Effect Of Intra-aortic Balloon Pump In A Canine Model Of

主动脉内球囊泵在犬模型中的作用

• 批准号: 7332106
• 负责人: Michael A Solomon
• 金额: --
• 依托单位: CLINICAL CENTER
• 依托单位国家: 美国
• 资助国家: 美国
• 起止时间: 至
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/7332106
• 关键词: Effect; Intra; aortic; Balloon; Pump

Septic shock is the most common cause of death in medical and surgical intensive care units in the United States. Thirty percent of patients who die from sepsis are noted to have low cardiac output. The purpose of this study is to examine the role of intra-aortic balloon pump counterpulsation (IABC) in the treatment of septic shock. The goal of placing an intra-aortic balloon pump (IABP) is twofold. It reduces the afterload on the heart, thereby allowing it to do less work, "assisted systole", while enhancing its coronary blood flow, thereby providing it with more energy, "diastolic augmentation." We have an ACUC approved protocol to perform a controlled, randomized survival study of IABC in a well characterized low cardiac output animal model of sepsis. The overall effect of the IABC is to increase myocardial oxygen supply by increasing coronary perfusion during diastole, and decrease myocardial oxygen demand by decreasing afterload during systole. We found that intra-aortic balloon pumping resulted in a increase in survival time and a decrease in vasopressor dependence. This data is continuing to be analyzed and a manuscript is expected to be completed in the next 3-4 months.

在美国，感染性休克是内科和外科重症监护病房中最常见的死亡原因。30%死于败血症的患者心输出量低。本研究的目的是探讨主动脉内球囊反搏（IABC）在治疗感染性休克中的作用。放置主动脉内球囊反搏（IABP）的目的是双重的。它减少了心脏的后负荷，从而使它做更少的工作，“辅助收缩”，同时增强其冠状动脉血流量，从而为它提供更多的能量，“舒张增强”。“我们有一个ACUC批准的方案，在一个特征良好的低心排动物败血症模型中进行IABC的对照、随机生存研究。 IABC的总体作用是通过增加冠脉灌注增加心肌氧供应，并通过减少收缩期后负荷减少心肌氧需求。我们发现，主动脉内球囊反搏导致生存时间延长和血管加压药依赖性降低。这些数据正在继续进行分析，预计在未来3-4个月内完成手稿。