课题基金 / 基金详情

Mechanisms Of HIV-1 Entry and Transfer to CD4+ T cells via DC-SIGN

Mechanisms Of HIV-1 Entry and Transfer to CD4+ T cells via DC-SIGN
HIV-1 通过 DC-SIGN 进入并转移至 CD4 T 细胞的机制
批准号：
7732762
负责人：
Gary J Nabel
金额：
$59.25万
依托单位：
NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES
依托单位国家：
美国
项目类别：
财政年份：
--
资助国家：
美国
项目状态：
未结题
起止时间：
至
来源：
https://reporter.nih.gov/project-details/7732762
关键词：
BindingBiologicalBiological ProcessCD4 Positive T LymphocytesCell DeathComplexDendritic CellsGoalsHIV InfectionsHIV-1LaboratoriesMolecularNF-kappa BPathway interactionsPlayRoleSurfaceT-LymphocyteTranscriptional RegulationViral ProteinsVirus Diseasesbaseinsightreceptorresearch studytherapeutic target

项目摘要

项目成果

Gary J Nabel的其他基金

相似基金

相关文献

中文摘要
翻译
HIV-1病毒蛋白R(VPR)的功能和生物活性正被从分子和细胞水平进行研究。在过去的一年里，实验室发现了VPR结合的细胞复合体，并确定该复合体在VPR的生物学活性中发挥着重要作用。这些发现将被用作进一步在病毒感染的背景下进行T细胞实验的基础，特别是关于艾滋病毒-1诱导的细胞死亡的实验，并作为潜在的治疗靶点。
英文摘要
The function and biological activities of the HIV-1 Viral Protein R (Vpr)are being studied at the molecular and cellular levels. During the past year, the laboratory identified a cellular complex to which Vpr binds, and it was determined that this complex plays an essential role in Vpr's biological activities. These findings will be used as a basis for further T cells experiments in the context of viral infection, especially with regard to HIV-1 induced cell death and as a potentially therapeutic target.
期刊论文(1)
专著(0)
科研奖励(0)
会议论文
CORE--VECTOR CONSTRUCTION
CORE--QUANTITATIVE MOLECULAR ANALYSIS
COMBINATION GENE TRANSFER, ANTIVIRAL TREATMENT & IMMUNOSTIMULATION FOR HIV+
IMMUNOTHERAPY BY IN VIVO GENE TRANSFER INTO TUMORS
海外基金