SEARCH-CKD: The nature of chronic kidney disease and elevated blood pressure in sub-Saharan Africa.

SEARCH-CKD：撒哈拉以南非洲地区慢性肾病和血压升高的本质。

• 批准号: 10618367
• 负责人: Anthony N Muiru
• 金额: $ 19.99万
• 依托单位: UNIVERSITY OF CALIFORNIA, SAN FRANCISCO
• 依托单位国家: 美国
• 财政年份: 2021
• 资助国家: 美国
• 起止时间: 2021-07-01 至 2026-03-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10618367
• 关键词: Acceleration; Address; Africa; Africa South of the Sahara; African; African ancestry; Biological Markers; Biostatistical Methods; Blood Pressure; Certification; Chronic; Chronic Kidney Failure; Clinical Research; Collection; Community Health; Cross-Sectional Studies; Development; Diabetes Mellitus; Disease; Disease Progression; Enrollment; Environmental Epidemiology; Epidemiologic Methods; Epidemiology; Etiology; Fellowship; Foundations; Functional disorder; Geographic Distribution; Glomerular Filtration Rate; Goals; HIV Infections; HIV Seropositivity; Health Policy; Hematuria; High Prevalence; Hour; Household; Human immunodeficiency virus test; Hypertension; Individual; Inflammation; Infrastructure; Injury; Kenya; Kidney; Kidney Diseases; Knowledge; Longitudinal cohort; Longitudinal cohort study; Measurement; Measures; Mentored Patient-Oriented Research Career Development Award; Mentors; Mentorship; Nature; Nitrites; Nocturnal Hypertension; Participant; Pathogenesis; Patients; Persons; Pesticides; Phenotype; Pollution; Population; Prevalence; Proteinuria; Public Health; Renal function; Research; Research Infrastructure; Research Personnel; Resource-limited setting; Risk Factors; Rural; Rural Community; Sampling; Source; Specialist; Standardization; Time; Traditional Medicine; Training; Tubular formation; Uganda; Urine; Visit; Work; biomass fuel; blood pressure elevation; burden of illness; career; clinical investigation; clinically significant; community health study; cooking; drinking water; experience; follow-up; geographic difference; insight; masked hypertension; multidisciplinary; nephrotoxicity; patient oriented; pesticide exposure; regional difference; skills; urinary; white coat hypertension

PROJECT SUMMARY/ABSTRACT: Through this K23 award, Dr. Anthony Muiru will obtain the knowledge, skills, and expertise necessary to become a leading investigator in patient-oriented clinical research of chronic kidney disease (CKD) and elevated blood pressure (BP) among people of recent African ancestry. During his renal fellowship, he leveraged the infrastructure of the Sustainable East Africa Research in Community Health (SEARCH) study to define the epidemiology of CKD in rural East Africa. He established the SEARCH-CKD study, comprising a representative sample of 3,686 SEARCH participants from rural Uganda and Kenya. Key findings from initial work in SEARCH-CKD included: 1) High prevalence of unexplained leukocyturia and hematuria; 2) a striking geographic variation in CKD prevalence; and 3) high prevalence of elevated BP among individuals with CKD. Dr. Muiru intends to follow up on these initial SEARCH-CKD findings to achieve the following goals: 1) transform SEARCH-CKD from a cross-sectional study into a longitudinal cohort study; 2) gain hands-on experience in longitudinal cohort management, collection of bio-samples and subsequent measurement of analytes; 3) acquire expertise in advanced epidemiological and biostatistical methods, environmental epidemiology; and 4) obtain certification as a hypertension specialist. To achieve these goals, Dr. Muiru has assembled a multidisciplinary team of mentors and advisors, he will enroll in a customized selection of courses, and will continue to leverage the infrastructure established by the SEARCH study. CKD leads to elevated BP and elevated BP in turn accelerates CKD progression. The burden of these two conditions is growing dramatically in sub-Saharan Africa. This K23 award will allow Dr. Muiru to address key knowledge gaps in regard to CKD and elevated BP in rural East Africa and provide him with the support and mentorship necessary to accomplish the following aims: 1) determine the significance of leukocyturia and hematuria observed among individuals living in rural East Africa; 2) examine potential risk factors for CKD that may explain the geographic variation in CKD prevalence in rural East Africa, 3) define BP phenotypes among participants with CKD (~half HIV-positive) by obtaining standardized single time-point BP measurement followed by 24-hr ambulatory blood pressure measurement. This proposal will provide Dr. Muiru with an invaluable training platform that will propel him into an independent research career. In addition, the proposed research will advance our understanding of kidney disease and elevated BP among people of recent African ancestry.

项目摘要/摘要：通过这个K23奖项，Anthony Muiru博士将获得知识， 成为以患者为中心的慢性阻塞性肺疾病临床研究的领先者所需的技能和专业知识 最近的非洲血统人群中的肾脏疾病(CKD)和高血压(BP)。在他的 肾脏奖学金，他利用了可持续东非社区卫生研究的基础设施 (Search)确定东非农村慢性病流行病学的研究。他建立了搜索-CKD 这项研究由来自乌干达和肯尼亚农村的3686名具有代表性的搜索参与者组成。钥匙 Search-CKD初步工作的发现包括：1)不明原因白细胞尿症的高患病率和 血尿；2)慢性肾脏病患病率的显著地理差异；以及3)高血压的高患病率。 患有慢性肾脏病的个体。Muiru博士打算跟进这些初步的搜索-CKD发现，以实现 以下目标：1)将SEARCH-CKD从横断面研究转变为纵向队列研究；2) 在纵向队列管理、生物样本收集和后续工作中获得实践经验 分析物的测量；3)掌握先进的流行病学和生物统计学方法的专业知识， 环境流行病学；以及4)获得高血压专家认证。为了实现这些目标， 米鲁博士已经组建了一个由导师和顾问组成的多学科团队，他将注册一个定制的 将继续利用搜索研究建立的基础设施。 慢性肾脏病导致血压升高，而血压升高反过来又加速慢性肾脏病的进展。这两个人的负担 撒哈拉以南非洲的情况正在戏剧性地增长。这个K23奖项将允许Muiru博士在Key 关于慢性肾脏病和东非农村地区血压升高的知识差距，并为他提供支持和 完成以下目标所需的指导：1)确定白细胞尿和 在生活在东非农村的个人中观察到的血尿；2)检查CKD的潜在危险因素 可以解释东非农村CKD患病率的地理差异，3)确定以下BP表型 CKD(~一半HIV阳性)患者通过获得标准化的单时间点血压测量 随后进行24小时动态血压测量。这项提议将为Muiru博士提供 无价的培训平台，将推动他进入独立的研究生涯。此外，建议的 研究将促进我们对肾脏疾病和新近非洲人血压升高的理解 血统。