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REGULATION OF GABA-A RECEPTOR SUBUNIT EXPRESSION

REGULATION OF GABA-A RECEPTOR SUBUNIT EXPRESSION
GABA-A 受体亚基表达的调控
批准号:
2519864
负责人:
DENNIS R GRAYSON
金额:
$6.45万
依托单位国家:
美国
项目类别:
财政年份:
1993
资助国家:
美国
项目状态:
已结题
起止时间:
1993-09-01 至 1998-08-31

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中文摘要
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英文摘要
In the context of the research proposal, a competitive PCR assay will be used to analyze the profiles of expression of the mRNAs encoding subunits of the GABA-A receptor during development (in vivo) and as cerebellar granule cells differentiate in vitro. This information will be correlated with a comparable in situ hybridization analysis during development in vivo. The hypothesis that cell type specific patterns of expression of the receptor subunit mRNAs are influenced by both heterologous and homologous receptor stimulation will be tested. In the context of, the mechanism by which this trans-synaptic regulation of GABA-A receptor subunit mRNAs occurs will be investigated.
期刊论文(6)
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科研奖励(0)
会议论文
Chronic flumazenil alters GABA(A) receptor subunit mRNA expression, translation product assembly and channel function in neuronal cultures.
慢性氟马西尼会改变神经元培养物中的 GABA(A) 受体亚基 mRNA 表达、翻译产物组装和通道功能。
DOI: --
发表时间: 1996
期刊: The Journal of pharmacology and experimental therapeutics.
影响因子: --
作者: [Zheng,TM, Caruncho,HJ, Zhu,WJ, Vicini,S, Ikonomovic,S, Grayson,DR, Costa,E]
通讯作者: Costa,E
Neonatal capsaicin attenuates mechanical nociception in the rat.
新生儿辣椒素可减弱大鼠的机械伤害感受。
DOI: 10.1016/0304-3940(96)12394-6
发表时间: 1996
期刊: Neuroscience letters
影响因子: 2.5
作者: [Khasar,SG, Levine,JD]
通讯作者: Levine,JD
GABA and NMDA in the prevention of apoptotic-like cell death in vitro.
GABA 和 NMDA 在体外预防细胞凋亡样死亡。
DOI: 10.1016/s0197-0186(96)00159-3
发表时间: 1997
期刊: Neurochemistry international
影响因子: 4.2
作者: [Ikonomovic,S, Kharlamov,E, Manev,H, Ikonomovic,MD, Grayson,DR]
通讯作者: Grayson,DR
Epigenetics Core
  • 批准号:
    10613948
  • 项目类别:
  • 资助金额:
    $26.65万
  • 财政年份:
    2015
  • 负责人:
    DENNIS R GRAYSON
  • 依托单位:
Epigenetics Core
  • 批准号:
    10380647
  • 项目类别:
  • 资助金额:
    $26.71万
  • 财政年份:
    2015
  • 负责人:
    DENNIS R GRAYSON
  • 依托单位:
Regulation of the Reelin Gene
  • 批准号:
    6719046
  • 项目类别:
  • 资助金额:
    $27.28万
  • 财政年份:
    2002
  • 负责人:
    DENNIS R GRAYSON
  • 依托单位:
Regulation of the Reelin Gene
  • 批准号:
    6481449
  • 项目类别:
  • 资助金额:
    $31.17万
  • 财政年份:
    2002
  • 负责人:
    DENNIS R GRAYSON
  • 依托单位:
海外基金