ONTOGENY OF LIMBIC SEIZURES
边缘系统癫痫发作的个体发生
基本信息
- 批准号:3414537
- 负责人:
- 金额:$ 12.82万
- 依托单位:
- 依托单位国家:美国
- 项目类别:
- 财政年份:1990
- 资助国家:美国
- 起止时间:1990-09-25 至 1993-08-31
- 项目状态:已结题
- 来源:
- 关键词:anticonvulsants chronic disease /disorder computer assisted diagnosis disease /disorder model electroencephalography epilepsy hippocampus laboratory rat limbic system longitudinal human study model design /development monitoring device neuroanatomy nonhuman therapy evaluation online computer relapse /recurrence videotape /videodisc
项目摘要
This study is designed to examine the events leading up to behavioral
seizures, the subsequent development of the mature epileptic state and the
possible effects standard anticonvulsants may have on this evolution using
a newly developed animal model of partial seizures. Partial epilepsy
represents the most common chronic seizure disorder which is refractory to
standard therapy, but little is known about the mechanisms leading up to
spontaneous seizures or about the natural history of the disease once it is
established. In the course of this project the following topics will be
examined.
1)The events preceding the first behaviorally apparent seizure are unknown.
It has been hypothesized that the first overt manifestations are preceded
by a number of subclinical electrographic seizures which intensify in a
kindling like process. This question will be examined by determining
whether a number of electrographic seizures occur before the first motor
seizure.
2) One theory has long held that there is a tendency for seizures to worsen
over time, although remissions have also been achieved. The second
experiment will follow the natural history of this seizure model to
determine whether seizure frequency increases with succeeding seizures.
3) Prophylactic or early treatment has been advocated as a means of
lessening the severity of the disease, but its use is controversial. This
experiment will determine the role of anticonvulsant therapy in changing
the natural history of the seizures established in the first 2 experiments.
These experiments will examine these critical questions in the ontogeny of
partial seizures using the new long term monitoring technology, providing
new insights into the mechanisms leading to the chronic epileptic state.
这项研究旨在研究导致行为的事件
癫痫发作,随后发展为成熟的癫痫状态,
标准抗惊厥药可能对这种演变产生的影响,
一种新开发的部分性癫痫发作动物模型。部分性癫痫
代表最常见的慢性癫痫病,
标准疗法,但很少有人知道的机制,
自发性癫痫发作或疾病的自然史,一旦它是
确立了习在这个项目的过程中,将讨论以下主题:
考察
1)第一次行为明显癫痫发作前的事件不详。
据推测,第一个明显的表现之前,
由一些亚临床电图癫痫发作,
像是一个过程。这个问题将通过确定
在第一次运动之前是否发生了多次电图癫痫发作
癫痫。
2)长期以来,有一种理论认为癫痫发作有恶化的趋势
随着时间的推移,虽然也实现了缓解。第二
实验将遵循这种癫痫发作模型的自然历史,
确定癫痫发作频率是否随后续癫痫发作而增加。
3)预防性或早期治疗一直被提倡作为一种手段,
减轻疾病的严重程度,但其使用是有争议的。这
实验将确定抗惊厥治疗的作用,
在前两个实验中建立的癫痫发作的自然史。
这些实验将研究这些关键问题的个体发育,
使用新的长期监测技术部分缉获,
对导致慢性癫痫状态的机制的新见解。
项目成果
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{{ truncateString('EDWARD H BERTRAM', 18)}}的其他基金
Thalamic infusions as a treatment of limbic epilepsy
丘脑输注治疗边缘叶癫痫
- 批准号:
7821361 - 财政年份:2009
- 资助金额:
$ 12.82万 - 项目类别:
Pharmacoresistant limbic epilepsy: model validation
耐药边缘癫痫:模型验证
- 批准号:
6831039 - 财政年份:2004
- 资助金额:
$ 12.82万 - 项目类别:
Pharmacoresistant limbic epilepsy: model validation
耐药边缘癫痫:模型验证
- 批准号:
6931487 - 财政年份:2004
- 资助金额:
$ 12.82万 - 项目类别: