Integrated Membrane Program (IMP)

综合膜计划（IMP）

• 批准号: 10618904
• 负责人: Todd B Reynolds
• 金额: $ 31.83万
• 依托单位: UNIVERSITY OF TENNESSEE KNOXVILLE
• 依托单位国家: 美国
• 财政年份: 2021
• 资助国家: 美国
• 起止时间: 2021-07-01 至 2026-06-30
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10618904
• 关键词: Membrane; programs

Project Summary The Integrated Membrane Program (IMP) T32 Training Grant will address an important gap that exists in the biomedical workforce of the future. The IMP will address research training needs in the area of biological membranes (biomembranes), which are crucially important structures that define and separate physical spaces within and outside cells, making them fundamental to life on Earth. However, biomembranes do much more, as they control intracellular signaling and development, are required for energy production, mediate drug delivery and drug resistance, are essential for making essential cellular macromolecules, and affect growth and movement, which impacts cancer and other diseases. Thus, understanding biomembranes impacts many critical areas of biomedical research. Biomembranes research as a field covers the mechanisms by which membranes are synthesized from their constituent proteins, lipids, and carbohydrates, are trafficked and changed in response to the environment, and then in turn affect the many processes described above. Additionally, human manipulation of natural and synthetic membranes can be harnessed for myriad applications from computation to energy production to the development of new materials. Multiple fields and disciplines including biology, physics, chemistry, engineering, and computational science have applicability to biomembranes, but increasingly, there is a need for scientists who can bridge these fields and integrate different approaches to meet the next generation of research challenges. The University of Tennessee, Knoxville (UT) has unique breadth and depth in biomembrane research, with federally funded, collaborative researchers spanning 7 departments in 4 colleges. The 32 faculty in the IMP mentor pool have a shared commitment to establish a training program that will span fields and disciplines. These scientists are already working together through the establishment of the UT- facilitated Community of Scholars (COS) for Biomembranes, which has met 2-3 times every semester since 2018, and where many students have presented seminars on their research. The shared research, training, and overall momentum that exists within the Biomembranes COS forms the foundation for the IMP T32. Multiple investigators within the Biomembranes COS have ongoing collaborations that span fields and disciplines, and have co-mentored graduate students. The establishment of a T32-based IMP will formalize this integrated approach to training so these students can advance fundamental knowledge of biomembranes and apply this knowledge to improve human health. In addition to integrated training in science, the IMP will further enhance training in responsible conduct of research, reproducibility, and diversity and inclusion, which are already being addressed at UT, but will be formalized under this NIH T32 mechanism.

项目摘要 综合膜计划（IMP）T32培训补助金将解决存在的一个重要差距， 未来的生物医学劳动力国际执行方案将满足生物技术领域的研究培训需要， 膜（生物膜），这是至关重要的结构，定义和分离的物理空间 在细胞内外，使它们成为地球上生命的基础。然而，生物膜做得更多， 它们控制细胞内信号传导和发育，是能量产生所必需的，介导药物递送 和耐药性，对于制造必需的细胞大分子至关重要，并影响生长和 运动，影响癌症和其他疾病。因此，了解生物膜会影响许多关键的 生物医学研究领域。生物膜研究作为一个领域涵盖的机制， 由其组成蛋白质、脂质和碳水化合物合成，并被运输和响应改变 环境，然后反过来影响上述许多过程。此外，人类 天然和合成膜的操纵可以用于从计算到 能源生产到新材料的开发。多个领域和学科，包括生物学，物理学， 化学、工程学和计算科学都适用于生物膜，但越来越多的是， 需要科学家能够在这些领域之间架起桥梁，整合不同的方法，以满足下一代的需求。 的研究挑战。田纳西大学，诺克斯维尔（UT）具有独特的广度和深度， 生物膜研究，与联邦政府资助，合作研究人员跨越7个部门在4所大学。 IMP导师库中的32名教师共同承诺建立一个培训计划， 领域和学科。这些科学家已经通过建立UT- 促进生物膜学者社区（COS），自成立以来，每学期举行2-3次会议 2018年，在那里许多学生提出了他们的研究研讨会。共享的研究、培训和 存在于生物膜COS中的整体动量形成了IMP T32的基础。多 生物膜COS的研究人员正在进行跨领域和学科的合作， 共同指导研究生。建立一个基于T32的国际执行计划将正式确定这一一体化的 培训的方法，使这些学生可以推进生物膜的基础知识，并应用这一点， 增进人类健康的知识。除了科学方面的综合培训外，IMP还将进一步加强 在负责任的研究行为、可重复性、多样性和包容性方面进行培训，这些培训已经在 在UT解决，但将在NIH T32机制下正式化。

项目成果

Activation of Cph1 causes ß(1,3)-glucan unmasking in Candida albicans and attenuates virulence in mice in a neutrophil-dependent manner.

• DOI: 10.1371/journal.ppat.1009839
• 发表时间: 2021-08
• 期刊: PLoS pathogens
• 影响因子: 6.7
• 作者: Wagner AS;Hancock TJ;Lumsdaine SW;Kauffman SJ;Mangrum MM;Phillips EK;Sparer TE;Reynolds TB
• 通讯作者: Reynolds TB

PEGylated nanoparticles interact with macrophages independently of immune response factors and trigger a non-phagocytic, low-inflammatory response.

聚乙二醇化纳米粒子与巨噬细胞相互作用，独立于免疫反应因子，并引发非吞噬性、低炎症反应。

• DOI: 10.1016/j.jconrel.2023.12.019
• 发表时间: 2024
• 期刊: Journal of controlled release : official journal of the Controlled Release Society
• 作者: Asoudeh,Monireh;Nguyen,Nicole;Raith,Mitch;Denman,DesireeS;Anozie,UcheC;Mokhtarnejad,Mahshid;Khomami,Bamin;Skotty,KaitlynM;Isaac,Sami;Gebhart,Taylor;Vaigneur,Lauren;Gelgie,Aga;Dego,OudessaKerro;Freeman,Trevor;Beever,Jon;Da
• 通讯作者: Da

Cek1 regulates ß(1,3)-glucan exposure through calcineurin effectors in Candida albicans.

• DOI: 10.1371/journal.pgen.1010405
• 发表时间: 2022-09
• 期刊: PLoS genetics
• 影响因子: 4.5

Ginsenoside Rc from Panax Ginseng Ameliorates Palmitate-Induced UB/OC-2 Cochlear Cell Injury.

• DOI: 10.3390/ijms24087345
• 发表时间: 2023-04-16
• 期刊: INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
• 影响因子: 5.6
• 作者: Gill, Nicholas B. B.;Dowker-Key, Presley D. D.;Hubbard, Katelin;Voy, Brynn H. H.;Whelan, Jay;Hedrick, Mark;Bettaieb, Ahmed
• 通讯作者: Bettaieb, Ahmed

Complete Genome Sequence of Pseudomonas sp. Strain 273, a Haloalkane-Degrading Bacterium.

• DOI: 10.1128/mra.00176-23
• 发表时间: 2023-07-18
• 期刊: Microbiology resource announcements
• 影响因子: 0.8