64 Channel EEG Amplifier System

描述（由申请人提供）：本申请是为了替换和扩展弗吉尼亚大学的中央啮齿动物脑电图监测设施。20多年来，该机构在癫痫和癫痫发作研究中发挥了核心作用，并在此期间支持了许多神经科学研究者的努力。许多学生和博士后研究员都将这项技术作为他们培训的一部分。癫痫和癫痫持续状态仍然是美国的一个主要公共卫生问题，通过使用动物模型提供临床相关数据将取得进展。以自发性癫痫发作为特征的啮齿动物癫痫模型的发展为不同类型癫痫的病理生理学提供了许多重要的见解，但记录和量化这些自发性和不可预测的事件限制了这些模型的应用。这些新的啮齿类动物模型的开发和实施已经被同时开发的长期脑电图-视频监控所促进。这项技术最初是为临床开发的，但它已经被修改用于实验室。该应用程序的首席研究员是第一个在多个大鼠中同时开发和使用长时间脑电图记录的人之一，他多年来一直致力于提高易用性并扩大该技术的适用性。现在提交申请是因为急需更换系统。当前系统的硬件已经超过8年了，制造商不再支持它。计算机部件出现故障，关键的替换部件不再可用。该系统可能随时停止运作，从而使NIH资助的一些项目处于危险之中。监测系统的存在和可用性鼓励新的研究人员开发使用脑电图监测的项目，并已被老牌研究人员用于建立新的研究方向。该单元已成为该大学体内啮齿动物神经科学研究的重要设施，必须加以维护。

DESCRIPTION (provided by applicant): This application is to replace and expand a central rodent EEG monitoring facility at the University of Virginia. This facility has had a central role n epilepsy and seizure research for over 20 years and has supported the efforts of a number of neuroscience investigators during that time. Many students and post-doctoral fellows have learned the technique as part of their training. Epilepsy and status epilepticus continue to be a major public health problem in the United States, and progress will be made through the use animal models that provide data that are clinically relevant. The growth of rodent models of epilepsy characterized by spontaneous seizures have provided a number of important insights into the pathophysiology of different types of epilepsy, but documenting and quantifying these spontaneous and unpredictable events limits the application of these models. The development and implementation of these new rodent models has been facilitated by the simultaneous development of long term EEG- video monitoring. This technology was first developed for the clinic, but it has been modified for use in the laboratory. The principal investigator for this application was one of the first to develop and use prolonged EEG recordings in multiple rats simultaneously, and he has worked over the years to improve the ease of use and to broaden the applicability of the technology. The application is submitted now because there is a critical need to replace the system. The current system has hardware that is now over 8 years old, and it is no longer supported by the manufacturer. Computer components are failing and key replacement parts are no longer available. The system could cease to function at any time and thereby place a number of NIH funded projects in jeopardy. The presence and availability of the monitoring system has encouraged new investigators to develop projects that use EEG monitoring and has been used by established investigators to establish new lines of research. The unit has become an essential facility at the University for in vivo rodent neuroscience research, and it must be maintained.