DYNAMIC POSTUROGRAPHY AND FAMILIAL HISTORY OF ALCOHOLISM
动态姿势学和酗酒家族史
基本信息
- 批准号:2046511
- 负责人:
- 金额:$ 19.92万
- 依托单位:
- 依托单位国家:美国
- 项目类别:
- 财政年份:1995
- 资助国家:美国
- 起止时间:1995-04-01 至 1999-03-31
- 项目状态:已结题
- 来源:
- 关键词:
项目摘要
Although it has been established that the offspring of alcoholics are
themselves at increased risk for alcoholism, there is a lack of accepted
markers of that risk. The proposed research will investigate the
hypothesis that measures of postural steadiness provide a marker, and in
addition will investigate the specific effects of acute and chronic
alcohol consumption on balance mechanisms. Postural control will be
studied using a dynamic posturography instrument (EquiTest, Neurocom Int.)
which provides for systematic challenges to balance. This instrument will
offer significant advantages over the methods that have been used in prior
studies, which have consisted of measures of static ataxia rather than
dynamic balance control mechanisms. The instrument measures the
contributions of the visual, proprioceptive and vestibular systems to
balance, and also measures motor righting responses elicited by
perturbations of the platform surface. Convergent information regarding
vestibular function will be obtained from a comprehensive battery of
measures of oculomotor function, including positional and gaze nystagmus,
optokinetic response, and pursuit and saccadic movements. Measures of
postural control and eye movements will be studied in four experiments
involving different groups of subjects. Subjects will be drawn from an on-
going study of the genetics of alcoholism (Collaborative Study on the
Genetics of Alcoholism), which provides for systematic ascertainment and
assessment procedures. Experiment 1 will study preadolescent children of
both sexes, with subject groups stratified according to familial density
of alcoholism (and presumed accompanying risk). It is hypothesized that
the children of alcoholics will show balance impairments, due in part to
an over-reliance on visual sensations, and that these impairments will be
in proportion to the familial density of alcoholism. Experiment 2 will
investigate the dose-related effects of acute alcohol on posturographic
and ocular motility measures, in young adult social drinkers. Experiment
3 will investigate the effects of alcohol challenge doses in groups of
nonalcoholic male and female subjects formed on the basis of familial
density of alcoholism and current levels of consumption. It is
hypothesized that alcohol will exacerbate existing balance deficits in the
offspring of alcoholics. Experiment 4 will study abstinent male and female
chronic alcoholics, as a function of familial history, and age-matched
control subjects. It is hypothesized that the postural control abilities
of alcoholics will reflect the combined effects of familial and
consumption histories. In all experiments the measures will yield evidence
regarding the specific mechanisms involved in control of balance and the
effects associated with alcohol.
尽管已经确定酗酒者的后代是
在酒精中毒风险增加的情况下,缺乏被接受的
这是这种风险的标志。拟议的研究将调查
假设姿势稳定性的测量提供了一个标记,并且在
此外,还将调查急性和慢性疾病的具体影响
酒精摄入对平衡机制的影响。体位控制将是
使用动态姿势记录仪(EquiTest,NeUROCOM Int.)进行研究
这为平衡提供了系统性的挑战。这台仪器将会
提供了与以前使用的方法相比的显著优势
研究包括静止性共济失调的测量,而不是
动态平衡控制机制。该仪器测量的是
视觉、本体感觉和前庭系统对
平衡,还测量由以下因素引起的电机回正响应
平台表面的扰动。关于以下方面的融合信息
前庭功能将从一个全面的电池
眼球运动功能的测量,包括位置性和凝视性眼震,
视动反应、追逐和扫视动作。衡量标准
姿势控制和眼球运动将通过四个实验进行研究
涉及不同组的受试者。受试者将从以下位置抽签-
正在进行的酒精中毒遗传学研究(合作研究
酒精中毒的遗传学),它提供了系统的确定和
评估程序。实验1将研究青春期前儿童
两性,受试者组根据家庭密度分层
酗酒(以及推定的伴随风险)。据推测,
酗酒者的孩子会表现出平衡障碍,部分原因是
对视觉的过度依赖,这些损伤将是
与酗酒的家庭密度成正比。实验2将
急性酒精对体位图影响的剂量相关研究
年轻的成年社交饮酒者的眼球运动测量。实验
3将调查酒精挑战剂量对以下人群的影响
非酒精性男性和女性受试者是在家族的基础上形成的
酒精中毒的密度和目前的消费水平。它是
假设酒精会加剧现有的平衡赤字
酗酒者的后代。实验4将研究禁欲的男性和女性
慢性酗酒者,作为家族史的一种功能,并且年龄匹配
控制受试者。据推测,人体的姿势控制能力
对酗酒者的影响将反映出家庭和
消费史。在所有实验中,这些措施都将产生证据
关于控制平衡的具体机制和
与酒精有关的影响。
项目成果
期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
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JOHN W ROHRBAUGH其他文献
JOHN W ROHRBAUGH的其他文献
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{{ truncateString('JOHN W ROHRBAUGH', 18)}}的其他基金
CLOSE ASSOCIATION BETWEEN ALCOHOL AND CIGARETTE USE
饮酒和吸烟之间的密切联系
- 批准号:
6563229 - 财政年份:2002
- 资助金额:
$ 19.92万 - 项目类别:
CLOSE ASSOCIATION BETWEEN ALCOHOL AND CIGARETTE USE
饮酒和吸烟之间的密切联系
- 批准号:
6410025 - 财政年份:2001
- 资助金额:
$ 19.92万 - 项目类别:
CLOSE ASSOCIATION BETWEEN ALCOHOL AND CIGARETTE USE
饮酒和吸烟之间的密切联系
- 批准号:
6299198 - 财政年份:2000
- 资助金额:
$ 19.92万 - 项目类别:
CLOSE ASSOCIATION BETWEEN ALCOHOL AND CIGARETTE USE
饮酒和吸烟之间的密切联系
- 批准号:
6097766 - 财政年份:1999
- 资助金额:
$ 19.92万 - 项目类别:
DYNAMIC POSTUROGRAPHY AND FAMILIAL HISTORY OF ALCOHOLISM
动态姿势学和酗酒家族史
- 批准号:
2389902 - 财政年份:1995
- 资助金额:
$ 19.92万 - 项目类别:
DYNAMIC POSTUROGRAPHY AND FAMILIAL HISTORY OF ALCOHOLISM
动态姿势学和酗酒家族史
- 批准号:
2682980 - 财政年份:1995
- 资助金额:
$ 19.92万 - 项目类别:
DYNAMIC POSTUROGRAPHY AND FAMILIAL HISTORY OF ALCOHOLISM
动态姿势学和酗酒家族史
- 批准号:
2046512 - 财政年份:1995
- 资助金额:
$ 19.92万 - 项目类别: