ONTOGENY OF LIMBIC SEIZURES

这项研究旨在检查导致行为的事件 癫痫发作、随后的成熟癫痫状态的发展和 标准抗惊厥药物可能会对这一进化产生影响 一种新开发的部分性癫痫动物模型。部分性癫痫 代表最常见的慢性癫痫，难治性 标准疗法，但对导致 自发性癫痫发作或疾病的自然病史 已经成立了。在这个项目的过程中，以下主题将是 检查过了。 1)第一次行为明显发作之前的事件未知。 有人假设，第一个明显的表现是先于 由一些亚临床脑电发作所致，这些发作在 就像点燃一样的过程。这个问题将通过确定 是否在第一次运动之前出现多次脑电发作 癫痫发作。 2)有一种理论长期以来一直认为癫痫有恶化的趋势 随着时间的推移，虽然也实现了缓解。第二 实验将遵循这种癫痫模型的自然历史 确定癫痫发作频率是否随着随后的癫痫发作而增加。 3)预防性或早期治疗一直是提倡的一种手段 减轻了疾病的严重性，但它的使用是有争议的。这 实验将确定抗惊厥治疗在改变 在前两个实验中建立了癫痫发作的自然病史。 这些实验将检验这些关键问题的个体发育。 使用新的长期监测技术的部分缉获，提供 对导致慢性癫痫状态的机制的新见解。

This study is designed to examine the events leading up to behavioral seizures, the subsequent development of the mature epileptic state and the possible effects standard anticonvulsants may have on this evolution using a newly developed animal model of partial seizures. Partial epilepsy represents the most common chronic seizure disorder which is refractory to standard therapy, but little is known about the mechanisms leading up to spontaneous seizures or about the natural history of the disease once it is established. In the course of this project the following topics will be examined. 1)The events preceding the first behaviorally apparent seizure are unknown. It has been hypothesized that the first overt manifestations are preceded by a number of subclinical electrographic seizures which intensify in a kindling like process. This question will be examined by determining whether a number of electrographic seizures occur before the first motor seizure. 2) One theory has long held that there is a tendency for seizures to worsen over time, although remissions have also been achieved. The second experiment will follow the natural history of this seizure model to determine whether seizure frequency increases with succeeding seizures. 3) Prophylactic or early treatment has been advocated as a means of lessening the severity of the disease, but its use is controversial. This experiment will determine the role of anticonvulsant therapy in changing the natural history of the seizures established in the first 2 experiments. These experiments will examine these critical questions in the ontogeny of partial seizures using the new long term monitoring technology, providing new insights into the mechanisms leading to the chronic epileptic state.