COGNITIVE DECLINE IN A PRIMATE MODEL OF CEREBROVASCULAR DISEASE

脑血管疾病灵长类动物模型的认知能力下降

基本信息

  • 批准号:
    6243762
  • 负责人:
  • 金额:
    $ 20.53万
  • 依托单位:
  • 依托单位国家:
    美国
  • 项目类别:
  • 财政年份:
    1996
  • 资助国家:
    美国
  • 起止时间:
    1996-12-01 至 1997-11-30
  • 项目状态:
    已结题

项目摘要

Hypertension, a common condition among the elderly and even middle aged adults, has long been associated with cognitive dysfunction, particularly in the domain of memory. However, the neurobiological basis for this impairments is not well understood. This project will determine the cognitive effects on monkeys at known risk for cerebrovascular disease from hypertension alone, or in combination with an atherogenic diet. We plan to assess the cognitive function of monkeys using behavioral tasks which were developed for, or adapted from neuropsychological batteries used i the evaluation of geriatric populations and, in particular, patients with cerebrovascular disease. The performance of monkeys will be followed in cohorts at six months intervals for either 12 or 48 months. In this matter, a profile of change in cognitive function, including memory, executive function (cognitive flexibility, attention, visuospatial function and psychometric speed) will be determined. We expect to see measurable cognitive impairment, primarily in memory function, occurring as a consequence of hypertension alone, or in combination with atherogenic diet, but not from atherogenic diet alone. This change should be observable by 12 months following induction of hypertension with or without maintenance on atherogenic diet. We expect the long term consequences (48 months) of hypertension to produce a progressive decline in memory function as well as produce impairments in other cognitive domains including executive system function, visuopatial abilities and attention, producing, in effect, a cerebrovascular dementia. We expect that monkeys with hypertension combined with atherogenic diet will also develop a dementia state, but, owing to possible differences in focal neuropathology, the pattern of deficits may be more variable than that found with hypertension alone. The 48 month behavioral assessment of a subset of monkeys in this project will allow us to determine whether early cognitive changes identified at 12 months will progress toward a "dementia" state, as defined by criteria parallel to those for dementia in humans. Furthermore, the changes in cognition charted in this project will be correlated with anatomical, imaging and neuropathological data collected from the same animals to determine the extent of the relationship between these variables. This approach may also permit the identification of a relevant behavioral or neurobiological marker of cognitive impairment and cerebrovascular dementia. Further, a composite index of cognitive decline will be correlated with an overall index of changes on MRI and PET in the same animals. In this manner, we will be able to determine if metabolic hypofunction identified on PET precedes or occurs concomitantly with cognitive impairment. A composite index of behavioral findings as well as changes in individuals domains will be correlated with the presence of blood brain barrier compromise the and extent and pattern of retinopathy. Finally, the relationship between cognitive decline, systolic blood pressure and serum cholesterol level will be measured.
高血压是老年人甚至中年人的常见疾病 成年人,长期以来一直与认知功能障碍有关,特别是 在记忆的领域。 然而,这一现象的神经生物学基础 缺陷还不太清楚。 该项目将决定 对具有已知脑血管疾病风险的猴子的认知影响 单独的高血压,或与致动脉粥样硬化饮食相结合。 我们 计划使用行为任务来评估猴子的认知功能 它们是根据神经心理学电池开发的, 用于老年人群的评价,特别是, 脑血管病患者。 猴子的表演将 在队列中每隔6个月随访12或48 个月 在这个问题上,认知功能的变化, 包括记忆,执行功能(认知灵活性,注意力, 视觉空间功能和心理测量速度)。 我们 预计会出现可测量的认知障碍,主要是在记忆方面 功能,发生作为高血压单独的结果,或在 与致动脉粥样硬化饮食组合,但不是单独来自致动脉粥样硬化饮食。 这种变化应在诱导后12个月内观察到, 高血压伴或不伴维持致动脉粥样硬化饮食。 我们预计 高血压的长期后果(48个月), 记忆功能逐渐衰退, 其他认知领域,包括执行系统功能、视觉 能力和注意力,实际上, 痴呆 我们认为患有高血压的猴子 致动脉粥样硬化饮食也会发展成痴呆状态,但是,由于 局灶性神经病理学的可能差异,缺陷的模式可能 比单独的高血压更易变。 48个月 在这个项目中,对一部分猴子的行为评估将允许 以确定是否在12个月时发现早期认知变化 将进展到“痴呆”状态,如标准平行定义 与人类痴呆症的治疗方法相比较。 此外,认知的变化 在这个项目中绘制的图表将与解剖,成像和 从相同动物收集的神经病理学数据,以确定 这些变量之间的关系。 这种方法可能 还允许识别相关行为或 认知障碍与脑血管病的神经生物学标志物 痴呆 此外,认知能力下降的综合指数将是 与MRI和PET的总体变化指数相关, 动物 通过这种方式,我们将能够确定代谢 PET上识别的功能减退先于或伴随 认知障碍 行为调查结果的综合指数 因为个体域的变化将与 血脑屏障损害的程度和模式 视网膜病变 最后,认知能力下降, 测量收缩压和血清胆固醇水平。

