Research Training Center for Botanicals and Chronic Diseases in Tajikistan and Indonesia

塔吉克斯坦和印度尼西亚植物药和慢性病研究培训中心

• 批准号: 10878049
• 负责人: ILYA RASKIN
• 金额: $ 25.6万
• 依托单位: RUTGERS, THE STATE UNIV OF N.J.
• 依托单位国家: 美国
• 财政年份: 2014
• 资助国家: 美国
• 起止时间: 2014-07-28 至 2025-05-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10878049
• 关键词: Biodiversity; Biomedical Research; Botanicals; Cardiovascular Diseases; Cementation; Central Asia; Chronic Disease; Collaborations; Community Outreach; Country; Degree requirements; Diabetes Mellitus; Distance Learning; Educational Curriculum; Educational workshop; Ensure; Event; Faculty; Foundations; Funding; Grant; Health; Health Professional; Indonesia; Inflammation; Institution; Interdisciplinary Study; International; Intestinal Diseases; Laboratories; Louisiana; Mentors; Metabolic; Metabolic syndrome; Minority-Serving Institution; Monitor; Pharmacologic Substance; Postdoctoral Fellow; Prevention; Research Training; Resources; Rheumatoid Arthritis; Scientist; Students; Tajikistan; Teacher Professional Development; Testing; Training; Training Programs; Training and Infrastructure; United States National Institutes of Health; Universities; Visit; combat; common treatment; community college; doctoral student; evidence base; experience; nervous system disorder; online course; programs; resilience; symposium; synergism

This renewal will build on a successful research training program carried out in Tajikistan during the last five years. We will leverage accumulated expertise, training materials, networks of international collaborators, and well-developed and tested online and face-to-face training curricula to expand the Tajikistan program and to add Indonesia to the program. Close collaborations between US, Tajik and Indonesian faculty involved in this proposal are well-established and fully functional. The expanded Center for Botanicals and Chronic Diseases (CBCD) will cement and synergize these existing collaborations and provide quality international experience for our trainees. In the next five years, CBCD will focus its training on the evidence-based, rigorous studies of local botanicals for the prevention and treatment of common inflammation-associated chronic diseases and disorders, such as diabetes and metabolic syndrome, cardiovascular diseases, osteo- and rheumatoid arthritis, and intestinal and neurological disorders. CBCD will train 10 scientists in Tajikistan (5 Ph.D. students and 5 postdoctoral fellows) and 24 scientists in Indonesia (16 M.S. and 8 Ph.D. students). Both countries are providing a significant financial match to enable the training. Research training components will include: 1) Online courses and e-workshops; 2) One-on-one e- mentoring and progress monitoring; 3) Annual in-country conferences and workshops with invited international speakers; 4) Visits to mentor's laboratories in the US (funded by Tajikistan for Tajik students); and 5) Required graduate and postdoctoral courses offered in partnering countries. CBCD will involve three U.S. institutions - Rutgers University, Pennington Biomedical Research Center/Louisiana State University, and Eugenio María de Hostos Community College (CUNY), a minority serving institution specializing in health-related training. Internationally, CBCD will involve three leading Tajik institutions and two top-tier Indonesian universities. In addition to its official trainees, CBCD will open its distance learning courses, on-line training and in-country events to a wider audience of local scientists and health professionals, ensuring a broader community outreach. CBCD’s aim is to provide a sustainable foundation for intense research training and retention of local scientists in the interdisciplinary studies of botanicals for the prevention and treatment of chronic diseases. Our integrated training program will leverage resources generated through other NIH-funded programs that involve the research training faculty participating in this proposal: NIH National Center for Botanicals and Metabolic Resiliency (2004 – present); NIH T32 Training Grant in Botanical Approaches to Combat Metabolic Syndrome (just renewed for a 5 year third cycle) and the completed International Cooperative Biodiversity Groups (ICBG) program titled “Building New Pharmaceutical Capabilities in Central Asia.” CBCD will also take advantage of the world-wide research training infrastructure established by the Global Institute for Bioexploration (GIBEX).

