64 Channel EEG Amplifier System

描述（由申请人提供）：本申请旨在替换和扩展弗吉尼亚大学的中央啮齿动物EEG监测设施。该设施在癫痫和癫痫发作研究中发挥了核心作用超过20年，并在此期间支持了许多神经科学研究人员的努力。许多学生和博士后研究员已经学习了这项技术作为他们培训的一部分。癫痫和癫痫持续状态仍然是美国的一个主要公共卫生问题，通过使用提供临床相关数据的动物模型将取得进展。以自发性癫痫发作为特征的啮齿动物癫痫模型的发展为不同类型癫痫的病理生理学提供了许多重要的见解，但记录和量化这些自发和不可预测的事件限制了这些模型的应用。这些新的啮齿动物模型的开发和实施已经通过长期EEG视频监测的同时开发而得到促进。这项技术最初是为临床开发的，但它已被修改用于实验室。该应用的主要研究者是最早在多只大鼠中同时开发和使用长时间EEG记录的人之一，多年来他一直致力于提高易用性并扩大该技术的适用性。现在提交申请是因为迫切需要更换该系统。当前系统的硬件已经使用8年以上，制造商不再支持。计算机组件出现故障，关键的更换部件不再可用。该系统可能会在任何时候停止运作，从而使一些NIH资助的项目处于危险之中。监测系统的存在和可用性鼓励了新的研究人员开发使用EEG监测的项目，并已被现有的研究人员用于建立新的研究路线。该单位已成为在体内啮齿动物神经科学研究的大学的一个必不可少的设施，它必须得到维护。

DESCRIPTION (provided by applicant): This application is to replace and expand a central rodent EEG monitoring facility at the University of Virginia. This facility has had a central role n epilepsy and seizure research for over 20 years and has supported the efforts of a number of neuroscience investigators during that time. Many students and post-doctoral fellows have learned the technique as part of their training. Epilepsy and status epilepticus continue to be a major public health problem in the United States, and progress will be made through the use animal models that provide data that are clinically relevant. The growth of rodent models of epilepsy characterized by spontaneous seizures have provided a number of important insights into the pathophysiology of different types of epilepsy, but documenting and quantifying these spontaneous and unpredictable events limits the application of these models. The development and implementation of these new rodent models has been facilitated by the simultaneous development of long term EEG- video monitoring. This technology was first developed for the clinic, but it has been modified for use in the laboratory. The principal investigator for this application was one of the first to develop and use prolonged EEG recordings in multiple rats simultaneously, and he has worked over the years to improve the ease of use and to broaden the applicability of the technology. The application is submitted now because there is a critical need to replace the system. The current system has hardware that is now over 8 years old, and it is no longer supported by the manufacturer. Computer components are failing and key replacement parts are no longer available. The system could cease to function at any time and thereby place a number of NIH funded projects in jeopardy. The presence and availability of the monitoring system has encouraged new investigators to develop projects that use EEG monitoring and has been used by established investigators to establish new lines of research. The unit has become an essential facility at the University for in vivo rodent neuroscience research, and it must be maintained.