项目成果

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Mark Barry Moss其他文献

Mark Barry Moss的其他文献

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{{ truncateString('Mark Barry Moss', 18)}}的其他基金

The effect of curcumin on age-related cognitive decline in the rhesus monkey
姜黄素对恒河猴年龄相关认知能力下降的影响
  • 批准号:
    8890724
  • 财政年份:
    2013
  • 资助金额:
    $ 20.53万
  • 项目类别:
The effect of curcumin on age-related cognitive decline in the rhesus monkey
姜黄素对恒河猴年龄相关认知能力下降的影响
  • 批准号:
    8720659
  • 财政年份:
    2013
  • 资助金额:
    $ 20.53万
  • 项目类别:
The effect of curcumin on age-related cognitive decline in the rhesus monkey
姜黄素对恒河猴年龄相关认知能力下降的影响
  • 批准号:
    9084446
  • 财政年份:
    2013
  • 资助金额:
    $ 20.53万
  • 项目类别:
The effect of curcumin on age-related cognitive decline in the rhesus monkey
姜黄素对恒河猴年龄相关认知能力下降的影响
  • 批准号:
    9280856
  • 财政年份:
    2013
  • 资助金额:
    $ 20.53万
  • 项目类别:
The effect of curcumin on age-related cognitive decline in the rhesus monkey
姜黄素对恒河猴年龄相关认知能力下降的影响
  • 批准号:
    8578305
  • 财政年份:
    2013
  • 资助金额:
    $ 20.53万
  • 项目类别:
Rehabilitation of Neural Spatial Neglect
神经空间忽视的康复
  • 批准号:
    7103612
  • 财政年份:
    2003
  • 资助金额:
    $ 20.53万
  • 项目类别:
Memory/Executive Systems in Prefrontal & Temporal Cortex
前额叶的记忆/执行系统
  • 批准号:
    7152890
  • 财政年份:
    2003
  • 资助金额:
    $ 20.53万
  • 项目类别:
Memory/Executive Systems in Prefrontal & Temporal Cortex
前额叶的记忆/执行系统
  • 批准号:
    6705383
  • 财政年份:
    2003
  • 资助金额:
    $ 20.53万
  • 项目类别:
Rehabilitation of Neural Spatial Neglect
神经空间忽视的康复
  • 批准号:
    7287810
  • 财政年份:
    2003
  • 资助金额:
    $ 20.53万
  • 项目类别:
Memory/Executive Systems in Prefrontal & Temporal Cortex
前额叶的记忆/执行系统
  • 批准号:
    6828308
  • 财政年份:
    2003
  • 资助金额:
    $ 20.53万
  • 项目类别:

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