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The University of Arizona Wound Care Center Clinical Research Unit

亚利桑那大学伤口护理中心临床研究单位

基本信息

批准号：
10877642
负责人：
GEOFFREY C GURTNER
金额：
$ 20万
依托单位：
UNIVERSITY OF ARIZONA
依托单位国家：
美国
项目类别：
财政年份：
2018
资助国家：
美国
起止时间：
2018-09-15 至 2027-12-31
项目状态：
未结题

来源：
https://reporter.nih.gov/project-details/10877642
关键词：
Acceleration Address Adherence Adult Affect American American Indians Amputation Ancillary Study Arizona Bioinformatics Biological Markers Blood Glucose Blood Vessels Blood flow Caring Cells Chairperson Clinical Clinical Research Clinical Trials Clinical Trials Network Collaborations Collection Communities Community Actions Complex Data Debridement Dedications Diabetes Mellitus Diabetic Foot Diabetic Foot Ulcer Education Educational Status Environment Ethnic Origin FDA approved Foundations Funding Grant Health Heterogeneity Hispanic Hispanic Populations Human Individual Infrastructure Institution International Intervention Latino Limb Salvage Lower Extremity Medical Medicine Minority Mission National Institute of Diabetes and Digestive and Kidney Diseases Native Americans Operative Surgical Procedures Pathologic Pathology Patient Care Patient Recruitments Patients Persons Physicians Podiatry Population Positioning Attribute Prevalence Problem Solving Publications Recommendation Recording of previous events Recurrence Reporting Research Resource Sharing Role Sampling Services Site Socioeconomic Status Source Surgeon Techniques Testing Tissues Trauma United States United States Indian Health Service United States National Institutes of Health Universities Work academic program bench to bedside biomarker identification biomarker validation chronic wound clinical care clinical center clinical research site college comorbidity compliance behavior contextual factors demographics design diabetic diabetic patient diabetic wound healing drug candidate experience healing higher education improved innovation interdisciplinary approach limb amputation mortality multidisciplinary open wound outcome prediction outreach outreach program patient population predictive marker prevent programs provider adherence recruit single-cell RNA sequencing social social deprivation social factors social health determinants standard of care treatment planning wound wound care wound healing

项目摘要

PROJECT SUMMARY Approximately 25% of diabetic patients experience diabetic foot ulcers (DFUs). This is a significant clinical problem since there are no effective biomarkers for predicting outcomes, no drug candidates that have recently been FDA-approved and no therapies that are widely effective in treatment. Additionally, the prevalence of diabetes and non-healing DFUs are highest among minorities, such as in Native American and Hispanic populations, and associated with social deprivation and high mortality. The University of Arizona (UArizona) is the leading public research university in the American Southwest and an ideal transdisciplinary research community for studying DFU healing. The partnership between UArizona and Banner Health provided service to 5,680 patients with open wounds last year. Ranging from trauma to podiatry, Banner Health saw 3,770 individuals with diabetic foot ulcers (DFUs) in the past 3 years. Dr. Geoffrey Gurtner has an established history in studying both late-stage biomarker validation through clinical trials and also mechanistic and early-stage biomarkers identification through the collection of many high-quality biosamples and longitudinal data (Aim 1). This is supported by both the large patient population at UArizona as well as Dr. Gurtner’s history in identifying rate cell subpopulations in DFU samples collected from human patients. Next, we aim to create a unified Standard of Care through the execution of high-quality clinical trials for DFUs, which historically have been difficult to recruit, and also by collecting high-quality data to address the heterogeneity of DFUs with complex pathologies, co-morbidities, and social factors. At UArizona, Dr. Gurtner and Dr. Zhou conduct high-quality clinical trials and have access to a wide distribution of patients and a range of techniques to make sure that “No DFU Patient Goes Unstudied” (Aim 2). Next, our diverse patient pool will allow us to specifically understand how social and environmental contextual factors (“social determinants of health”; SDH) may affect diabetic healing and biomarkers, specifically be recruiting over a diverse and expansive patient pool (Aim 3). Finally, we have access to not just the entire Banner Health Network (BHN), but also to the Indian Health Network and outreach programs for Latino communities. Through this expansive network that incorporates people of all demographics and socio-economic statuses, we will establish effective collaborations between the CRU and new clinical sites to generate cooperative problem-solving and high-level training, with shared resources and values (Aim 4).

项目总结