DOPAMINE D2-RECEPTOR MEDIATED SIGNAL TRANSDUCTION

多巴胺 D2 受体介导的信号转导

基本信息

  • 批准号:
    3414872
  • 负责人:
  • 金额:
    $ 10.57万
  • 依托单位:
  • 依托单位国家:
    美国
  • 项目类别:
  • 财政年份:
    1989
  • 资助国家:
    美国
  • 起止时间:
    1989-08-01 至 1992-07-31
  • 项目状态:
    已结题

项目摘要

The overall goal of this project is to explore signal transduction mechanisms for dopamine acting through D2-receptors, in the belief that this may elucidate the role played by these receptors in regulating neuronal activity. Consequently, the present proposal takes two approaches - first, to establish a model cell system in which dopamine's role in modulating the intracellular second messengers, cAMP and [Ca2+]i can be delineated and secondly, to investigate the electrophysiological consequences of a biochemical perturbation of D2-receptor mediated signal transduction in striatum. The model system to be evaluated will be a neuroblastoma x Chinese hamster embryonic brain explant hybrid cell line (NCB-20), which expresses receptors for dopamine, serotonin, bradykinin, opiates and acetylcholine. The first group of experiments will determine whether D2-receptors inhibit adenylate cyclase in NCB-20 cells and whether these receptors also may perturb [Ca2+]i mobilization in these cells, by measuring D2-receptor effects on phosphatidylinositol metabolism and [Ca2+]i mobilization. In the second group of experiments, conditions will be optimized for the intrastriatal injection of pertussis toxin, so that a significant portion of the pertussis toxin substrates are ADP-ribosylated; a determination will be made on the effectiveness with which this treatment eliminates receptor-mediated inhibition of adenylate cyclase; subsequently, receptor-mediated alterations in electrophysiological properties will be examined in these animals compared to sham-injected controls.
这个项目的总体目标是探索信号转导

项目成果

期刊论文数量(0)
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DERMOT M COOPER其他文献

DERMOT M COOPER的其他文献

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{{ truncateString('DERMOT M COOPER', 18)}}的其他基金

VIDEO RATE CALCIUM IMAGING FACILITY
视频钙成像设备
  • 批准号:
    2777395
  • 财政年份:
    1999
  • 资助金额:
    $ 10.57万
  • 项目类别:
REGULATION OF ADENYLYL CYCLASES BY INTRACELLULAR CALCIUM
细胞内钙对腺苷酸环化酶的调节
  • 批准号:
    2292669
  • 财政年份:
    1997
  • 资助金额:
    $ 10.57万
  • 项目类别:
GTP REGULATORY PROTEINS IN PITUITARY-DERIVED GH3 CELLS
垂体来源的 GH3 细胞中的 GTP 调节蛋白
  • 批准号:
    3023149
  • 财政年份:
    1990
  • 资助金额:
    $ 10.57万
  • 项目类别:
INTRACELLULAR CALCIUM CONTROL OF CAMP SYNTHESIS
CAMP 合成的细胞内钙控制
  • 批准号:
    2266902
  • 财政年份:
    1989
  • 资助金额:
    $ 10.57万
  • 项目类别:
INTRACELLULAR CALCIUM CONTROL OF cAMP SYNTHESIS
坎普合成的细胞内钙控制
  • 批准号:
    6499346
  • 财政年份:
    1989
  • 资助金额:
    $ 10.57万
  • 项目类别:
DOPAMINE D2-RECEPTOR MEDIATED SIGNAL TRANSDUCTION
多巴胺 D2 受体介导的信号转导
  • 批准号:
    3414876
  • 财政年份:
    1989
  • 资助金额:
    $ 10.57万
  • 项目类别:
INTRACELLULAR CALCIUM CONTROL OF CAMP SYNTHESIS
CAMP 合成的细胞内钙控制
  • 批准号:
    2379655
  • 财政年份:
    1989
  • 资助金额:
    $ 10.57万
  • 项目类别:
INTRACELLULAR CALCIUM CONTROL OF CAMP SYNTHESIS
CAMP 合成的细胞内钙控制
  • 批准号:
    2669002
  • 财政年份:
    1989
  • 资助金额:
    $ 10.57万
  • 项目类别:
INTRACELLULAR CALCIUM CONTROL OF cAMP SYNTHESIS
坎普合成的细胞内钙控制
  • 批准号:
    6287086
  • 财政年份:
    1989
  • 资助金额:
    $ 10.57万
  • 项目类别:
INTRACELLULAR CALCIUM CONTROL OF cAMP SYNTHESIS
坎普合成的细胞内钙控制
  • 批准号:
    6629264
  • 财政年份:
    1989
  • 资助金额:
    $ 10.57万
  • 项目类别:

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