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中文摘要
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摘要: 核心A(行政核心)由该计划的PD/PI Joe“Skip”G.N.领导。加西亚医学博士,他将提供 对项目和行政运作进行必要的监督,以确保项目的全面指导和组织。 整个方案。加西亚博士和核心A成员将负责项目指导和评估, 项目运作,财政和科学监督。他们将组织每月的PPG会议,与 PPG的内部和外部科学审查小组和PPG领导人,并协调PPG的活动。的 PPG核心A计划和赠款管理员/研究协调员,直接向加西亚博士报告,将处理 日常研究细节(除了机构内和机构间的研究项目协调/监督外, 核心和试剂交换的项目利用率)和日常行政细节(财务和 行政业务)。此外,该核心将提供会计支持,以确保适当的 财政和科学监督、监测和遵守联邦和机构赠款管理 通过各种正式机制,后者。行政核心的目标是: 集中所有行政行动和财务记录保存;(ii)编制科学和财务报告 按照大学和NHLBI的要求;(iii)确保PPG研究符合最高标准 通过内部和外部审查小组的定期审查; ㈣促进共同资源的使用; (v)每月向项目和核心项目提供所有支出的审查,并处理 大学会计和赠款办公室有关赠款预算;(六)提供交流场所 促进科学信息和思想的交流,并允许PPG之间高度无缝的沟通, 芝加哥和图森的科学家;(七)协调联合大学和 除了年度ATS会议外,UIC调查员还参加了在图森和/或芝加哥举行的季度会议。 由于这种沟通对项目的成功至关重要,核心A人员将精心制作视频 召开以下会议:i)单个项目和核心团队的每周会议,ii) 项目委员会(由核心A负责人和PPG PD/PI领导),项目和核心负责人讨论科学 和行政事务,以及iii)定期的每月研究研讨会,使PPG研究人员能够提出 他们的工作进展到其他研究人员。在此A1 PPG续期申请中,核心A将促进工作流程 在芝加哥和图森之间,特别是关于核心B,C和D实验和临界交换 项目之间的试剂。最后,核心A将协调项目间、部门间和部门间的 机构合作安排,并在认为有必要的情况下, 整个项目的进度。这些协调一致的行政服务将共同确保 最佳的财务实践,促进PPG科学家之间频繁和富有成效的沟通, 促进高质量的科学互动,以实现这一翻译PPG的目标。
英文摘要
ABSTRACT: The Core A (Administrative Core) is led by the Program's PD/PI, Joe “Skip” G.N. Garcia MD, who will provide essential oversight of program and administrative operations to ensure overall direction and organization of the entire Program. Dr. Garcia and Core A members will be responsible for program direction and evaluation, program operations, and fiscal and scientific oversight. They will organize monthly PPG meetings, work with the PPG's Internal and External Scientific Review Panels and PPG Leaders, and coordinate PPG activities. The PPG Core A Program and Grant Administrator/Research Coordinator, reporting directly to Dr. Garcia, will handle day-to-day research details (research project coordination/oversight in addition to intra- and inter-institutional project utilization of the Cores and reagents exchange) and day-to-day administrative details (financial and administrative operations). In addition, this Core will provide accounting support that will ensure appropriate fiscal and scientific oversight, monitoring and compliance with federal and institutional grant management regulations, the latter through several formal mechanisms. The objectives of the Administrative core are: (i) to centralize all administrative actions and financial recording keeping; (ii) to prepare scientific and financial reports as required by the university and the NHLBI; (iii) to ensure that the PPG research meets the highest standards through periodic review by the internal and external review panels; (iv) to facilitate the use of common resources; (v) to provide the projects and cores with a review of all expenditures on a monthly basis as well as dealing with University Accounting and Grants offices concerning grant budgets; (vi) to provide the communication venues that foster exchange of scientific information and ideas and allow highly seamless communication between PPG scientists in Chicago and Tucson; (vii) to coordinate the regular virtual or in-person retreats between UA and UIC investigators for quarterly meetings, in Tucson and/or Chicago, in addition to the annual ATS conference. As this communication is vital to the success of the program, Core A personnel, will orchestrate the video conferencing of the: i) weekly meetings of individual Project and Core teams, ii) biweekly meetings of the Program Committee (led by Core A Leader and PPG PD/PI) where Project and Core leaders discuss scientific and administrative matters, and iii) regular monthly research seminars that will allow PPG investigators to present their work in progress to other researchers. In this A1 PPG renewal application, Core A will facilitate workflow between Chicago and Tucson, especially with regard to Core B, C, and D experiments and the critical exchange of reagents between Projects. Finally, Core A will coordinate the inter-project, inter-departmental, and inter- institutional collaborative arrangements and evolve new arrangements as deemed necessary for the scientific progress of the Program Project as a whole. Together, these coordinated administrative services will ensure optimal financial practices, facilitate frequent and productive communications between PPG scientists, and promote the high quality scientific interactions necessary to meet the goals of this translational PPG.
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Preclinical Development of a Novel eNAMPT-Neutralizing mAb for Pulmonary Hypertension
  • 批准号:
    10723260
  • 项目类别:
  • 资助金额:
    $80.9万
  • 财政年份:
    2022
  • 负责人:
    Joe G. N. Garcia
  • 依托单位:
Role of Endothelial eNAMPT Secretion and TLR4 Signaling in the ARDS Vascular Endotype
  • 批准号:
    10440855
  • 项目类别:
  • 资助金额:
    $23.27万
  • 财政年份:
    2022
  • 负责人:
    Joe G. N. Garcia
  • 依托单位:
Preclinical Development of a Novel eNAMPT-Neutralizing mAb for Pulmonary Hypertension
  • 批准号:
    10489982
  • 项目类别:
  • 资助金额:
    $25.96万
  • 财政年份:
    2022
  • 负责人:
    Joe G. N. Garcia
  • 依托单位:
Targeting the eNAMPT/TLR4 pathway to reduce Inflammatory Bowel Disease severity
  • 批准号:
    10771493
  • 项目类别:
  • 资助金额:
    $97.52万
  • 财政年份:
    2022
  • 负责人:
    Joe G. N. Garcia
  • 依托单位:
海外基金