64 Channel EEG Amplifier System

描述(申请人提供)：此申请是为了替换和扩大弗吉尼亚大学的中央啮齿动物脑电监测设施。20多年来，该机构一直在癫痫和癫痫研究中发挥核心作用，并在此期间支持了许多神经科学研究人员的努力。作为培训的一部分，许多学生和博士后研究员已经学习了这项技术。癫痫和癫痫持续状态在美国仍然是一个主要的公共卫生问题，将通过使用提供临床相关数据的动物模型来取得进展。以自发发作为特征的啮齿动物癫痫模型的发展为不同类型癫痫的病理生理学提供了许多重要的见解，但记录和量化这些自发和不可预测的事件限制了这些模型的应用。这些新的啮齿动物模型的开发和实施得益于长期脑电视频监测的同步发展。这项技术最初是为临床开发的，但现已改装用于实验室。这项应用的首席研究员是第一批同时在多只大鼠身上开发和使用延长脑电记录的人之一，多年来他一直在努力提高这项技术的易用性，并扩大该技术的适用性。现在提交申请是因为迫切需要更换该系统。当前系统的硬件已有8年以上的历史，不再受制造商支持。计算机组件出现故障，关键更换部件不再可用。该系统可能在任何时候停止运行，从而使NIH资助的一些项目处于危险之中。监测系统的存在和使用鼓励了新的研究人员开发使用脑电监测的项目，并已被现有的研究人员用来建立新的研究路线。该装置已经成为该大学进行活体啮齿动物神经科学研究的基本设施，必须进行维护。

DESCRIPTION (provided by applicant): This application is to replace and expand a central rodent EEG monitoring facility at the University of Virginia. This facility has had a central role n epilepsy and seizure research for over 20 years and has supported the efforts of a number of neuroscience investigators during that time. Many students and post-doctoral fellows have learned the technique as part of their training. Epilepsy and status epilepticus continue to be a major public health problem in the United States, and progress will be made through the use animal models that provide data that are clinically relevant. The growth of rodent models of epilepsy characterized by spontaneous seizures have provided a number of important insights into the pathophysiology of different types of epilepsy, but documenting and quantifying these spontaneous and unpredictable events limits the application of these models. The development and implementation of these new rodent models has been facilitated by the simultaneous development of long term EEG- video monitoring. This technology was first developed for the clinic, but it has been modified for use in the laboratory. The principal investigator for this application was one of the first to develop and use prolonged EEG recordings in multiple rats simultaneously, and he has worked over the years to improve the ease of use and to broaden the applicability of the technology. The application is submitted now because there is a critical need to replace the system. The current system has hardware that is now over 8 years old, and it is no longer supported by the manufacturer. Computer components are failing and key replacement parts are no longer available. The system could cease to function at any time and thereby place a number of NIH funded projects in jeopardy. The presence and availability of the monitoring system has encouraged new investigators to develop projects that use EEG monitoring and has been used by established investigators to establish new lines of research. The unit has become an essential facility at the University for in vivo rodent neuroscience research, and it must be maintained.