CONFERENCE: ANTIGEN AND CLONE-SPECIFIC IMMUNOREGULATION

会议：抗原和克隆特异性免疫调节

• 批准号: 3433582
• 负责人: RICHARD Leslie EDELSON
• 金额: $ 1.85万
• 依托单位: NEW YORK ACADEMY OF SCIENCES
• 依托单位国家: 美国
• 财政年份: 1990
• 资助国家: 美国
• 起止时间: 1990-09-01 至 1991-06-20
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/3433582
• 关键词: immunopathology; immunoregulation; meeting /conference /symposium; travel

In the normal, homeostatic situation, the immune system regulates its own activity with exquisite sensitivity. However, a disordered immune response initiates and perpetuates a large number of serious pathological conditions, ranging from lymphocytic neoplasms to autoimmune disorders. In contrast to the efficient, clone-specific manner in which the normal immune system regulates itself, standard methods of treating these immunopathological states have employed immunosuppressive reagents to ablate the immune response altogether. Whereas this approach has been of tremendous benefit in particular instances of autoimmunes disease or graft rejection, its applicability is limited by the very real dangers of crippling an immune system required for the maintenance of the integrity of the individual. More recently, based upon an evolving understanding of basic immunology, investigators using a wide variety of approaches have developed model systems, and even patient applications, that utilize reagents and/or methodologies that successfully result in modulation of the immune response in an antigen-specific and/or clone-specific fashion. In situations ranging from the induction of antigen-specific T cell tolerance in vitro to the generation of specific anti-tumor T cell responses in vivo, highly selective approaches are being developed. Such approaches are quite attractive with respect to the development of new treatments of diseases of the immune system, since they have the potential of leaving responses to most independent antigens unperturbed. The should attract participants and an audience representing a wide range of interests and expertise. Its purpose is to bring together individuals whose work bears on the topic of antigen- and clone specific modulation of immune function, with an emphasis on the diversity of the experimental approaches and systems used. It is expected that the interaction between basic scientists, clinical researches and clinicians will promote new approaches to the directed therapy of disorders whose pathogenesis includes inappropriate immune responses.

在正常的，稳态的情况下，免疫系统调节自己的 活动与精致的灵敏度。 然而，一种紊乱的免疫反应 引发并延续了大量严重的病理性 疾病，从淋巴细胞肿瘤到自身免疫性疾病。 在 与正常免疫细胞以高效的克隆特异性方式 系统自我调节，治疗这些疾病的标准方法 免疫病理状态已经使用免疫抑制试剂 完全消除免疫反应。 虽然这种方法已经 在自身免疫性疾病或移植物的特定情况下， 拒绝，它的适用性是有限的非常真实的危险， 破坏了维持人体免疫系统的完整性 个人 最近，基于对 基础免疫学，研究人员使用各种方法， 开发的模型系统，甚至是患者应用程序， 试剂和/或方法，其成功地导致调节 以抗原特异性和/或克隆特异性方式产生免疫应答。 在 从诱导抗原特异性T细胞耐受 体外产生特异性抗肿瘤T细胞应答， 正在开发高度选择性的方法。 这些方法相当 在开发新的疾病治疗方法方面具有吸引力， 免疫系统，因为它们有可能留下反应， 大多数独立抗原未受干扰。 应吸引与会者， 代表广泛兴趣和专业知识的听众。 其 目的是汇集个人的工作承担的主题， 免疫功能的抗原和克隆特异性调节， 所使用的实验方法和系统的多样性。 是 希望基础科学家、临床研究 临床医生将促进新的方法来定向治疗， 发病机制包括不适当的免疫反应的疾病。