Integrated Membrane Program (IMP)

综合膜计划（IMP）

• 批准号: 10618904
• 负责人: Todd B Reynolds
• 金额: $ 31.83万
• 依托单位: UNIVERSITY OF TENNESSEE KNOXVILLE
• 依托单位国家: 美国
• 财政年份: 2021
• 资助国家: 美国
• 起止时间: 2021-07-01 至 2026-06-30
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10618904
• 关键词: Membrane; programs

Project Summary The Integrated Membrane Program (IMP) T32 Training Grant will address an important gap that exists in the biomedical workforce of the future. The IMP will address research training needs in the area of biological membranes (biomembranes), which are crucially important structures that define and separate physical spaces within and outside cells, making them fundamental to life on Earth. However, biomembranes do much more, as they control intracellular signaling and development, are required for energy production, mediate drug delivery and drug resistance, are essential for making essential cellular macromolecules, and affect growth and movement, which impacts cancer and other diseases. Thus, understanding biomembranes impacts many critical areas of biomedical research. Biomembranes research as a field covers the mechanisms by which membranes are synthesized from their constituent proteins, lipids, and carbohydrates, are trafficked and changed in response to the environment, and then in turn affect the many processes described above. Additionally, human manipulation of natural and synthetic membranes can be harnessed for myriad applications from computation to energy production to the development of new materials. Multiple fields and disciplines including biology, physics, chemistry, engineering, and computational science have applicability to biomembranes, but increasingly, there is a need for scientists who can bridge these fields and integrate different approaches to meet the next generation of research challenges. The University of Tennessee, Knoxville (UT) has unique breadth and depth in biomembrane research, with federally funded, collaborative researchers spanning 7 departments in 4 colleges. The 32 faculty in the IMP mentor pool have a shared commitment to establish a training program that will span fields and disciplines. These scientists are already working together through the establishment of the UT- facilitated Community of Scholars (COS) for Biomembranes, which has met 2-3 times every semester since 2018, and where many students have presented seminars on their research. The shared research, training, and overall momentum that exists within the Biomembranes COS forms the foundation for the IMP T32. Multiple investigators within the Biomembranes COS have ongoing collaborations that span fields and disciplines, and have co-mentored graduate students. The establishment of a T32-based IMP will formalize this integrated approach to training so these students can advance fundamental knowledge of biomembranes and apply this knowledge to improve human health. In addition to integrated training in science, the IMP will further enhance training in responsible conduct of research, reproducibility, and diversity and inclusion, which are already being addressed at UT, but will be formalized under this NIH T32 mechanism.

项目摘要 综合膜计划(IMP)T32培训补助金将解决存在于 未来的生物医学劳动力。该项目将解决生物学领域的研究培训需求。 膜(生物膜)，这是定义和分隔物理空间的至关重要的结构 细胞内和细胞外，使它们成为地球上生命的基础。然而，生物膜的作用要大得多，因为 它们控制着细胞内的信号和发育，是产生能量、调节药物传递所必需的 和抗药性，是制造必要的细胞大分子所必需的，并影响生长和 运动，这会影响癌症和其他疾病。因此，了解生物膜对许多关键的 生物医学研究领域。生物膜作为一个领域的研究涵盖了膜的作用机制 是由它们的组成蛋白质、脂肪和碳水化合物合成的，它们被运输和改变作为回应 对环境的影响，然后反过来影响上述许多过程。此外，人类 天然膜和合成膜的操纵可用于从计算到 能源生产向新材料的发展迈进。多个领域和学科，包括生物、物理、 化学、工程和计算科学都适用于生物膜，但越来越多地， 是对能够连接这些领域并整合不同方法以满足下一代需求的科学家的需求 研究挑战。田纳西大学诺克斯维尔分校(UT)拥有独特的广度和深度 生物膜研究，由联邦政府资助，合作研究人员横跨4所学院的7个系。 IMP导师库中的32名教职员工共同致力于建立一个将跨越 领域和学科。这些科学家已经在通过建立UT而合作- 促进生物膜学者社区(COS)，此后每学期召开2-3次会议 2018年，许多学生在那里举办了关于他们的研究的研讨会。共享的研究、培训和 总体而言，生物膜COS中存在的动量构成了IMP T32的基础。多重 生物膜COS内的研究人员正在进行跨领域和学科的合作，以及 共同指导过研究生。建立一个基于T32的IMP将使这一综合计划正规化 培训方法，以便这些学生能够提高生物膜的基础知识并应用 改善人类健康的知识。除了科学综合培训外，IMP还将进一步加强 负责任地进行研究、可再现性以及多样性和包容性方面的培训，这些已经在 在德克萨斯州解决，但将在此NIH T32机制下正式确定。

项目成果

Activation of Cph1 causes ß(1,3)-glucan unmasking in Candida albicans and attenuates virulence in mice in a neutrophil-dependent manner.

• DOI: 10.1371/journal.ppat.1009839
• 发表时间: 2021-08
• 期刊: PLoS pathogens
• 影响因子: 6.7
• 作者: Wagner AS;Hancock TJ;Lumsdaine SW;Kauffman SJ;Mangrum MM;Phillips EK;Sparer TE;Reynolds TB
• 通讯作者: Reynolds TB

PEGylated nanoparticles interact with macrophages independently of immune response factors and trigger a non-phagocytic, low-inflammatory response.

聚乙二醇化纳米粒子与巨噬细胞相互作用，独立于免疫反应因子，并引发非吞噬性、低炎症反应。

• DOI: 10.1016/j.jconrel.2023.12.019
• 发表时间: 2024
• 期刊: Journal of controlled release : official journal of the Controlled Release Society
• 作者: Asoudeh,Monireh;Nguyen,Nicole;Raith,Mitch;Denman,DesireeS;Anozie,UcheC;Mokhtarnejad,Mahshid;Khomami,Bamin;Skotty,KaitlynM;Isaac,Sami;Gebhart,Taylor;Vaigneur,Lauren;Gelgie,Aga;Dego,OudessaKerro;Freeman,Trevor;Beever,Jon;Da
• 通讯作者: Da

Cek1 regulates ß(1,3)-glucan exposure through calcineurin effectors in Candida albicans.

• DOI: 10.1371/journal.pgen.1010405
• 发表时间: 2022-09
• 期刊: PLoS genetics
• 影响因子: 4.5

Complete Genome Sequence of Pseudomonas sp. Strain 273, a Haloalkane-Degrading Bacterium.

• DOI: 10.1128/mra.00176-23
• 发表时间: 2023-07-18
• 期刊: Microbiology resource announcements
• 影响因子: 0.8

Challenges and the Evolving Landscape of Assessing Blood-Based PD-L1 Expression as a Biomarker for Anti-PD-(L)1 Immunotherapy.

• DOI: 10.3390/biomedicines10051181
• 发表时间: 2022-05-20
• 期刊: Biomedicines
• 影响因子: 4.7