NEUROBIOLOGY OF OPIOID DEPENDENCE

阿片类药物依赖性的神经生物学

• 批准号: 2443372
• 负责人: Marc I Rosen
• 金额: $ 12.18万
• 依托单位: YALE UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 1993
• 资助国家: 美国
• 起止时间: 1993-07-01 至 1999-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/2443372
• 关键词: aminoacid inhibitor; blood chemistry; calcium channel blockers; clinical trials; clonidine; detoxification; drug abuse chemotherapy; drug abuse education; drug screening /evaluation; drug withdrawal; excitatory aminoacid; human subject; human therapy evaluation; naloxone; neurobiology; neuropharmacology; neurotransmitter metabolism; opiate alkaloid; questionnaires

This application is to study excitatory amino acid inputs and calcium- linked neurotransmitter release during opiate withdrawal. The proposed program of research will examine: 1) spontaneous opiate withdrawal in clinical opiate detoxification studies, and 2) naloxone-precipitated opiate withdrawal in a repeated challenge paradigm. The excitatory amino acid contribution to opiate withdrawal will be studied initially with dextromethorphan, a widely used non-opioid antitussive which inhibits excitatory amino acid neurotransmission in pre-clinical studies, and has shown pilot efficacy for treatment of opiate withdrawal. Based on pre- clinical and pilot human studies, the proposed research will determine the anti-withdrawal efficacy of nimodipine, a centrally-acting calcium channel blocker.

本应用程序用于研究兴奋性氨基酸输入和钙离子

项目成果

A pilot study of dextromethorphan in naloxone-precipitated opiate withdrawal.

右美沙芬在纳洛酮促阿片戒断中的初步研究。

• DOI: 10.1016/0014-2999(96)00249-x
• 发表时间: 1996
• 期刊: European journal of pharmacology
• 影响因子: 5
• 作者: Rosen,MI;McMahon,TJ;Woods,SW;Pearsall,HR;Kosten,TR
• 通讯作者: Kosten,TR

The effect of lamotrigine on naloxone-precipitated opiate withdrawal.

拉莫三嗪对纳洛酮促阿片戒断的影响。

• DOI: 10.1016/s0376-8716(98)00057-x
• 发表时间: 1998
• 期刊: Drug and alcohol dependence
• 影响因子: 4.2
• 作者: Rosen,MI;Pearsall,HR;Kosten,TR
• 通讯作者: Kosten,TR

Effect of clonidine pretreatment on naloxone-precipitated opiate withdrawal.

可乐定预处理对纳洛酮促阿片戒断的影响。

• 发表时间: 1996
• 期刊: The Journal of pharmacology and experimental therapeutics.
• 作者: Rosen,MI;McMahon,TJ;Hameedi,FA;Pearsall,HR;Woods,SW;Kreek,MJ;Kosten,TR
• 通讯作者: Kosten,TR