这一更新将建立在塔吉克斯坦在过去一年中成功开展的研究培训计划的基础上。 五年我们将利用积累的专业知识、培训材料、国际合作者网络， 开发完善并经过测试的在线和面对面培训课程，以扩大塔吉克斯坦方案， 将印度尼西亚加入该计划。美国，塔吉克和印度尼西亚教师之间的密切合作参与这一 这些建议是完善和完全可行的。扩大的植物药和慢性病中心 （CBCD）将巩固和协同这些现有的合作，并提供优质的国际经验， 我们的实习生在未来五年，CBCD将把培训重点放在基于证据的，严格的地方研究上。 用于预防和治疗常见炎症相关慢性疾病和病症的植物药， 如糖尿病和代谢综合征、心血管疾病、骨关节炎和类风湿性关节炎， 肠道和神经系统疾病。 CBCD将在塔吉克斯坦培训10名科学家（5名博士）。学生和5名博士后研究员）和24名科学家 印度尼西亚（16个硕士学位）8 PhD学生）。这两个国家都提供了重要的财政匹配， 训练研究培训部分将包括：1）在线课程和电子讲习班; 2）一对一的电子 3）邀请国际社会参加年度国内会议和讲习班 演讲者; 4）参观导师在美国的实验室（由塔吉克斯坦为塔吉克斯坦学生提供资金）;以及5）必需 伙伴国家提供的研究生和博士后课程。 CBCD将涉及三个美国机构-罗格斯大学，彭宁顿生物医学研究 中心/路易斯安那州立大学，和Eugenio María de Hoconut社区学院（CUNY），少数服务 专门从事与健康有关的培训的机构。在国际上，CBCD将涉及三个主要的塔吉克斯坦机构 和两所印尼一流大学除了官方培训生外，CBCD还将开放远程学习 为更多的当地科学家和卫生专业人员举办课程、在线培训和国内活动， 确保更广泛的社区推广。 CBCD的目的是为密集的研究培训和保留当地人才提供可持续的基础。 科学家在植物学的跨学科研究，用于预防和治疗慢性疾病。我们 一个综合培训项目将利用其他NIH资助项目产生的资源， 参与这项提案的研究培训教师：NIH国家植物和代谢中心 恢复力（2004年至今）; NIH T32植物学方法治疗代谢综合征培训补助金 (just第三个周期延长5年）和完成的国际生物多样性合作小组（ICBG） 该项目名为“在中亚建立新的制药能力”。CBCD还将利用 全球生物探索研究所（GIBEX）建立的全球研究培训基础设施。

项目成果

Hypolipidemic effect of brown seaweed (Sargassum crassifolium) extract in vivo (Study of histopathology, mRNA expression, and immunohistochemistry (IHC) with VCAM-1, ICAM-1, and MCP-1 parameters).

褐海藻（Sargassum crassifolium）提取物的体内降血脂作用（组织病理学、mRNA 表达和使用 VCAM-1、ICAM-1 和 MCP-1 参数的免疫组织化学 (IHC) 研究）。

• 发表时间: 2024
• 期刊: ArXiv
• 作者: Zaidan,Sarah;Abdillah,Syamsudin;Arfian,Nur;Arozal,Wawaimuli
• 通讯作者: Arozal,Wawaimuli

POLYPHENOLS CONTENT AND ANTIOXIDANT ACTIVITY OF ARTEMISIA SIEVERSIANA WILLD. IN WESTERN PAMIR.

大叶蒿的多酚含量和抗氧化活性。

• 发表时间: 2017
• 期刊: American scientific journal
• 作者: Miravalova,Gulazor;Kurbonbekova,Shifo;Satorov,Shukratdzhon;Mirzorahimov,Akobir;Navruzshoev,Dovudsho;Dushenkov,Vyacheslav;Vakhidova,Manizha
• 通讯作者: Vakhidova,Manizha