following specific aims: 1) Capitalize on existing pediatric HIV expertise to enhance investigation of HIV/TB co-affected children and provide long-term training to produce Independent Emaswati Investigators in the most recent advances in the fields of epidemiology, biostatistics & bio-informatics, behavioral science & health promotion, and health systems management & policy; 2) Provide intensive in-country training in Child Health Applied Research Methods to well-qualified Siyakhula Scholars from partner institutions in Eswatini; 3) Support local research infrastructure and the existing research community while enriching the environment and capacity to support educational research opportunities for future health professionals.

计划摘要/摘要 与埃斯瓦蒂尼大学和埃斯瓦蒂尼卫生部(包括国家艾滋病毒和艾滋病)合作 结核病计划)，贝勒医学院(BCM)将与 重点关注儿科和结核病(TB)的共同发病率。其他主要合作伙伴包括德克萨斯大学 公共卫生学院(UTHealth SPH)将在公共卫生期间支持和指导长期受训人员 攻读硕士和博士学位。我们的合作艾滋病毒/结核病培训计划将培养1)三名博士 候选人将成为以艾滋病毒/结核病为重点的临床和翻译研究的独立研究员 儿科(婴儿、儿童和青少年)人群，以及二)国内两批公共卫生实习生 成为儿童健康研究的副研究员。这项训练利用了一种新的埃斯瓦蒂尼-美国双重身份 指导战略，以确保美国长期研究中心进行的研究的保留、成功和相关性 锡亚库拉学者。长期的Siyakhula学者将注册UTHealth SPH以获得博士或博士学位，并 在埃斯瓦蒂尼开展论文活动，参与国家Siyakhula学者和导师。我们将聘请一名 “回授”方式，即长期受训人员参加以埃斯瓦蒂尼为基础的培训论坛，以发展 教授技能，并加强与国内学者的伙伴关系。我们的目标是加强临床研究 埃斯瓦蒂尼的生产能力，同时培养出高素质的研究人员，他们将成功过渡到 独立，获得独立资金，并领导国家努力结束艾滋病毒/结核病流行，现在是主要的 在全球范围内造成死亡的传染性原因。我们已经制定了一项适应当今艾滋病毒的培训计划 研究重点适当地集中在结核病特有的合并症上，同时与Eswatini保持一致 美国国立卫生研究院和福格蒂国际中心的国家研究战略和优先事项。在我们过去的基础上继续前进 为了取得成功，我们将在四个基本方案领域培训下一代艾滋病毒科学家，包括 流行病学、生物统计学和生物信息学、行为科学和健康促进以及卫生系统 管理和政策。我们将在这些多学科临床和临床的基石上发展能力 通过实现以下具体目标进行转译研究：1)利用现有的儿科艾滋病毒 专门知识，以加强对艾滋病毒/结核病共同感染儿童的调查，并提供长期培训，以产生 埃马斯瓦蒂独立调查人员在流行病学、生物统计学和 生物信息学、行为科学与健康促进、健康系统管理与政策；2)提供 强化国内儿童健康培训--将研究方法应用于优秀的锡亚胡拉学者 埃斯瓦蒂尼的伙伴机构；3)支持当地研究基础设施和现有的研究社区 在丰富环境和能力的同时，支持未来健康的教育研究机会 专业人士。