SECOND CONFERENCE ON DNA TOPOISOMERASES IN CANCER

第二届癌症 DNA 拓扑异构酶会议

• 批准号: 3434008
• 负责人: MILAN POTMESIL
• 金额: $ 1.4万
• 依托单位: NEW YORK UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 1988
• 资助国家: 美国
• 起止时间: 1988-07-01 至 1989-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/3434008
• 关键词: DNA topoisomerases; antineoplastics; drug metabolism; drug resistance; enzyme inhibitors; meeting /conference /symposium; neoplasm /cancer chemotherapy

We propose to organize the `Second Conference on DNA Topoisomerases in Cancer Chemotherapy', in October 17-19, 1988, at the New York University Medical Center. The preparation and organization of the Conference will include: 1. Dissemination of information regarding the conference by mail and by advertisement or announcements in scientific journals. 2. Organization of the actual conference which will be held as a three day meeting with four plenary sessions of slide presentations, and with two poster sessions. Each slide session will include invited speakers, most of them leading experts in the field, as well as presenters of selected proffered papers. There are four topics of plenary sessions: (i) Genetic studies of topoisomerases; (ii) Topoisomerase I-directed drugs; (iii) Inhibitors of topoisomerase II and mechanism of their action; and (iv) Topoisomerase-related drug resistance. 3. Publication of conference lectures as full-size articles. An attempt will be made to publish the proceedings as a separate issue of the NCI Monographs. The goals of the conference are three-fold: (i) To broaden and update information concerning biology of DNA topoisomerases and the mechanism of inhibition by chemotherapeutic agents; (ii) Once again, to bring together cancer researchers and clinicians interested in the topic, accelerate the transfer of information from basic science into the drug development and clinical studies; and (iii) To assess present advances and discuss future directions in this field. A special effort will be made to include scientists not only from the United States and Canada, but also from abroad.

我们建议组织“第二次DNA拓扑异构酶会议”， 1988年10月17-19日，在纽约， 大学医学中心。 的筹备和组织 会议将包括： 1.通过邮件传播关于会议的信息 以及在科学期刊上刊登广告或公告。 2.会议的实际组织将作为一个 为期三天的会议，包括四次幻灯片全体会议 演讲，并与两个海报会议。 每次幻灯片会议 将包括特邀演讲者，其中大多数是 领域，以及选定的提供论文的主持人。 那里 全体会议的四个专题是：（一）遗传学研究 拓扑异构酶;（ii）拓扑异构酶I导向的药物;（iii） 拓扑异构酶II的抑制剂及其作用机制;以及 (iv)拓扑异构酶相关耐药。 3. 将会议演讲作为全尺寸文章出版。 一个 将尝试将会议记录作为一个单独的问题发表 国家癌症研究所专著的作者 会议的目标有三个方面：㈠扩大和 更新有关DNA拓扑异构酶生物学的信息， 化疗剂的抑制机制;（ii）一旦 再一次，将癌症研究人员和临床医生聚集在一起， 感兴趣的话题，加快信息传递 从基础科学到药物开发和临床研究; 评估目前的进展并讨论未来的方向 在该领域 将作出特别努力， 不仅来自美国和加拿大，也来自国外。