Effect Of Intra-aortic Balloon Pump In A Canine Model Of Septic Shock

主动脉内球囊泵在感染性休克犬模型中的作用

• 批准号: 7733555
• 负责人: Michael A Solomon
• 金额: $ 7.56万
• 依托单位: CLINICAL CENTER
• 依托单位国家: 美国
• 资助国家: 美国
• 起止时间: 至
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/7733555
• 关键词: Animal Model; Blood flow; Canis familiaris; Cause of Death; Coronary; Counterpulsation; Critical Care; Data; Dependence; Diastole; Heart; Intensive Care Units; Intra-Aortic Balloon Pumping; Left; Low Cardiac Output; Manuscripts; Medical; Medicine; Modeling; Myocardial; Myocardial dysfunction; Operative Surgical Procedures; Oxygen; Patients; Protocols documentation; Publications; Purpose; Randomized; Role; Sepsis; Septic Shock; Systole; Time; United States; Vasoconstrictor Agents; Ventricular; Work; coronary perfusion; diastolic augmentation; improved

Septic shock is the most common cause of death in medical and surgical intensive care units in the United States. Thirty percent of patients who die from sepsis are noted to have low cardiac output. The purpose of this study is to examine the role of intra-aortic balloon pump counterpulsation (IABC) in the treatment of septic shock. IABC reduces the afterload on the heart, assisted systole, while enhancing its coronary blood flow, diastolic augmentation. We have an ACUC approved protocol to perform a controlled, randomized survival study of IABC in a well characterized low cardiac output animal model of sepsis. The overall effect of the IABC is to increase myocardial oxygen supply by increasing coronary perfusion during diastole, and decrease myocardial oxygen demand by decreasing afterload during systole. We found that intra-aortic balloon pumping resulted in a increase in survival time and a decrease in vasopressor dependence. This data has been analyzed and a manuscript has been accepted for publication in 2008 by Critical Care Medicine.

感染性休克是美国内科和外科重症监护病房最常见的死亡原因。30%死于败血症的病人都有低心输出量。本研究的目的是探讨主动脉内球囊泵反搏（IABC）在感染性休克治疗中的作用。IABC减轻心脏的后负荷，辅助心脏收缩，同时增强其冠状动脉血流量，舒张增强。我们有ACUC批准的方案，在具有良好特征的脓毒症低心排血量动物模型中进行IABC的对照随机生存研究。