Mechanisms Of HIV-1 Entry and Transfer to CD4+ T cells via DC-SIGN

HIV-1 通过 DC-SIGN 进入并转移至 CD4 T 细胞的机制

• 批准号: 7732762
• 负责人: Gary J Nabel
• 金额: $ 59.25万
• 依托单位: NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES
• 依托单位国家: 美国
• 资助国家: 美国
• 起止时间: 至
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/7732762
• 关键词: Binding; Biological; Biological Process; CD4 Positive T Lymphocytes; Cell Death; Complex; Dendritic Cells; Goals; HIV Infections; HIV-1; Laboratories; Molecular; NF-kappa B; Pathway interactions; Play; Role; Surface; T-Lymphocyte; Transcriptional Regulation; Viral Proteins; Virus Diseases; base; insight; receptor; research study; therapeutic target

The function and biological activities of the HIV-1 Viral Protein R (Vpr)are being studied at the molecular and cellular levels. During the past year, the laboratory identified a cellular complex to which Vpr binds, and it was determined that this complex plays an essential role in Vpr's biological activities. These findings will be used as a basis for further T cells experiments in the context of viral infection, especially with regard to HIV-1 induced cell death and as a potentially therapeutic target.

HIV-1病毒蛋白R （Vpr）的功能和生物学活性正在分子和细胞水平上进行研究。在过去的一年里，实验室发现了Vpr结合的细胞复合体，并确定该复合体在Vpr的生物活性中起着重要作用。这些发现将作为进一步在病毒感染背景下进行T细胞实验的基础，特别是关于HIV-1诱导的细胞死亡，并作为潜在的治疗靶点。