MECHANISTIC STUDY OF PT IV ANTICANCER COMPLEXES

描述：许多铂化合物显示出抗肿瘤特性， 实体瘤 即使是最广泛使用的抗肿瘤铂类药物顺铂， 有很多副作用 某些PtIV复合物药物表现出 毒性更小，并作为前药， 细胞内PtII类。 本申请涉及一种用于制造半导体器件的方法。 PtIV转化为PtII物质的还原化学。 据推测 PtIV复合物的轴向配体可能在以下方面发挥重要作用： 控制该转化的还原化学，从而产生 表现出广泛的细胞毒性的PtII的各种类似物。 崔医生 在本申请中提出通过以下方式来测试该假设的有效性： 研究PtIV化合物的动力学和反应化学， 高效液相色谱、UV/维斯和195 Pt-NMR光谱。

DESCRIPTION: Many Pt compounds show antitumor properties against various solid tumors. Even the most widely used antitumor Pt drug, cisplatin, exhibits many adverse side effects. Certain PtIV - complex drugs exhibit less toxicity and function as prodrugs that are converted into more reactive PtII species intracellularly. The present application deals with the reduction chemistry of ptIV conversion to PtII species. It is hypothesized that the axial ligands of the PtIV complexes may play an important role in controlling the reduction chemistry of this conversion, thereby generating various analogs of PtII that exhibit a wide range of cytotoxicity. Dr. Choi proposes in this application to test the validity of this hypothesis by studying the kinetics and reaction chemistry of PtIV compounds by high performance liquid chromatography, UV/vis and 195Pt-NMR spectroscopy.